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2581“…FINDINGS: Changes in drug life cycles have dramatically affected patent medicine markets, which have long been considered a self-evident and self-sustainable source of income for highly profitable drug companies. …”
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2582por Zhao, Xiaoqin, He, Liangmei, Mao, Kaiyun, Chen, Daming, Jiang, Hongbo, Liu, Zhiping“…In addition, the total number of patents in China was much lower than that of the USA. …”
Publicado 2018
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2583por Berghuis, Anne Margreet Sofie, Koffijberg, Hendrik, Terstappen, Leonardus Wendelinus Mathias Marie, Sleijfer, Stefan, IJzerman, Maarten Joost“…Interestingly, the findings show that off-patent generics (such as paclitaxel or doxorubicin), although substantially cheaper than patented drugs, are still relatively costly. …”
Publicado 2018
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2584“…ES waste is utilized for a variety of low-value applications, or alternatively is disposed in landfill with associated economic and environmental burdens. The number of patents pertaining to ES applications has increased dramatically in recent years; of 673 patents granted in the last century, 536 (80%) were published in the last two decades. …”
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2585“…The primary purpose of the patent assessment in this article is to provide loans, or in Indonesia, it is referred to as a patent fiduciary. …”
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2586por England, Ross N, Drapeau, Elizabeth, Hosseinzadeh, Reihaneh, Weissman, Drew, Hensley, Scott“…DISCLOSURES: Reihaneh Hosseinzadeh, MASc, Acuitas Therapeutics: Employee Drew Weissman, MD, PhD, Intellectual Property/Patents: D.W. is named on the first patent describing nucleoside-modified mRNA and on patents describing its use as a treatment and vaccine platform. …”
Publicado 2023
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2587“…The ‘D’ part in R&D is represented by the top 10% most highly cited ‘excellent’ patents worldwide. The ‘R’ part is captured by research articles in international scholarly journals that are cited by these patented technologies. …”
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2588por Gallo, Valentina, Alessi, Eva, Montilla, Simona, Altamura, Gianluca, Traversa, Giuseppe, Trotta, Francesco“…In terms of estimated timing for the conclusion of each stage of the P&R negotiation process, the difference between Off-patent and In-patent pharmaceutical procedures was statistically significant by the Log-Rank test. …”
Publicado 2022
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2589por Lozinsky, Vladimir I.“…However, in spite of considerable attention to these materials and intensive elaboration of their new examples, as well as the impressive growth in the number of the publications and patents on this topic over the past two decades, a marked variability of the used terminology and definitions is frequently met with in the papers, reviews, theses, patents, conference presentations, advertising materials and so forth. …”
Publicado 2018
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2590por Chia, C. S. Brian“…FDA granted Emergency Use Authorization for the oral viral main protease inhibitor, Nirmatrelvir, to treat patients with mild-to-moderate COVID-19. This patent review reveals the structure–activity relationship of key inhibitors described in the patent WO 2021/250648 A1.…”
Publicado 2022
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2591“…Subsequent angiogram showed a widely patent RPA and MBTS. An echocardiogram at 1-month post-thrombectomy showed a widely patent MBTS with continuous flow seen entering both branch pulmonary arteries. …”
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2592“…The fistulas were isolated by implanting patent ductus arteriosus occluders in the renal artery stumps. …”
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2593“…Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. …”
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2594Promote Green Innovation in Manufacturing Enterprises in the Aspect of Government Subsidies in China“…The moderating effect of public participatory environmental regulation on government subsidies is different on different green patents, with a more negative effect on green invention patents than on green utility model patents. …”
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2595por Raja Mamat, Tengku A., Sayuti, Khairil A., Nadarajan, Chandran, Mohd Zain, Mohd R.“…Further imaging confirmed right pulmonary hypoplasia, associated with a patent foramen ovale, patent ductus arteriosus and vertebral anomalies. …”
Publicado 2021
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2596por Bhalala, Utpal S., Hemani, Malvi, Shah, Meehir, Kim, Barbara, Gu, Brian, Cruz, Angelo, Arunachalam, Priya, Tian, Elli, Yu, Christine, Punnoose, Joshua, Chen, Steven, Petrillo, Christopher, Brown, Alisa, Munoz, Karina, Kitchen, Grant, Lam, Taylor, Bosemani, Thangamadhan, Huisman, Thierry A. G. M., Allen, Robert H., Acharya, Soumyadipta“…The logistic regression analysis showed that the proportion of patent airways progressively increased with an increasing head-tilt angle, with > 95% probability of a patent airway at head-tilt angle 144–150°.…”
Publicado 2016
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2597por de Picciotto, Carole, Duménil, Coraline, Auzel, Olivier, Giraud, Violaine, Bonay, Marcel“…However, mechanical ventilation with a positive end-expiratory pressure can induce or worsen a right-to-left shunt through a patent foramen ovale associated with systemic hypoxemia. …”
Publicado 2017
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2598“…The patient had associated deep venous thrombosis of the lower limb with multiple pulmonary emboli and patent foramen ovale. This case report emphasizes the under-recognition of intense endurance exercise as a risk factor for venous thromboembolism and highlights the potentially debilitating embolic sequelae of venous thromboembolism in patients with patent foramen ovale.…”
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2599“…An active thrombus through an undiagnosed patent foramen ovale was found requiring emergent surgical intervention with a positive outcome. …”
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2600por Tenni, Brigitte, Moir, Hazel V. J., Townsend, Belinda, Kilic, Burcu, Farrell, Anne-Maree, Keegel, Tessa, Gleeson, Deborah“…They were: trade agreements (divided into EU FTAs and those that include the USA); use of TRIPS flexibilities (divided into compulsory licencing and parallel importation); patent expiry/generic entry/generic pathway (divided into comparative studies and single country studies); patent policies (also divided into comparative studies and single country studies) and TRIPS-plus rules (divided into data exclusivity, patent term extensions and secondary patenting). …”
Publicado 2022
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