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  1. 2881
    “…The DMR analysis combined results from the feature-specific analysis for a specific chromosome and using distances between features as weights whereas FL regression combined two penalties to encourage sparsity of single features and the difference between two consecutive features. …”
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    Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study
  2. 2882
    “…CONCLUSIONS: This study shows that interpolation-based offset correction reduces the offset with comparable efficacy as phantom measurement phase offset correction, without the time penalty imposed by phantom scans. TRIAL REGISTRATION: The study was registered in The Netherlands National Trial Register (NTR) under TC 4865. …”
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    In-vivo validation of interpolation-based phase offset correction in cardiovascular magnetic resonance flow quantification: a multi-vendor, multi-center study
  3. 2883
    “…Overall, the ILs were high yielding under various stresses and importantly they also performed well in non-stress conditions without any yield penalty. CONCLUSION: The current study clearly illustrated the success of MAS in combining tolerance to multiple biotic and abiotic stresses while maintaining higher yield potential and preferred grain quality. …”
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    Marker Assisted Forward Breeding to Combine Multiple Biotic-Abiotic Stress Resistance/Tolerance in Rice
  4. 2884
    “…RESULTS: We propose unsupervised medical anomaly detection generative adversarial network (MADGAN), a novel two-step method using GAN-based multiple adjacent brain MRI slice reconstruction to detect brain anomalies at different stages on multi-sequence structural MRI: (Reconstruction) Wasserstein loss with Gradient Penalty + 100 [Formula: see text] loss—trained on 3 healthy brain axial MRI slices to reconstruct the next 3 ones—reconstructs unseen healthy/abnormal scans; (Diagnosis) Average [Formula: see text] loss per scan discriminates them, comparing the ground truth/reconstructed slices. …”
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    MADGAN: unsupervised medical anomaly detection GAN using multiple adjacent brain MRI slice reconstruction
  5. 2885
    “…However, the combined requirements of overcoming the fundamental biomechanical differences between the two gaits and minimizing the metabolic penalty of the exoskeleton mass make it challenging to develop an exoskeleton that can reduce the metabolic energy during both gaits. …”
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    Reducing the metabolic energy of walking and running using an unpowered hip exoskeleton
  6. 2886
    “…Objective performance measures included the total number of repetitions to reach proficiency, and total performance scores (i.e. time + error penalties across all repetitions) in training and testing. …”
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    Laparoscopic skills training: the effects of viewing mode (2D vs. 3D) on skill acquisition and transfer
  7. 2887
    “…Interestingly, the enhancement in 2AP in the vegetative stage also helped to accumulate it in mature grains (twofold in A-157 and 1.5 fold in B-370) without test weight penalty. The study indicated that the ornithine and proline together along with methylglyoxal contribute towards the enhancement of 2AP under salt stress.…”
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    Co-functioning of 2AP precursor amino acids enhances 2-acetyl-1-pyrroline under salt stress in aromatic rice (Oryza sativa L.) cultivars
  8. 2888
    “…The most informative variables were selected using an unsupervised lasso-type penalty selection for sparse clustering. Hierarchical clustering was performed using Pearson correlation as the distance metric and WARD.D2 as the clustering method. …”
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    Clinical, Virological and Immunological Subphenotypes in a Cohort of Early Treated HIV-Infected Children
  9. 2889
    “…This work presented a typical genomics-assisted breeding strategy and practice, which involves in directional introgression and rapid stack of multiple disease resistance genes, endowing the super-high-yield hybrid rice variety with holistic disease resistance but without yield penalty.…”
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    Genomics-Assisted Improvement of Super High-Yield Hybrid Rice Variety “Super 1000” for Resistance to Bacterial Blight and Blast Diseases
  10. 2890
    “…The three most predictive variables in the LASSO model were selected from 17 PFASs, which was based on the optimal penalty coefficient (λ = 0.0218) identified with the minimum criterion. …”
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    Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
