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  1. 9461
    “…Genetic changes are difficult to reverse; thus, epigenetic aberrations, including changes in DNA methylation, histone modifications, and noncoding RNAs, with potential reversibility, have attracted attention as pharmaceutical targets. The current paradigm is that histone deacetylases (HDACs) regulate gene expression via deacetylation of histone and nonhistone proteins or by forming corepressor complexes with transcription factors. …”
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    Preclinical and clinical progress for HDAC as a putative target for epigenetic remodeling and functionality of immune cells
  2. 9462
    por Boyle, Deborah A.
    Publicado 2021
    “…Furthermore, multiple psychosocial sequelae characterize the patient and family coping paradigm. Heightened education about the pathophysiology of cancer cachexia and awareness of intra-familial emotional distress can enhance oncology nurses' advocacy about, and attentiveness to, this common manifestation of advanced cancer.…”
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    Contemporary Insights into Cancer Cachexia for Oncology Nurses
  3. 9463
    “…As the complexity and size of bioimage data continues to grow, this new analysis paradigm is becoming increasingly ubiquitous. In this Review, we begin by introducing the concepts needed for beginners to understand deep learning. …”
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    Deep learning for bioimage analysis in developmental biology
  4. 9464
    “…Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblastoma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. …”
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    Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma
  5. 9465
    “…While investigating peroxynitrite-dependent oxidation in murine RAW 264.7 macrophage cells, we observed that removal of the Labile Iron Pool (LIP) by chelation increases the intracellular oxidation of the fluorescent indicator H(2)DCF, so we concluded that the LIP reacts with peroxynitrite and decreases the yield of peroxynitrite-derived oxidants. This was a paradigm-shifting finding in LIP biochemistry and raised many questions. …”
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    The Labile Iron Pool Reacts Rapidly and Catalytically with Peroxynitrite
  6. 9466
    “…Only a few cases of COVID-19 associated with PCD are reported in the literature, despite thromboembolism being the common paradigm between the two diseases. We present the case of a 64-year-old adult with acute severe COVID-19 pneumonia who developed PCD despite constantly elevated activated partial thromboplastin time and international normalized ratio. …”
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    Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19
  7. 9467
    “…Our notions of protein function have long been determined by the protein structure–function paradigm. However, the idea that protein function is dictated by a prerequisite complementarity of shapes at the binding interface is becoming increasingly challenged. …”
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    Intrinsically disordered proteins: modes of binding with emphasis on disordered domains
  8. 9468
    “…Recently, on-surface synthesis has emerged as a disruptive paradigm to design previously precluded compounds and nanomaterials. …”
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    On-surface synthesis of organocopper metallacycles through activation of inner diacetylene moieties
  9. 9469
    “…We survey the last decade of experimentation and research in the field of mobile CrowdSensing, a paradigm centred on users’ devices as the primary source for collecting data from urban areas. …”
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    How Mobility and Sociality Reshape the Context: A Decade of Experience in Mobile CrowdSensing
  10. 9470
    “…According to the “Developmental Origins of Health and Disease” paradigm, environmental exposures (in utero and early life) can permanently alter the body’s structure, physiology, and metabolism, increasing illness risk and/or speeding up disease progression in offspring, adults, and even generations. …”
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    Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders
  11. 9471
    “…Here, we discuss the opposing activities of immune cells populating the tumor microenvironment in both cancer progression and anti-cancer responses, with a focus on cytotoxic T cells and on the molecular mechanisms responsible for the efficient suppression of their killing activities as a paradigm of the power of cancer cells to shape the microenvironment for their own survival and expansion.…”
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    Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment
  12. 9472
    Publicado 2021
    “…To smooth this challenge, IoT emerges as an encouraging paradigm because it provides the scalability required for this purpose, supporting continuous and reliable health monitoring on a global scale. …”
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    An IoT-Based Healthcare Platform for Patients in ICU Beds During the COVID-19 Outbreak
  13. 9473
    “…Based on this psychophysical paradigm, we used electroencephalography and eye-tracking recordings to investigate the neural correlates related to the conscious perception of intra-saccadic motion. …”
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    Neural correlates of intra-saccadic motion perception
  14. 9474
    “…Thus, PPGLs serve as an ideal paradigm for developing, testing and implementing precision medicine concepts in the clinic. …”
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    Precision Medicine in Phaeochromocytoma and Paraganglioma
  15. 9475
    “…This review discusses the role of pseudophosphatases in MAPK signaling, highlighting the function of phosphoserine/threonine/tyrosine-interacting protein (STYX) and TAK1-binding protein (TAB 1) in regulating MAPKs. Finally, a new paradigm is considered for this well-studied cellular pathway, and signal transduction pathways in general.…”
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    Pseudophosphatases as Regulators of MAPK Signaling
  16. 9476
    por Balestra, Costantino, Kot, Jacek
    Publicado 2021
    “…We must investigate hyperbaric oxygen with a new paradigm of treating oxygen as a potent stimulus of the molecular network of reactions.…”
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    Oxygen: A Stimulus, Not “Only” a Drug
  17. 9477
    “…The treatment paradigm for intracranial aneurysms has evolved with technological advancements, resulting in improved patient outcomes. …”
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    Clipping of Posterior Circulation Intracranial Aneurysms: Maintenance of a Necessary Skill in Low-Resource Settings
  18. 9478
    “…GeoHealth as a research paradigm offers the opportunity to re‐evaluate common research engagement models and science training practices. …”
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    Addressing the Need for Just GeoHealth Engagement: Evolving Models for Actionable Research That Transform Communities
  19. 9479
    por Alwakeel, Ahmed M.
    Publicado 2021
    “…Two different new cloud technologies that inherit some of the traditional cloud computing paradigm are fog computing and edge computing that is aims to simplify some of the complexity of cloud computing and leverage the computing capabilities within the local network in order to preform computation tasks rather than carrying it to the cloud. …”
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    An Overview of Fog Computing and Edge Computing Security and Privacy Issues
  20. 9480
    por Ramadan, Qasem, Zourob, Mohammed
    Publicado 2021
    “…3D printing technology has emerged as a key driver behind an ongoing paradigm shift in the production process of various industrial domains. …”
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    3D Bioprinting at the Frontier of Regenerative Medicine, Pharmaceutical, and Food Industries
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