“…Here we propose a new model that diverges from the textbook enhancer–promoter looping paradigm and offer a synthesis of the literature to make a case for its plausibility, focusing on the coactivator p300.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Besides physiopathological contribution of adipose-derived molecules, a new paradigm is emerging following the discovery that adipocytes have a propensity to extrude damaged mitochondria in the extracellular space, to be conveyed through the blood and taken up by cell acceptors, in a process called intercellular mitochondria transfer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The notion of Corporate Environmental Responsibility has been extensively researched in the literature so far, but less is known about how this concept fits into the circular economy paradigm. We performed a moderated mediation analysis in order to identify the mechanism that links corporate environmental responsibility with readiness for change towards a circular economy business model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nevertheless, tumors can greatly rely on autophagy as an alternative source for metabolites, and which desensitizes cancer cells to therapeutic stress, hindering the success of any current treatment paradigm. Autophagy is a conserved process by which cells turn over their own constituents to maintain cellular homeostasis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The importance of a newly designed curriculum to impart broader knowledge to future radiation oncologists is emphasized in this report. A paradigm shift in the approach to the traditional radiation biology course is required to train residents for the future of oncology.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Convergent crises have amplified a growing chorus of voices and movements calling for new thinking and new practices to adapt to these shifts, mitigate their impact, and address their root causes through far reaching changes in social and economic life and values, including breaking with the free market paradigm. In the face of a historic choice between transition or multiple systems collapse that deepen injustice and threaten planetary survival, I make the case for expanding on liberatory tendencies in Extension programs to build capacities for response-ability to transition toward more just and sustainable futures.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: Once the paradigm of intelligence as the only predictor of academic performance has been overcome, the influence of other variables, such as reasoning, verbal fluency, executive functions, motivation and self-esteem, was studied. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The patient underwent a complex tumor resection without complications using an exhaustive multi-modal neuromonitoring paradigm throughout the dissection and resection of the tumor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Connection is made considering chlorophyll-a as a paradigm for molecular spectroscopy, 22 iconic materials as paradigms for 3D materials spectroscopy, and the V(N)(−) defect in hexagonal boron nitride as an example of the spectroscopy of defects in 2D materials pertaining to nanophotonics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The gastrointestinal endoscopy paradigm is rapidly changing, and technological advancements are largely responsible. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Most of these treatments are delivered in fractions of equal doses of radiation (Fractional Equivalent Dosing (FED)) in days to weeks. This treatment paradigm has remained unchanged in the past century and does not account for the development of radioresistance during treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An alternative approach to uncomplicated UTI is warranted as the current paradigm fails to take urobiome dysbiosis into account and contributes to the communal problem of resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The purpose of this review is to present in a novel paradigm what we know about the molecular mechanisms responsible for pain after envenomation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, we analyzed relationships between variants and breakthrough infections, as well as the paradigm of new variants in countries with high vaccination rates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, talker variability did not act as a desirable difficulty in the current paradigm as the few evidenced costs were not related to long-term benefits.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The healthcare industry is undergoing a paradigm shift thanks to Industry 4.0, which provides better user comfort through proactive intervention in early detection and treatment of various diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Target protein degrader is a new paradigm in the small molecule drug discovery field and relates to the term ‘event-driven pharmacology’. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At present, researchers often consider gating and attenuation the same suppression process; however, this assumption is unwarranted because, despite more than 40 years of research, no study has combined them in a single paradigm. We quantified how people perceive self-generated and externally generated touches during movement and rest. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This research shapes a new paradigm considering the human being as a whole, integrating biology and psychology. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso