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181por Azam, Faizul, Abugrain, Ismaiel Mohamed, Sanalla, Mohamed Hussin, Elnaas, Radwan Fatahalla, Rajab, Ibrahim Abdassalam Ibn“…In this regard, computational tools have helped medicinal chemists modify and optimize molecules to potent drug candidates with better pharmacokinetic profiles, and guiding biologists and pharmacologists to explore new disease genes as well as novel drug targets. …”
Publicado 2013
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182por Mussarat, Sakina, Amber, Rahila, Tariq, Akash, Adnan, Muhammad, AbdElsalam, Naser M., Ullah, Riaz, Bibi, Roqaia“…We invite the attention of pharmacologists and chemists for further exploration of plants having high Fic, FL, and PR values in the present study. …”
Publicado 2014
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183por Huang, Lin, Xie, Duoli, Yu, Yiran, Liu, Huanlong, Shi, Yan, Shi, Tieliu, Wen, Chengping“…It has been highly recognized among pharmacologists and scholars in TCM researches. The latest release, TCMID 2.0 (http://www.megabionet.org/tcmid/), replenished the preceding database with 18 203 herbal ingredients, 15 prescriptions, 82 related targets, 1356 drugs, 842 diseases and numerous new connections between them. …”
Publicado 2018
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184por Juliana, Fidiniaina Rina, Kesse, Samuel, Boakye-Yiadom, Kofi Oti, Veroniaina, Hanitrarimalala, Wang, Huihui, Sun, Meihao“…The human eye’s peculiar and exclusive anatomy and physiology continue to pose a significant obstacle to researchers and pharmacologists in the provision of efficient drug delivery. …”
Publicado 2019
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185por Hardman, Tim, Caplain, Henri, Rottey, Sylvie, Douglas, Desiree, Stringer, Steffan, Sourgens, Hildegard“…The conference focused on how the landscape around early clinical development is changing and how clinical pharmacologists might prepare for these changes. A preconference workshop gave consideration to the impact that modeling and simulation, including physiology-based pharmacokinetic strategies, is having on the practice of clinical development. …”
Publicado 2019
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186“…We hope this review helps clinical pharmacologists to understand the underlying estimation process of CiPA in silico modeling.…”
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187“…The absence of a universally accepted definition has led to confusion, disagreement and misconceptions among physiologists, cardiologists and safety pharmacologists regarding its definition particularly in light of new discoveries regarding the load dependent kinetics of cardiac contraction and their translation to cardiac force-velocity and ventricular pressure-volume measurements. …”
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188por Venisse, Nicolas, Peytavin, Gilles, Bouchet, Stephane, Gagnieu, Marie-Claude, Garraffo, Rodolphe, Guilhaumou, Romain, Solas, Caroline“…For that purpose we call for multi-institutional collaborative work and involvement of clinical pharmacologists in multidisciplinary research consortia.…”
Publicado 2020
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189“…The baseline data on color attributes, betacyanins profile, carotenoids profile, betaxanthins, betalains and antioxidant potentiality obtained in the present study could contribute to pharmacologists for evaluating these components scientifically in A. tricolor.…”
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190por Raphael, Anakwue“…New models of anticoagulation service should include appropriately trained professionals such as Physicians, Pharmacists, Clinical Pharmacologists, Nurses, and Laboratory Scientists who are knowledgeable in diagnostic, management, and monitoring of anticoagulation. …”
Publicado 2020
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191por Ibrahim, Sabrin R. M., Sirwi, Alaa, Eid, Basma G., Mohamed, Shaimaa G. A., Mohamed, Gamal A.“…The goal of this review is to attract the interest of pharmacologists, natural product researchers, and synthetic chemists for discovering novel drug candidates for treating immune-mediated liver injury.…”
Publicado 2021
