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9201“…Novel immunotherapy drugs such as checkpoint inhibitors have been paradigm changing in melanoma, non-small cell lung cancer and urothelial cancers. …”
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9202por Babu, M. Madan“…This work laid the foundation for the sequence–structure–function paradigm, which states that the sequence of a protein determines its structure, and structure determines function. …”
Publicado 2016
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9203por Katsanis, Nicholas“…Studies of human genetic disorders have traditionally followed a reductionist paradigm. Traits are defined as Mendelian or complex based on family pedigree and population data, whereas alleles are deemed rare, common, benign, or deleterious based on their population frequencies. …”
Publicado 2016
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9204por Duennwald, Martin L“…Using Huntington's disease as a paradigm, I review here the central role of both the HSR and the UPR in defining the toxicity associated with polyQHtt in Huntington's disease. …”
Publicado 2015
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9205por Sieg, Emily P, Stepanyan, Hayk, Payne, Russell, Frauenhoffer, Elizabeth, Specht, Charles S, Langan, Sara, Rizk, Elias“…We go on to discuss the clinical presentation, radiographic characteristics, and management paradigm for these rare lesions. Our patient presented with acute confusion, inability to balance a checkbook, and gait imbalance. …”
Publicado 2016
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9206“…Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm for a ubiquitously expressed transcription factor and is involved in regulating the expression of genes associated with a wide range of cellular processes in mammalian cells. …”
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9207“…As observed for proteins, the function of the RNA is tightly regulated by its structure, and a common paradigm has been that genome function is temporally modulated by structural changes in the 5′-leader. …”
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9208“…The secretory pathway remains a central paradigm of modern cell biology. Its elucidation 50 years ago inspired tremendous multidisciplinary and on-going efforts to understand the machinery that makes it run, the adaptations that permit it to serve the needs of specialized cell types, and the pathological consequences that arise when it is perturbed.…”
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9209“…Traditionally tumors were classified based on anatomic location but now specific genetic mutations in cancers are leading to treatment of tumors with molecular targeted therapies. This has led to a paradigm shift in the classification and treatment of cancer. …”
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9210“…We review basic properties of these horizons and summarize applications to mathematical physics, numerical relativity, and quantum gravity. This paradigm has led to significant generalizations of several results in black hole physics. …”
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9211“…Another contribution is that a new paradigm is introduced that bears closer resemblance to real life public good dilemmas than previous research paradigms do.…”
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9212por de Greef, R, Elassaiss‐Schaap, J, Chatterjee, M, Turner, DC, Ahamadi, M, Forman, M, Cutler, D, de Alwis, DP, Kondic, A, Stone, J“…Contrary to the established classical chemotherapy‐dosing paradigm, a maximum tolerated dose approach does not always produce better clinical outcomes for novel targeted therapies, as their efficacy is frequently robust at pharmacologically active doses below the maximum tolerated dose. …”
Publicado 2016
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9213“…A sensor architecture using the Compressive Sensing (CS) paradigm is compared to a standard compression scheme using wavelets in terms of energy consumption vs. reconstruction quality, and, more importantly, vs. performance of fetal heart beat detection in the reconstructed signals. …”
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9214por Zheng, Jimiao, Gao, Ming, Huynh, Nhan, Tindell, Samuel J., Vo, Hieu D. L., McDonald, W. Hayes, Arkov, Alexey L.“…Here, we use an evolutionarily conserved germline organelle, the germ granule, as a paradigm. In Drosophila embryos, we map one of its interactomes using a novel in vivo crosslinking approach that employs two interacting granule proteins and determines their common neighbor molecules. …”
Publicado 2016
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9215por Rieznik, Andrés, Moscovich, Lorena, Frieiro, Alan, Figini, Julieta, Catalano, Rodrigo, Garrido, Juan Manuel, Álvarez Heduan, Facundo, Sigman, Mariano, Gonzalez, Pablo A.“…We implemented a Choice Blindness Paradigm containing political statements in Argentina to reveal the existence of categorical ranges of introspective reports, identified by confidence and agreement levels, separating easy from very hard to manipulate decisions. …”
Publicado 2017
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9216“…As the driving force is in fact the ventilator, the phraseology should preferably be changed to ventilator induced pneumonia to convey the in depth meaning of the term thus evading the terminology currently in practice. A new and emerging paradigm dealing with all side effects of mechanical ventilation can be helpful to solve this etymological conflict.…”
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9217por Melosky, Barbara“…The treatment paradigm for metastatic non-small cell, non-squamous lung cancer is continuously evolving due to new treatment options and our increasing knowledge of molecular signal pathways. …”
Publicado 2017
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9218“…Progress towards such a significant development in the field of sport and exercise genomics will require a paradigm shift in line with recent recommendations for international collaborations such as the Athlome Project (see www.athlomeconsortium.org). …”
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9219por Barrett, Lisa Feldman“…The last two decades of neuroscience research have brought us to the brink of a paradigm shift in understanding the workings of the brain, however, setting the stage to revolutionize our understanding of what emotions are and how they work. …”
Publicado 2017
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9220“…Two experiments aimed at investigating how working memory capacity (WMC) related to processing wh-extractions in both a grammatical judgment and a translation task by using the Operation Span task. A self-paced paradigm was used to collect response times and accuracy rates. …”
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