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  1. 8461
    “…DISCLOSURES: Simon C and Aguilar-Gallardo C are co-inventors of the International Patent Application No. PCT/EP2011/004941 entitled “Methods for tumor treatment and adipogenesis differentiation”. …”
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    Transdifferentiation of MALME-3M and MCF-7 Cells toward Adipocyte-like Cells is Dependent on Clathrin-mediated Endocytosis
  2. 8462
    por Kotwani, Anita
    Publicado 2013
    “…Availability of generic medicines was much higher in the private sector. Off-patented medicines, like diazepam, diclofenac, and doxycycline had the highest MPRs. …”
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    Where are we now: assessing the price, availability and affordability of essential medicines in Delhi as India plans free medicine for all
  3. 8463
    por Ghate, Utkarsh, Kulkarni, Hema
    Publicado 2012
    “…The pharmaceutical companies do not invest in the market “at the bottom of the pyramid” due to thin margins/ loss risk. Thus, of the patented malaria medicine developed by National Research Development Council (NRDC) named “Ayush 64” (www.nrdcindia.com/pages/ayush64.htm), hardly any companies bought marketing rights or did many sales. …”
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    PA01.56. Malaria cure by Herbal / Ayurvedic Medicine in Central Indian tribal belt
  4. 8464
    “…“Few side effects” (49.6%) was the main reason of CAM use; whereas “doubt of effect” (61.5%) was the main reason for non-use. Patent herbal medicine (90.7%) was the most commonly used CAM type. …”
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    Features of complementary and alternative medicine use by patients with coronary artery disease in Beijing: a cross-sectional study
  5. 8465
    “…METHODS: 60 patients (mean age 13.3 ± 6.8 years) after the Fontan procedure without patent tunnel fenestration underwent CMR as part of their routine clinical assessment that included ventricular functional analysis and flow measurements in the inferior vena cava (IVC), superior vena cava (SVC) and ascending aorta (Ao). …”
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    Aortopulmonary Collateral Flow Is Related to Pulmonary Artery Size and Affects Ventricular Dimensions in Patients after the Fontan Procedure
  6. 8466
    “…IgG responses against SjCyP18 were found in some S. japonicum infected patients and were significantly induced when infection become patent and produce eggs in infected mice. Furthermore, the Th2-promoting subclass of IgG1 was the predominant isotype in S. japonicum infected mice. …”
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    Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice
  7. 8467
    “…Multivariate regression analysis resulted in a final model, including SNAP, gestational age, apnea of prematurity, patent ductus arteriosus, and surfactant use as independent risk factors, with a higher predictive accuracy compared with individual components (AUC =0.92; 95% CI, 0.87-0.96; p <0.001). …”
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    Addition of SNAP to perinatal risk factors improves the prediction of bronchopulmonary dysplasia or death in critically ill preterm infants
  8. 8468
    “…The present study set out to assess the efficacy of Cervidil®, a patented dinoprostone (PgE(2))-containing vaginal insert with a controlled-release mechanism, to safely induce sufficient cervical dilation for the purpose of transcervical embryo transfer (TCET) in cyclic ewes. …”
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    Induction of cervical dilation for transcervical embryo transfer in ewes
  9. 8469
    “…In cases undergoing bilateral VV with only SHST, patency rates were 90.9%, and both cases of unilateral EV were patent (100%). Conclusions: VV was successful in 90.9% of patients undergoing VR in the setting of SHST alone. …”
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    The significance of sperm heads and tails within the vasal fluid during vasectomy reversal
  10. 8470
    “…In Scotland, generic risperidone was only 16% of pre-patent loss prices versus 72% in Ireland. CONCLUSION: Consistent findings of no increased prescribing of risperidone post generics with limited specific demand-side measures suggests no ‘spillover’ effect from one class to another encouraging the preferential prescribing of generic atypical antipsychotic drugs. …”
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    Can authorities appreciably enhance the prescribing of oral generic risperidone to conserve resources? Findings from across Europe and their implications
  11. 8471
    “…PURPOSE: The objective of this pilot trial was to evaluate the safety and efficacy of AKL1, a patented botanical formulation containing extracts of Picrorhiza kurroa, Ginkgo biloba, and Zingiber officinale, as add-on therapy for patients with chronic obstructive pulmonary disease (COPD) and chronic cough. …”
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    Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease
  12. 8472
    “…This led us to thoroughly investigate (i) mechanical and thermal sensory alterations, (ii) responses to acute treatments with drugs having patent or potential anti-allodynic properties and (iii) the spinal/ganglion expression of transcripts encoding markers of neuronal injury, microglia and astrocyte activation in rats that underwent complete spinal cord transection (SCT). …”
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    Spinal Cord Transection-Induced Allodynia in Rats – Behavioral, Physiopathological and Pharmacological Characterization
  13. 8473
    por Daemmrich, Arthur, Mohanty, Ansuman
    Publicado 2014
    “…In both countries, generics will increase their share of all prescriptions, but economic and structural incentives for new drug invention and brand-name prescribing by physicians will keep the share of patented drug sales high compared to countries with more direct government control over the pharmaceutical market. …”
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    Healthcare reform in the United States and China: pharmaceutical market implications
  14. 8474
    “…The present study included atorvastatin users as an unexposed control group because atorvastatin was patent-protected and thus not substitutable. We assessed refill adherence using continuous measure of medication acquisition (CMA). …”
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    Effects of generic substitution on refill adherence to statin therapy: a nationwide population-based study
  15. 8475
    “…However, three patients underwent transvenous obliteration due to bleeding despite a patent TIPS that had been previously placed. The average time from TIPS placement to transvenous obliteration was 125 days (range: 3-324 days). …”
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    Management of Bleeding Duodenal Varices with Combined TIPS Decompression and Trans-TIPS Transvenous Obliteration Utilizing 3% Sodium Tetradecyl Sulfate Foam Sclerosis
  16. 8476
    por Oh, Hyun, Yoon, Jong-Man
    Publicado 2014
    “…There is a need to understand the genetic traits and composition of three mollusk species in order to evaluate exactly the patent genetic effect. PCR analysis was performed on DNA samples extracted from a total of 21 individuals using seven decamer oligonucleotides primers. …”
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    Genetic Distances of Three Mollusk Species Investigated by PCR Analysis
  17. 8477
    “…The proportion of sub-patent infections increased with increasing age and with decreasing prevalence across villages. …”
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    Epidemiology of forest malaria in Central Vietnam: the hidden parasite reservoir
  18. 8478
    “…A total of 16 (19.28%) complication were reported in these patents. Commonly reported complication included dysphagia, pleural effusion and anastomotic leak. …”
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    Robotic transthoracic esophagectomy
  19. 8479
    “…The VWF/ADAMTS13 ratio showed a significant increase on 1POD, which persisted until 7POD. None of patents was diagnosed as AKI based on AKIN criteria, although two patients received furosemide and/or carperitide therapy because of decreased urine output less than 0.5 ml/kg/h for several hours in ICU. …”
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    Increased prothrombotic property as a risk factor of acute kidney injury after surgical repair of abdominal aortic aneurysm: a prospective observational study
  20. 8480
    por Lexchin, Joel
    Publicado 2015
    “…The purpose of this study is to compare Health Canada's use of priority reviews to therapeutic ratings from two independent organisations, the Patented Medicine Prices Review Board (PMPRB) and the French drug bulletin Prescrire International, over the period 1 January 1997–31 December 2012. …”
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    Health Canada's use of its priority review process for new drugs: a cohort study
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