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  1. 4021
    por Roussel, Y., Raoult, D.
    Publicado 2020
    “…Some are protected by patents, such as remdesivir, others0020stare not, such as hydroxychloroquine. …”
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    Influence of conflicts of interest on public positions in the COVID-19 era, the case of Gilead Sciences
  2. 4022
    “…Importantly, lack of patentability of the drug substance also limits the likelihood of an expensive, full development programme in anything other than orphan indications. …”
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    Towards Better Delivery of Cannabidiol (CBD)
  3. 4023
    “…The samples of two morphologically-different taxa P. uralensis and P. patents s.str. were shown to form a single clade on the phylogenetic tree. …”
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    Phylogenetic relationships and status of taxa of Pulsatilla uralensis and P. patens s.str. (Ranunculaceae) in north-eastern European Russia
  4. 4024
    “…We are presenting a three and half years old child with a delayed/missed diagnosis of large patent ductus arteries (PDA) who present with significant PAH. …”
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    Pulmonary hypertension associated with congenital heart disease; clinical decision scenario
  5. 4025
    por Kim, Soong-Hyun, Bae, Seri, Song, Minsoo
    Publicado 2020
    “…In this regard, we present a concise analysis of the recent development of ARS inhibitors based on small molecules from the discovery research stage to clinical studies as well as a recent patent analysis from the medicinal chemistry point of view.…”
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    Recent Development of Aminoacyl-tRNA Synthetase Inhibitors for Human Diseases: A Future Perspective
  6. 4026
    “…Complete vitrectomy with a patent tunnel from posterior chamber to anterior chamber (iridectomy-zonulectomy) is the effective procedure to manage of malignant-like glaucoma.…”
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    A refractory malignant glaucoma posttrabeculectomy in vitrectomized eye: A case report and review of the literature
  7. 4027
    “…We resent this case for discussion of which surgical strategy/options are available in order to treat the mitral valve and avoid injuring the patent graft.…”
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    Redo mitral valve replacement through minithoracotomy on ventricular fibrillation: Bailout for a nightmare Redo
  8. 4028
    “…This article highlights the research findings and patent developments in the last 2 years especially, in EO antiviral activity, antiviral drug delivery, vaccine delivery, viral resistance development, and repurposing EO compounds against SARS-CoV-2.…”
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    Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects
  9. 4029
    “…Postoperative computed tomography angiography revealed that the graft was patent. At 7 months postoperatively, the patient weighed 8.5 kg, and echocardiography revealed good ventricular function. …”
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    Coronary Artery Bypass Grafting in an Infant after an Arterial Switch Operation
  10. 4030
    “…Adalimumab, as a TNF inhibitor biologic for the treatment of rheumatoid arthritis, is one of the top-selling drugs worldwide. As its various patents have gradually expired, experiments on its biosimilars are constantly being implemented. …”
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    Efficacy and Safety of Adalimumab Biosimilars: Current Critical Clinical Data in Rheumatoid Arthritis
  11. 4031
    “…Choices of blue food colourants are extremely limited, with only two options in the USA, synthetic blue no. 1 and no. 2, and a third available in Europe, patent blue V. The food industry is investing heavily in finding naturally derived replacements, with limited success to date. …”
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    Natural Blues: Structure Meets Function in Anthocyanins
  12. 4032
    por Gabryelska, Marta
    Publicado 2021
    “…Going through my recent “scientific awakening,” I fully acknowledged the rules of the game: to write, to publish, to patent, to apply for grants and awards, and finally, to engage in all forms of coscientific endeavors. …”
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    Science: priceless, but costly
  13. 4033
    “…In recent years, many Btk inhibitors have been patented and reported in the literature. In this review, we summarized the (ir)reversible Btk inhibitors recently developed and studied clinical trials and preclinical investigations for malignancies, chronic inflammation conditions and SARS-CoV-2 infection, covering advances in the field of medicinal chemistry. …”
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    Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective
  14. 4034
    “…New data are still emerging despite drugs already going off patent. This review aims to provide readers with the most current knowledge on the pharmacokinetics of the triazoles: fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. …”
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    Clinical Pharmacokinetics of Triazoles in Pediatric Patients
  15. 4035
    “…The transcatheter closure of patent ductus arteriosus (TCPC) has been demonstrated to be feasible even in infants weighing ≤1000 g. …”
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    Feasibility and Safety of Percutaneous Cardiac Interventions for Congenital and Acquired Heart Defects in Infants ≤1000 g
  16. 4036
    “…Cleidocranial dysplasia (CCD; OMIM 119600) is a rare autosomal dominant skeletal dysplasia, which is mainly characterized by persistently open or delayed closure of fontanelle, patent skull sutures, abnormal clavicles, pectus excavatum, short stature, supernumerary teeth, and sinus and middle ear infections. …”
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    Cleidocranial Dysplasia Causing Respiratory Distress in Neonates: A Case Report and Literature Review
  17. 4037
    “…This review presents an updated summary of the activities of different seaweed compounds and fractions based on scientific and patent literature.…”
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    Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics
  18. 4038
    “…His medical history included infantile left hemiparesis and operation of patent ductus arteriosus. Emergency surgery was scheduled due to the extremely dilated stomach and gastric pneumatosis, and a total gastrectomy was performed. …”
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    Fatal Outcome of Emphysematous Gastritis due to Sarcina ventriculi Infection
  19. 4039
    “…Patent foramen ovale (PFO) in patients with carcinoid heart disease (CHD) may result in hypoxia due to the presence of large right (R) to left (L) intracardiac shunts leading to hypoxia and worsening clinical condition. …”
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    Relentless Hypoxia in a Patient With Carcinoid Syndrome
  20. 4040
    “…At 6 months review, the stents remained widely patent and the patient was symptom-free.…”
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    Y Stent Rendezvous to Treat Symptomatic Innominate Artery Stenosis
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