  11. 2891
    “…These models include Cox regression, penalized Cox regression (with Ridge, LASSO, and elastic net penalties), survival trees, random survival forests, survival support vector machines, artificial neural networks, and extreme gradient boosting. …”
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    Dementia risk prediction in individuals with mild cognitive impairment: a comparison of Cox regression and machine learning models
  12. 2892
    “…Developing salinity-tolerant varieties is critical for minimizing economic penalties caused by salinity and providing solutions for global food security. …”
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    HvNCX, a prime candidate gene for the novel qualitative locus qS7.1 associated with salinity tolerance in barley
  13. 2893
    “…BACKGROUND: To support a victim of violence and establish the correct penalty for the perpetrator, it is crucial to correctly evaluate and communicate the severity of the violence. …”
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    Removing Biases in Communication of Severity Assessments of Intimate Partner Violence: Model Development and Evaluation
  14. 2894
    “…These high readmission rates harm patient outcomes and financially strain healthcare institutions, inviting penalties and discouraging potential patients. Enhancing inpatient care, care transitions, and case management is crucial to lowering readmissions. …”
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    The Path to Sustainable Healthcare: Implementing Care Transition Teams to Mitigate Hospital Readmissions and Improve Patient Outcomes
  15. 2895
    “…Even when the power benefit was negligible, the use of [Formula: see text] carried no statistical penalty. Congruent with theory and simulations, [Formula: see text] showed in our experiments an average 21% statistical power improvement with respect to MR(gluc) and 10% with respect to K(i) (approximately 20% savings in sample size). …”
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    The power of FDG-PET to detect treatment effects is increased by glucose correction using a Michaelis constant
  16. 2896
    “…Based on in-source laser-induced reduction of chelated Cu(II) to Cu(I), we now demonstrate the following ranking with respect to the chemical inertness of their complexed Cu ions: DOTA-AE105 << CB-TE2A-AE105 < CB-TE2A-PA-AE105, which is correlated to their corresponding demetallation rate. No penalty in the uPAR receptor binding affinity of the targeting peptide was encountered by conjugation to either of the macrobicyclic chelators (IC(50) ~ 5-10 nM) and high yields and radiochemical purities (>95%) were achieved in all cases by incubation at 95ºC. …”
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    Improved PET Imaging of uPAR Expression Using new (64)Cu-labeled Cross-Bridged Peptide Ligands: Comparative in vitro and in vivo Studies
  17. 2897
    “…Health care organizations have struggled to meet expectations and avoid penalties to reimbursements from the Center for Medicare and Medicaid Services (CMS). …”
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    Factors Associated With Adoption of Health Information Technology: A Conceptual Model Based on a Systematic Review
  18. 2898
    “…But despite the importance of improving regulatory arrangements in an attempt to ensure unbiased medicines information, such efforts alone are insufficient because simply improving oversight and increasing penalties fail to address additional layers of industry bias.…”
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    Complaints, Complainants, and Rulings Regarding Drug Promotion in the United Kingdom and Sweden 2004–2012: A Quantitative and Qualitative Study of Pharmaceutical Industry Self-Regulation
  19. 2899
    “…BACKGROUND: ECMO recipients who develop bloodstream infections (BSI) meeting CLABSI criteria are publically-reported in inter-facility comparisons and contribute to potential penalties from CMS. We aimed to determine the incidence of BSI, specifically CLABSI, following receipt of ECMO at one of the largest ECMO centers in the US. …”
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    To Be a CLABSI or Not to Be a CLABSI—That Is the Question: The Epidemiology of Bloodstream Infections in a Large ECMO Population
  20. 2900
    “…In addition, annual licensing and an reaccreditation system with comprehensive monitoring should be enforced, using penalties for non-compliant pharmacies as possible incentives for appropriate dispensing practices. …”
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    Effectiveness of an educational intervention to improve antibiotic dispensing practices for acute respiratory illness among drug sellers in pharmacies, a pilot study in Bangladesh
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