“…The question as to the origin and relationship between the three domains of life is lodged in a phylogenetic impasse. The dominant paradigm is to see the three domains as separated. …”
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“…The immune response in leishmaniasis is very complex and is poorly understood. The Th1 versus Th2 paradigm does not appear to be so clear in visceral leishmaniasis, suggesting that other immunosuppressive or immune-evasion mechanisms contribute to the pathogenesis of VL. …”
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“…Contrary to the current paradigm, RANKL produced by osteoblasts or their progenitors does not contribute to bone remodeling. …”
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“…Here, we review the basics of the intermittent paradigm and highlight methodological issues important for interpreting previous results and designing future experiments. …”
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“…We test this hypothesis with anonymous six-player public goods experiments, an experimental paradigm used to investigate problems related to overusing common resources. …”
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“…The favorable tolerability and toxicity profile alongside the drug’s high genetic barrier to the development of resistance prompted approval of darunavir for HIV-treatment naïve patients. Furthermore, the paradigm of treating HIV with a combination of anti-HIV agents is currently being challenged by ongoing darunavir monotherapy trials and these preliminary data will be discussed.…”
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“…Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. …”
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“…Twenty-five clinically stable schizophrenia patients and 25 age- and gender-matched controls participated in the study. A simple gambling paradigm was used in which five different cues were associated with different reward probabilities (50%, 67%, and 100%). …”
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“…Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. …”
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“…Issues regarding the working of the mind and the guidelines for health and happiness became apparent, and some very interesting generalizations with far-reaching consequences on the general well-being and health have been formulated and put forward for a healthy and happy future for mankind. A paradigm shift is warranted for a closer and better appreciation of neural dynamics at all levels of the brain, namely microscopic, mesoscopic and macroscopic levels!…”
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“…This objective is achieved through coordination of nodes belonging to the same cluster to perform assigned tasks in a cooperative manner avoiding redundant sensing or processing. A paradigm in this concept, a cooperative scheduling scheme for object detection, is presented based on the proposed clustering method.…”
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“…This allows us to make their link with responsibility explicit and to determine if a shift in the connection between risk and responsibility can be outlined. (1) In the engineer’s paradigm, the quantitative conception of risk does not include any concept of responsibility. …”
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“…To do so requires a paradigm shift—moving from a focus on individual treatment to a prevention approach that engages the entire family as the unit of care. …”
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“…In this study, the feasibility of fMRI in the amygdalae at 7 Tesla was investigated. A paradigm based on the presentation of fearful faces was used for stimulation. …”
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“…In this paper we show that choroid plexus cells can be cultured on silicon chips and that sensors register in real time changes in their activity, constituting an interesting experimental paradigm for cell biology and medical research. To validate the signals recorded (metabolism = peri-cellular acidification, oxygen consumption = respiration; impedance = adhesion, cell shape and motility) we performed experiments with compounds that act in a well-known way on cells, influencing these parameters. …”
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“…Current trends in implantology have weakened the conservative paradigm, and practitioner's objectivity has been inclined more toward providing the tooth substitutes often flaunted as equal or even superior to conservation of natural tooth…”
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“…Visual temporal event-structure coding was tested in 17 high-functioning adolescents and adults with autism spectrum disorder (ASD) and mental- and chronological-age matched typically-developing (TD) individuals using a perceptual simultaneity paradigm. Visual simultaneity thresholds were lower in individuals with ASD compared to TD individuals, suggesting that autism may be characterised by increased parsing of temporal event-structure, with a decreased capability for integration over time. …”
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“…Previous studies have found that attention orienting is influenced by the orienting processes of previous trials in a spatial cueing paradigm. This study mainly investigated whether this sequence effect could happen for a non-predictive arrow cue and whether it was influenced by the cue-target SOAs in previous and current trials. …”
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“…This study aims to understand mechanisms leading to the initiation of type IV secretion using conjugative plasmid paradigm R1. We analyze the general requirements for plasmid encoded conjugation proteins and DNA sequence within the origin of transfer (oriT) for protein secretion activity using a Cre recombinase reporter system. …”
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“…This effect was not moderated by goal-relevance, suggesting that our paradigm tapped into the perceptual quality of representations rather than, for example, their linguistic availability. …”
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