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  1. 9241
    por Jia, Lin, Jiang, Shu-Man, Liu, Jing
    Publicado 2017
    “…Moreover, the concept of whole-course intervention with a focus on disease prevention and a new model of integrated therapy based on alterations of lifestyle and psychology are being gradually established. This paradigm may substantively impact the prevention and treatment of digestive diseases.…”
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    Behavioral gastroenterology: An emerging system and new frontier of action
  2. 9242
    “…With this review, we provide an overview of topics currently in controversy or debate, and we identify paradigm shifts in the understanding, management, and prevention of ACL tears.…”
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    Management of Anterior Cruciate Ligament Injury: What's In and What's Out?
  3. 9243
    “…One such locus is the budding yeast centromere, which is a paradigm for targeted cohesin loading. The kinetochore, a multiprotein complex that connects centromeres to microtubules, drives the recruitment of high levels of cohesin to link sister chromatids together. …”
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    The Kinetochore Receptor for the Cohesin Loading Complex
  4. 9244
    por Rabinowits, Guilherme
    Publicado 2017
    “…Here, we review the evidence and controversies around chemotherapy in MCC as well as two recent studies on immunotherapy that changed the treatment paradigm for this disease.…”
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    Is this the end of cytotoxic chemotherapy in Merkel cell carcinoma?
  5. 9245
    “…The aim of the present study was to verify the existence of subgroups of patients after LH stroke by searching for dissociations between performance on the lexical decision task based on the semantic priming paradigm and performance on direct memory, semantic association and language tasks. …”
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    Heterogeneity in semantic priming effect with a lexical decision task in patients after left hemisphere stroke
  6. 9246
    por Kirschfeld, Kuno
    Publicado 2017
    “…In neuroscience, an approach to the problem via the visual system has produced a paradigm using perceptual suppression, changing with time. …”
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    How we perceive our own retina
  7. 9247
    “…This study provides a new paradigm of biomimetic nanotechnology for biomedical applications.…”
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    Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment
  8. 9248
    “…In this work, a within-subjects experiment is conducted using a flicker paradigm, with which the hit rate and response time for change detection are obtained. …”
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    Change detection in pictorial and solid scenes: The role of depth of field
  9. 9249
    por Abu Bakr, Muhammad, Lee, Sukhan
    Publicado 2017
    “…The paradigm of multisensor data fusion has been evolved from a centralized architecture to a decentralized or distributed architecture along with the advancement in sensor and communication technologies. …”
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    Distributed Multisensor Data Fusion under Unknown Correlation and Data Inconsistency
  10. 9250
    “…Herein, we presented the history of One Health, reviewed current public health threats, and suggested opportunities for the field of public health through better understanding of the One Health paradigm.…”
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    One Health Perspectives on Emerging Public Health Threats
  11. 9251
    “…To explore the evolutionary prerequisites of such deictic ability, the present study investigates the ability of chimpanzees to adjust their communicative signals to the distance of a referent. A food-request paradigm in which the chimpanzees had to request a close or distant piece of food on a table in the presence/absence of an experimenter was employed. …”
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    The higher the farther: distance-specific referential gestures in chimpanzees (Pan troglodytes)
  12. 9252
    por Vorontsov, D. D., Dyakonova, V. E.
    Publicado 2017
    “…We have recently demonstrated that preceding motor activity can facilitate decision-making not only in humans and mammals but also in molluscs.(5) In the behavioral paradigm used, snails Lymnaea stagnalis were removed from their natural environment (water) and placed in a dry, asymmetrically lit arena from which they had to decide which way to go in order to reach an aquatic environment. …”
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    Light-dark decision making in snails: Do preceding light conditions matter?
  13. 9253
    por Campos, Samuel K.
    Publicado 2017
    “…Since 2012, our understanding of human papillomavirus (HPV) subcellular trafficking has undergone a drastic paradigm shift. Work from multiple laboratories has revealed that HPV has evolved a unique means to deliver its viral genome (vDNA) to the cell nucleus, relying on myriad host cell proteins and processes. …”
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    Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2
  14. 9254
    “…Regenerative endodontic procedures (REPs) have been described as a “paradigm shift” in the treatment of immature teeth with pulp necrosis and underdeveloped roots, as there is the potential for further root maturation and return of vitality. …”
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    Alkaline Materials and Regenerative Endodontics: A Review
  15. 9255
    “…Recently, stem-like cells have been isolated from pituitary neoplasms raising the possibility that a cytological hierarchy exists, in keeping with the cancer stem cell paradigm. In this manuscript, we review the evidence for the existence of pituitary stem cells, their role in maintaining organ homeostasis and the regulation of their differentiation. …”
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    Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis
  16. 9256
    por Capodanno, Davide
    Publicado 2017
    “…Bioresorbable scaffolds (BRS) represent a novel paradigm in the 40-year history of interventional cardiology. …”
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    Bioresorbable Scaffolds in Coronary Intervention: Unmet Needs and Evolution
  17. 9257
    por Müller, Manuel M.
    Publicado 2017
    “…Traditionally, PTMs have been considered as reversible attachments to nucleophilic functional groups on amino acid side chains, whereas the polypeptide backbone is often thought to be inert. This paradigm is shifting as chemically and functionally diverse alterations of the protein backbone are discovered. …”
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    Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges
  18. 9258
    por Omodei, Elisa, Arenas, Alex
    Publicado 2018
    “…Energy grids are facing a relatively new paradigm consisting in the formation of local distributed energy sources and loads that can operate in parallel independently from the main power grid (usually called microgrids). …”
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    A network approach to decentralized coordination of energy production-consumption grids
  19. 9259
    “…Specification of the three germ layers by graded Nodal signaling has long been seen as a paradigm for patterning through a single morphogen gradient. …”
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    Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages
  20. 9260
    “…In the recent times, there has been a shift of paradigm from a hypo- to hyper-responsive/primed model of neutrophil dysfunction in periodontal etiopathogenesis. …”
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    Neutrophil priming: Implications in periodontal disease
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