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  1. 6501
    “…RESULTS: A total of 159 associated extracardiac vascular deformities were confirmed by surgery. Patent ductus arteriosus (36, 22.64%), right-sided aortic arch (29, 18.24%), and pulmonary valve stenosis (23, 14.47%) were the most common associated extracardiac vascular abnormalities. …”
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    Assessment of tetralogy of Fallot–associated congenital extracardiac vascular anomalies in pediatric patients using low-dose dual-source computed tomography
  2. 6502
    “…As NSC319726 was first shown to have anti-cancer activity, its affects against human pathogenic fungi establish NSC319726 as a repurposed, off-patent compound that has potential antifungal activity. …”
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    Repurposing an inhibitor of ribosomal biogenesis with broad anti-fungal activity
  3. 6503
    “…The first results of treatments with checkpoint inhibitors are presented. With the patent expiry of trastuzumab, a number of study results for trastuzumab biosimilars have also been published. …”
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    Update Breast Cancer 2017 – Implementation of Novel Therapies
  4. 6504
    “…In addition to the theoretical point of view, these data are of interest from the applied point of view, supporting a novel strategy to inhibit BCL11A by mimicking miR-210 functions, accordingly with the concept supported by several papers and patent applications that inhibition of BCL11A is an efficient strategy for fetal hemoglobin induction in the treatment of β-thalassemia.…”
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    BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression
  5. 6505
    “…BACKGROUND: There are few data on the mechanism of recurrent neurological events after transcatheter closure of patent foramen ovale (PFO) in cryptogenic stroke or TIA. …”
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    Recurrent Stroke after Transcatheter PFO Closure in Cryptogenic Stroke or Tia: Long-Term Follow-Up
  6. 6506
    “…Perioperative transesophageal echocardiography (TEE) confirmed diagnosis and excluded presence of patent foramen ovale (PFO). Surgical removal was done successfully with complete resolution of ST-segment elevation and rapid fall of cardiac enzymes to normal levels. …”
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    STEMI Due to Big Ostial Left Main Thrombus Extending Into Aorta: Challenging Situation With No Clear Guidelines
  7. 6507
    “…The patient showed prompt resolution of patent infection by microscopy but remained positive by molecular methods for > 30 days after treatment initiation. …”
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    Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease
  8. 6508
    “…MATERIALS AND METHODS: In this prospective observational trial, 20 patients were enrolled. Two patients had a patent foramen ovale on transesophageal echocardiography and were excluded from the study. …”
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    Effects of Crystalloid Preloading (20 ml/kg) on Hemodynamics in Relation to Postural Changes in Patients Undergoing Neurosurgical Procedures in Sitting Position
  9. 6509
    “…With the expiration and overturning of the BRCA patents, limitations on which laboratories could offer commercial testing were lifted. …”
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    Clinical testing of BRCA1 and BRCA2: a worldwide snapshot of technological practices
  10. 6510
    “…He had congenital atrial and ventricular septal defects and patent ductus arteriosus, which had been repaired previously. …”
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    Transient cardiac arrest in a child with Down syndrome during anesthesia induction with sevoflurane: a case report
  11. 6511
    “…Upon examination, computed tomography showed a 4.5 × 3.3 cm heterogeneous, enhancing right renal mass with a patent renal vein. Magnetic resonance imaging confirmed a T1/T2 hypointense, diffusion-restricting, right mid-renal mass that was fluorodeoxyglucose-avid on positron emission tomography. …”
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    Primary Nocardia Infection Causing a Fluorodeoxyglucose-Avid Right Renal Mass in a Redo Lung Transplant Recipient
  12. 6512
    “…Control cavographies showed patent inferior vena cavas. Pathological examination indicated little inflammatory tissue response. …”
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    In vivo evaluation of a new vena cava filter
  13. 6513
    “…AIMS: Familial hypercholesterolaemia (FH) is a vastly under-diagnosed genetic disorder, associated with early development of coronary heart disease and premature mortality which can be substantially reduced by effective treatment. Patents have recently expired on high-intensity statins, reducing FH treatment costs. …”
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    Cost effectiveness of cascade testing for familial hypercholesterolaemia, based on data from familial hypercholesterolaemia services in the UK
  14. 6514
    “…Here, an in silico drug screening and the following cell-based screening to measure the TRPV2 activation were carried out in HEK293 cells expressing TRPV2 using lead compounds (tranilast or SKF96365) and off-patent drug stocks. We identified 4 chemical compounds containing amino-benzoyl groups and 1 compound (lumin) containing an ethylquinolinium group as candidate TRPV2 inhibitors. …”
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    Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model
  15. 6515
    “…Hyperoxia-induced acute lung injury (HALI) as one of the most common complications in patents on mechanical ventilation, and there are no efficient methods to overcome this at present. …”
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    miR-21-5p regulates type II alveolar epithelial cell apoptosis in hyperoxic acute lung injury
  16. 6516
    “…To address such limitation, we built a microelectrode array (hyperdrive, patent US5928143 A) compatible with wide-field imaging that allows insertion of up to 12 probes into a large brain area (8 mm diameter). …”
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    High-performance, inexpensive setup for simultaneous multisite recording of electrophysiological signals and mesoscale voltage imaging in the mouse cortex
  17. 6517
    “…JinQi Jiangtang (JQJT) tablets, a Chinese patent medicine approved by the State Food and Drug Administration, are composed of Coptidis Rhizoma, Astragali Radix, and Lonicerae Japonicae Flos, and have a significant effect on diabetes. …”
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    Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma
  18. 6518
    “…Other computational parameters were also computed such as choice consistency and subjective reward valuation. RESULTS: Patents and controls did not differ in their subjective valuation of reward. …”
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    S76. A BEHAVIOURAL ECONOMIC ANALYSIS OF EFFORT-RELATED CHOICE IN SCHIZOPHRENIA
  19. 6519
    “…OUTCOMES: After surgery, the aneurysm disappeared, and the graft was patent. Postoperative computed tomography and computed tomography angiography indicated a cranial defect and graft patency. …”
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    Treatment of giant cavernous aneurysm in an elderly patient via extracranial–intracranial saphenous vein bypass graft in a hybrid operating room: A case report
  20. 6520
    “…Since the vast majority of prescription drugs consumed by Americans are off patent (‘generic’), their regulation and supply is of wide interest. …”
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    The generic drug user fee amendments: an economic perspective
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