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9141“…Using type IV pili as a paradigm, we will highlight in this review common aspects and key biological differences of this group of filamentous structures.…”
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9142“…Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. …”
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9143“…Advances in imaging technology, especially in the last two decades, have led to a paradigm shift in the field of image-guided interventions in urology. …”
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9144“…The ramification of a diagnosis of oligometastasis is a change in treatment paradigm, i.e. if the primary cancer site (if still present) is controlled, or resected, and the metastatic sites are ablated (surgically or with radiation), a prolonged disease-free interval, and perhaps even cure, may be achieved. …”
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9145“…However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to ‘cough hypersensitivity syndrome’ suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. …”
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9146“…Here we faithfully adapt a well-established animal paradigm used for affective processing, conditioned place preference (CPP) for use in typically developing children between the ages of 30–55 months. …”
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9147“…Our approach proposes a paradigm shift in the physics of complex networks, toward the use of power-law deviations to infer meso-scale structure from macroscopic observations.…”
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9148por Habchi, Ouazna, Rey, Elodie, Mathieu, Romain, Urquizar, Christian, Farnè, Alessandro, Pélisson, Denis“…Here, we demonstrate that deployment of human covert attention, measured in stationary eye conditions, can be boosted across space by changing the size of ocular saccades to a single position via a specific adaptation paradigm. These findings indicate that spatial attention is more widely affected by oculomotor plasticity than previously thought.…”
Publicado 2015
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9149“…This approach utilizes expected utility paradigm and is applied to a benchmark decision problem in the field of economics.…”
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9150“…A major additional benefit of the Bayesian paradigm is that we obtain rigorous and useful credible intervals of the evolving spectral structure. …”
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9151“…In this study, we present a paradigm that can be used to study repeated simulations of the emotional future in a manner that overcomes phenomenological confounds between positive and negative events. …”
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9152“…The introduction of transcatheter aortic valve replacement (TAVR in US - TAVI in Europe) has resulted in a paradigm shift in the treatment of patients with severe aortic stenosis. …”
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9153“…In this study, a duration summation paradigm was used to examine whether summation of temporal durations introduces an underestimation or overestimation bias, and whether this bias is common to visual and auditory modalities. …”
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9154por Huang, Qiang, Zhou, Changhua, Chen, Xiao, Dong, Bing, Chen, Siqi, Zhang, Ning, Liu, Yawei, Li, Anrong, Yao, Meicun, Miao, Ji, Li, Qing, Wang, Zhong“…This prodrug strategy may constitute a novel paradigm to improve the therapeutic index of Sunitinib and other TKI or anti-angiogenesis drugs in general.…”
Publicado 2015
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9155“…In the contemporary era, use of drugs is the dominant paradigm of health care. The most quotidian drug used for fever and pain is paracetamol. …”
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9156por Obst, Reinhard“…The proliferation of specific lymphocytes is the central tenet of the clonal selection paradigm. Antigen recognition by T cells triggers a series of events that produces expanded clones of differentiated effector cells. …”
Publicado 2015
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9157“…Together these observations now challenge the traditional paradigm of preponderate clonal evolution in T. cruzi and highlight the need for additional, intensive and appropriately sampled field surveys, complemented by high resolution, combined nuclear and mitochondrial population genetics analyses.…”
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9158por Appel, Eric A., Tibbitt, Mark W., Webber, Matthew J., Mattix, Bradley A., Veiseh, Omid, Langer, Robert“…Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employing rationally engineered polymer-nanoparticle interactions. …”
Publicado 2015
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9159“…Oncology has been revolutionized by the ability to selectively inhibit the growth of cancerous cells while ostensibly avoiding the disruption of proteins and pathways necessary for normal cellular function. This paradigm has triggered an explosion of targeted therapies for cancer, creating a burgeoning billion-dollar industry of small molecules and monoclonal antibodies [1]. …”
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9160por van der Stel, Jaap“…This second part focuses on the question of how addiction care can deal with the consequences of the emerging paradigm of personalized or precision medicine, which is based on the fundamental assumption that individual differences matter. …”
Publicado 2015
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