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  1. 4561
    “…A plethora of protein nanoparticles applications via different routes of administration are explored and reported by eminent researchers which are highlighted in the present review along with the patents granted for protein nanoparticles as drug delivery carriers.…”
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    Protein Based Nanostructures for Drug Delivery
  2. 4562
    “…Based on these results, a technology named Somartex(®) for “Self Operating MARine Trapping Extractor” was patented and built to transfer the concept from closed aquarium systems to open marine ecosystems.…”
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    Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems
  3. 4563
    “…Our patient's hypoxemia improved with inhaled nitric oxide as an adjunct to mechanical ventilation without requiring extracorporeal membrane oxygenation, and eventually a percutaneous closure with a 30 mm CardioSeal patent foramen ovale closure device was accomplished. …”
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    Inhaled nitric oxide mitigates need for extracorporeal membrane oxygenation in a patient with refractory acute hypoxemic respiratory failure due to cardiac and pulmonary shunts
  4. 4564
    “…However, this pathway is not always patent due to the extensive stenosis or occlusion of the origin of CA. …”
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    Pancreaticoduodenal arcades as salvage route for transarterial embolization of life-threatening hepatic hemorrhage in patients with severe celiac axis stenosis: Case series
  5. 4565
    “…Research teams and companies are currently in dispute over patents for these CRISPR-Cas systems as numerous powerful applications are concurrently under development. …”
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    CRISPR-Cas systems: ushering in the new genome editing era
  6. 4566
    “…This is because a fixed reference point is unattainable due to ground vibrations during train passage. In this paper, a patented signal processing technique for evaluation of pseudo-deflection is presented to recover dynamic deflection of a railroad sleeper using a coupled measurement of acceleration and strain at the concrete sleeper. …”
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    Dynamic Deflection of a Railroad Sleeper from the Coupled Measurements of Acceleration and Strain
  7. 4567
    “…Patient 2 had VCD and a patent ductus arteriosis who necessitated surgical closure. …”
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    Co-existence of vocal cord dysfunction with pulmonary conditions other than asthma: A case series
  8. 4568
    “…Results also shows an increase in the relative share of industries in applied research, as measured through patents. Such divergence in university and industry research activities may hinder industries’ ability to translate basic knowledge into technological innovation, and could lead to a growing misalignment between doctoral training and future job expectations. …”
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    Vanishing industries and the rising monopoly of universities in published research
  9. 4569
    por Niosi, Jorge, McKelvey, Maureen
    Publicado 2018
    “…These cascades involve a long series of interlinked radical innovations, which can be traced through various scientific and technological indicators like patents and publications. Innovation cascades are relevant to industry, because they make the future less predictable. …”
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    Relating business model innovations and innovation cascades: the case of biotechnology
  10. 4570
    “…On admission, magnetic resonance imaging and angiography demonstrated patent bypass, but severe stenosis of left ICA with no opacification of the left AChA and A1 portion of the left ACA. …”
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    Hemodynamic ischemia of the anterior choroidal artery and reversal by carotid artery stenting 10 years after ipsilateral superficial temporal artery-middle cerebral artery bypass for symptomatic left middle cerebral artery stenosis
  11. 4571
    “…She recovered just two days after the injection, but signs of recent cerebral ischemia were seen in Broca’s area on magnetic resonance and transesophageal bubble study echocardiogram revealed a patent foramen ovale. Although rare, we must make great effort to prevent these events instead of treating them.…”
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    Cerebrovascular ischemia following ultrasound-guided foam sclerotherapy
  12. 4572
    “…We carried out a systematic review of >280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.…”
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    Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment
  13. 4573
    “…Owing to the numerous advantages with respect to the commonly used reading techniques, a National Patent was filed in January 2018.…”
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    Real-time dosimetry with radiochromic films
  14. 4574
    “…The PHC was refractory to intravenous and inhaled milrinone and nitroglycerine and intravenous adrenaline, dobutamine, norepinephrine, vasopressin, patent foramen oval (PFO), and CPB support. The management of DOMV and perioperative pulmonary hypertension is discussed.…”
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    Perioperative Management of a Patient with Double Orifice Mitral Valve with Supramitral Ring with Subaortic Membrane with Ventricular Septal Defect and Severe Pulmonary Hypertension: Report of a Rare Case
  15. 4575
    “…MATERIALS AND METHODS: Our technique was applied to all 26 cases: primary omphalocele repair (n = 5), abdominal wall reconstructions after conservative management of large omphaloceles (n = 17), large umbilical hernias (n = 3), and one case of patent vitelointestinal duct with redundant skin. …”
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    Umbilicoplasty in Neonates with a New Technique: Results of 20-Year Follow-Up
  16. 4576
    por Lam, Brian, Roudier, Emilie
    Publicado 2019
    “…These studies have contributed to designate MDM2 as a therapeutic target of choice for cancer treatment and the number of patents for MDM2 antagonists has increased immensely over the last years. …”
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    Considering the Role of Murine Double Minute 2 in the Cardiovascular System?
  17. 4577
    “…While clinical trials are not necessarily required for the development of new drugs or obtaining additional indications in Japan, laws in Europe and the US require clinical trials on children for newly developed drugs; however, pharmaceutical companies are entitled to a 6-mo extension for a patent when pediatric data are added to the attached documents for clinical trials. …”
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    Pediatric drug development in Japan: Current issues and perspectives
  18. 4578
    “…Brevibacillus laterosporus is a globally ubiquitous, spore forming bacterium, strains of which have shown toxic activity against invertebrates and microbes and several have been patented due to their commercial potential. Relatively little is known about this bacterium. …”
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    Phylogenetic determinants of toxin gene distribution in genomes of Brevibacillus laterosporus
  19. 4579
    “…Follow‐up echocardiography identified a patent interatrial communication with bidirectional shunting. …”
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    Graded balloon atrial septostomy for palliation of congenital pulmonary hypertension in a dog: A case report
  20. 4580
    “…Xuebijing (XBJ) injection (a traditional Chinese patent medicine) is a potentially effective drug for AP. …”
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    The efficacy and safety of Xuebijing injection as an adjunctive treatment for acute pancreatitis: Protocol for a systematic review and meta-analysis of randomized controlled trials
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