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192“…Though this notion of VPs is a powerful tool to describe patients’ heterogeneity, the analysis and understanding of these VPs present new challenges to systems pharmacologists. Here, using a model of the hypothalamic–pituitary–adrenal axis, we show that an integrated pipeline that combines machine learning (ML) and bifurcation analysis can be used to effectively and efficiently analyse the behaviors observed in populations of VPs. …”
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193por Gold, Ben, Zhang, Jun, Quezada, Landys Lopez, Roberts, Julia, Ling, Yan, Wood, Madeleine, Shinwari, Wasima, Goullieux, Laurent, Roubert, Christine, Fraisse, Laurent, Bacqué, Eric, Lagrange, Sophie, Filoche-Rommé, Bruno, Vieth, Michal, Hipskind, Philip A., Jungheim, Louis N., Aubé, Jeffrey, Scarry, Sarah M., McDonald, Stacey L., Li, Kelin, Perkowski, Andrew, Nguyen, Quyen, Dartois, Véronique, Zimmerman, Matthew, Olsen, David B., Young, Katherine, Bonnett, Shilah, Joerss, Douglas, Parish, Tanya, Boshoff, Helena I., Arora, Kriti, Barry, Clifton E., Guijarro, Laura, Anca, Sara, Rullas, Joaquín, Rodríguez-Salguero, Beatriz, Martínez-Martínez, Maria S., Porras-De Francisco, Esther, Cacho, Monica, Barros-Aguirre, David, Smith, Paul, Berthel, Steven J., Nathan, Carl, Bates, Robert H.“…We developed a higher order consortium within the TBDA in which four pharmaceutical companies (GlaxoSmithKline, Sanofi, MSD, and Lilly) collectively collaborated with screeners at Weill Cornell Medicine, the Infectious Disease Research Institute (IDRI), and the National Institute of Allergy and Infectious Diseases (NIAID), pharmacologists at Rutgers University, and medicinal chemists at the University of North Carolina to screen ∼8900 β-lactams, predominantly cephalosporins, and characterize active compounds. …”
Publicado 2022
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194por Beeraka, Narasimha M, Zhou, Runze, Wang, Xiaoyan, Vikram P R, Hemanth, Kumar, Tegginamath Pramod, Liu, Junqi, Greeshma, M V, Mandal, Subhankar P, Gurupadayya, B M, Fan, Ruitai“…However, there are very limited reports pertinent to the molecular signaling underlying SSR and making pharmacologists, and formulation scientists to identify the effective therapeutic targets in order to produce novel therapies using novel drug delivery systems (NDDS). …”
Publicado 2022
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195“…Among the predicted anti-COVID-19 drug candidates, some drugs are being clinically studied by pharmacologists, and their binding sites to COVID-19-related protein receptors have been found via the molecular docking technology.…”
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196por Georgieva, Ekaterina, Benkova, Krasimira, Vlaeva, Nadya, Karamalakova, Yanka, Miteva, Radostina, Abrashev, Hristo, Nikolova, Galina“…The review is intended for a wide audience of social workers, toxicologists, and pharmacologists.…”
Publicado 2022
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197Effectiveness of a Multifaced Antibiotic Stewardship Program: A Pre-Post Study in Seven Italian ICUspor Mandelli, Giulia, Dore, Francesca, Langer, Martin, Garbero, Elena, Alagna, Laura, Bianchin, Andrea, Ciceri, Rita, Di Paolo, Antonello, Giani, Tommaso, Giugni, Aimone, Gori, Andrea, Lefons, Ugo, Muscatello, Antonio, Olivieri, Carlo, Pan, Angelo, Pedeferri, Matteo, Rossi, Marianna, Rossolini, Gian Maria, Russo, Emanuele, Silengo, Daniela, Viaggi, Bruno, Bertolini, Guido, Finazzi, Stefano“…Each ICU was visited by a multidisciplinary team involving clinicians, microbiologists, pharmacologists, infectious disease specialists, and data scientists. …”
Publicado 2022
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198“…Pharmacogenetics and genomics are becoming substantially integrated fields of the profession of clinical pharmacology, and education in the relevant methods, knowledge and concepts form an indispensable part of the clinical pharmacology curriculum and the professional life of pharmacologists from early drug discovery to pharmacovigilance.…”
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199“…Moreover, we show that Grad-AAM creates explanations that are consistent with pharmacologists, which may help us gain chemical insights directly from data beyond human perception. …”
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200por De Ponti, Fabrizio“…It is anticipated that a more focused interaction between basic science investigators, pharmacologists, and clinicians will lead to better treatment of IBS.…”
Publicado 2013
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