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661“…The disease spectrum includes a range of manifestations from trivial upper respiratory tract infections to severe invasive pneumococcal disease (PD). The basis of diagnosis is the isolation of bacteria in the culture of body fluids including blood. …”
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662“…Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. …”
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663por Humphreys, Hilary, Corcoran, Mary, Mereckiene, Jolita, Cunney, Robert, Cotter, Suzanne“…The introduction of pneumococcal conjugate vaccines (PCV) into the childhood vaccination programme has reduced invasive pneumococcal disease (IPD). Although anticipated from data elsewhere, surveillance in Ireland has confirmed reductions in IPD amongst those ⩾65 years of age due to a decline of PCV serotypes in this age group. …”
Publicado 2023
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664por Flasche, Stefan, Ojal, John, Le Polain de Waroux, Olivier, Otiende, Mark, O’Brien, Katherine L., Kiti, Moses, Nokes, D. James, Edmunds, W John, Scott, J. Anthony G.“…We fitted a transmission dynamic model to detailed local data, including nasopharyngeal carriage and invasive pneumococcal disease (IPD), to infer the marginal impact of the PCV catch-up campaign over hypothetical routine cohort vaccination in that setting and to estimate the likely impact of alternative campaigns and their dose efficiency. …”
Publicado 2017
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665“…CONCLUSIONS: A PHiD-CV 2+1 universal mass vaccination program could substantially reduce pneumococcal disease burden versus no vaccination, and was expected to be cost-effective in Malaysia. …”
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666por Lehmann, Deborah, Kirarock, Wendy, van den Biggelaar, Anita H. J., Passey, Megan, Jacoby, Peter, Saleu, Gerard, Masiria, Geraldine, Nivio, Birunu, Greenhill, Andrew, Orami, Tilda, Francis, Jacinta, Ford, Rebecca, Kirkham, Lea-Ann, Solomon, Vela, Richmond, Peter C., Pomat, William S.“…BACKGROUND: Children in third-world settings including Papua New Guinea (PNG) experience early onset of carriage with a broad range of pneumococcal serotypes, resulting in a high incidence of severe pneumococcal disease and deaths in the first 2 years of life. …”
Publicado 2017
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667por Suaya, Jose A, Arguedas, Adriano G, Mendes, Rodrigo E, Vojicic, Jelena, Swerdlow, David L, Isturiz, Raul E, Gessner, Bradford D“…CONCLUSION: We found a strong correlation between databases (SENTRY and ABC) and between INV and N-INV pneumococcal disease in the proportion of disease due to PCV13 types. …”
Publicado 2018
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668por Hanquet, Germaine, Krizova, Pavla, Valentiner-Branth, Palle, Ladhani, Shamez N, Nuorti, J Pekka, Lepoutre, Agnes, Mereckiene, Jolita, Knol, Mirjam, Winje, Brita A, Ciruela, Pilar, Ordobas, Maria, Guevara, Marcela, McDonald, Eisin, Morfeldt, Eva, Kozakova, Jana, Slotved, Hans-Christian, Fry, Norman K, Rinta-Kokko, Hanna, Varon, Emmanuelle, Corcoran, Mary, van der Ende, Arie, Vestrheim, Didrik F, Munoz-Almagro, Carmen, Latasa, Pello, Castilla, Jesus, Smith, Andrew, Henriques-Normark, Birgitta, Whittaker, Robert, Pastore Celentano, Lucia, Savulescu, Camelia“…BACKGROUND: Pneumococcal conjugate vaccines (PCVs) have the potential to prevent pneumococcal disease through direct and indirect protection. …”
Publicado 2019
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669por Wilson, Michele R., McDade, Cheryl L., Perdrizet, Johnna E., Mignon, Annick, Farkouh, Raymond A., Wasserman, Matt D.“…METHODS: Using historical incidence (2007–2018) of pneumococcal disease for Belgian children aged < 16 years, observed invasive pneumococcal disease (IPD) trends from surveillance data were used to estimate future disease in a given PCV13- or PCV10-based program. …”
Publicado 2021
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670por Chiavolini, Damiana, Memmi, Guido, Maggi, Tiziana, Iannelli, Francesco, Pozzi, Gianni, Oggioni, Marco R“…CONCLUSIONS: These data suggest Iga, ZmpB and ZmpC as candidate surface proteins responsible for pneumococcal infection and potentially involved in distinct stages of pneumococcal disease.…”
Publicado 2003
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671“…PCV is generally immunogenic for pediatric patients with invasive pneumococcal disease, with an exception for the infecting serotypes. …”
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672“…Pneumococcal conjugate vaccines target the limited subset of the more than 90 known serotypes of Streptococcus pneumoniae responsible for the greatest burden of pneumococcal disease and antibiotic resistance. Following the introduction of these vaccines, serotypes not targeted were able to expand and resistance became more common within these types. …”
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673“…Colonization is the prerequisite to invasive pneumococcal disease, and is particularly frequent and prolonged in children, though the mechanisms underlying this susceptibility are unknown. …”
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674“…Furthermore, much recent research has led to a better understanding of the virulence factors of this pathogen and their role in the pathogenesis of severe pneumococcal disease, including the cardiac complications, as well as the potential role of adjunctive therapy in the management of severely ill cases. …”
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675“…Pneumococcal conjugate vaccines (PCV) targeted against a limited number of serotypes have nonetheless revealed an impressive impact on each manifestation of pneumococcal disease. At the same time, growing evidence of significant non-vaccine type (NVT) replacement disease following implementation of infant PCV programs has raised questions about the long-term viability of PCV immunization strategies and how to optimize PCV formulations. …”
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676“…Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. …”
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677por Okumura, Koichiro, Sato, Yu, Yonekura, Hiroaki, Toki, Noriyoshi, Kuki, Takaie, Watanuki, Satoshi, Nishida, Kenji“…While invasive pneumococcal disease mainly results in bacteremic pneumonia, meningitis or endocarditis, the present case showed that it can also lead to perihepatitis; a blood culture is therefore useful for clarifying the infection route and pathogens in perihepatitis if the patient has no past history of sexual activity, genital symptoms or physical or other findings indicative of pelvic inflammatory disease.…”
Publicado 2020
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678por Purwanto, Diana Shintawati, Loho, Tonny, Tafroji, Wisnu, Mangunatmadja, Irawan, Immanuel, Suzanna, Timan, Ina Susianti, Yusra, Yusra, Safari, Dodi“…Our data provide insights into the epidemiology of invasive pneumococcal disease in Indonesia.…”
Publicado 2020
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679por Dietl, Beatriz, Henares, Desirée, Boix-Palop, Lucía, Muñoz-Almagro, Carmen, Garau, Javier, Calbo, Esther“…In the last decades, several factors related to the host, the microorganism and the antibiotic therapy have been investigated to identify risk factors associated with the development of invasive pneumococcal disease (IPD). Nevertheless, these factors themselves do not explain the risk of developing disease or its severity. …”
Publicado 2021
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680por Toh, Zheng Quan, Quang, Chau, Tooma, Joseph A., Garland, Suzanne M., Mulholland, Kim, Licciardi, Paul V.“…The outcomes of these research programs have had significant global health impacts, highlighting the importance of these vaccines in preventing pneumococcal disease as well as HPV-associated diseases.…”
Publicado 2021
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