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  1. 5861
    “…These findings indicate that NCX1 may play a role in maintaining patent DA not only by preventing DA functional closure through reducing cytosolic Ca(2+) level in DASMC but also by delaying the anatomical closure process. …”
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    The Role of Na+/Ca2+ Exchanger 1 in Maintaining Ductus Arteriosus Patency
  2. 5862
    por Ryu, Mikyung, Kim, Juyoung
    Publicado 2017
    “…According to the new policy, off-patent brand-name drugs (original drugs) and generic drugs must be priced the same. …”
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    Perception and attitude of Korean physicians towards generic drugs
  3. 5863
    “…We developed a novel lung-targeted DTX-loaded liposome (DTX-LP), an efficient drug delivery system, with a patented DBaumNC technology to overcome these deficiencies. …”
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    Enhanced antitumor effect on intrapulmonary tumors of docetaxel lung-targeted liposomes in a rabbit model of VX2 orthotopic lung cancer
  4. 5864
    “…This study observed the efficacy and safety of JinqiJiangtang tablets (JQJT tablets, a traditional Chinese patent medicine) for pre-diabetes. Four hundred patients with pre-diabetes at five centres were treated for 12months and followed for an additional 12months to investigate the preventative effects of JQJT tablets (Registration ID: ChiCTR-PRC-09000401). …”
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    JinqiJiangtang tablets for pre-diabetes: A randomized, double-blind and placebo-controlled clinical trial
  5. 5865
    “…METHODS: Out of a series of 173 patients undergoing redo cardiac valve surgery, 24 patients were reoperative via the right anterolateral thoracotomy as the high-risk group on the basis of the proximity of the heart and great vessels to the sternum and the presence and location of patent bypass grafts. RESULTS: In all cases, sternotomy was avoided. …”
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    Right anterolateral thoracotomy: an attractive alternative to repeat sternotomy for high-risk patients undergoing reoperative mitral and tricuspid valve surgery
  6. 5866
    “…The imminent expiry of patents protecting bevacizumab provides other manufacturers with the opportunity to produce highly similar versions known as biosimilars. …”
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    Bevacizumab in Colorectal Cancer: Current Role in Treatment and the Potential of Biosimilars
  7. 5867
    “…Venous hypertension secondary to IVC thrombosis in presence of patent femoral AVG should be considered as a rare cause of prolonged DGF.…”
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    Prolonged Delayed Renal Graft Function Secondary to Venous Hypertension
  8. 5868
    “…In addition, DSCT detected 23 cases with patent ductus arteriosus, 26 systemic-to-pulmonary collaterals, 9 branch pulmonary distortions, and 4 coronary artery anomalies. …”
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    Dual-source Computed Tomography for Evaluating Pulmonary Artery and Aorta in Pediatric Patients with Single Ventricle
  9. 5869
    por Chopra, Rakesh, Lopes, Gilberto
    Publicado 2017
    “…Biosimilars, which have biologic activity comparable to their corresponding reference drugs and are often more cost effective, have the potential to enhance treatment accessibility for patients and provide alternatives for decision makers (ie, prescribers, regulators, payers, policymakers, and drug developers). Impending patent expirations of several oncology biologics have opened up a vista for the development of corresponding biosimilars. …”
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    Improving Access to Cancer Treatments: The Role of Biosimilars
  10. 5870
    “…The urography indicated patent urine excretion and no fistula or stenosis. …”
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    Ureteral reconstruction using a tapered non-vascularized bladder graft: an experimental study in a canine animal model
  11. 5871
    “…Analysis of 77 BCa-bearing patients and 71 controls showed an association between BCa and IR as demonstrated by impaired glucose/insulin homeostasis (increased fasting- and OGTT-induced glucose levels) and deteriorated IR indexes, which was especially patent in premenopausal women. The association between BCa presence and IR was markedly influenced by BMI, being obese BCa patients significantly more insulin resistant than controls. …”
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    Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients
  12. 5872
    “…Notably, AC school-aged children, who comprise ~5% of the population, harbor a third of infections with patent gametocytes between May and August, when transmission transitions from very low to intense. …”
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    Hemoglobin variants shape the distribution of malaria parasites in human populations and their transmission potential
  13. 5873
    “…In total, 36 (90%) children had patent ductus arteriosus, without any gender difference (18 and 18, resp., p=1). …”
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    Treatment and Outcome for Children with Esophageal Atresia from a Gender Perspective
  14. 5874
    “…After 1 month, stents were patent in all patients (n = 73). Stent obstruction was noted in 6 patients: 2 each at 2, 7, and 10 months. …”
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    Clinical Outcomes of Upper Gastrointestinal Stents and Review of Current Literature
  15. 5875
    “…Additionally, all stent-grafts were patent and did not migrate, and there was no thrombus in the lumens of stent-grafts. …”
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    Safety and Feasibility Study of a Novel Stent-Graft for Thoracic Endovascular Aortic Repair: a Canine Model Experiment
  16. 5876
    por Okur, Volkan, Chung, Wendy K.
    Publicado 2017
    “…With advances in next-generation sequencing technologies and the elimination of gene patents for evaluating genetic information, we are now able to analyze multiple genes simultaneously, leading to the widespread clinical use of gene panels for germline cancer testing. …”
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    The impact of hereditary cancer gene panels on clinical care and lessons learned
  17. 5877
    “…Comparisons of the number of published articles and patents regarding these different types of stresses, and the number of commercially released crops designed to tolerate different types of stresses, revealed a huge gap in the bench-to-field transfer rate of abiotic stress-tolerant crops, as compared to crops designed to tolerate biotic stress. …”
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    To Produce or to Survive: How Plastic Is Your Crop Stress Physiology?
  18. 5878
    “…It also discusses the hurdles to commercialization of these techniques despite several patent applications owing to the ambiguous legal status of genome-editing methods on account of their disputed classification. …”
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    Advances in genome editing for improved animal breeding: A review
  19. 5879
    “…Via homology modelling we predicted and confirmed an integral role of arginine(172), located in the 2nd extracellular loop, in the action of decanoic acid but not of 3,3′-diindolylmethane. Exemplars from a patented series of GPR84 antagonists were able to block agonist actions of both decanoic acid and 3,3′-diindolylmethane at GPR84. …”
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    Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
  20. 5880
    “…Endotracheal intubation in rabbits can be challenging due to their unusual anatomy. Achieving a patent airway during anesthesia is critical for the avoidance of airway obstruction, prevention of gastric tympany, and to allow ventilatory support. …”
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    Endotracheal Intubation of Rabbits Using a Polypropylene Guide Catheter
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