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761por Francis, Jacinta P., Richmond, Peter C., Michael, Audrey, Siba, Peter M., Jacoby, Peter, Hales, Belinda J., Thomas, Wayne R., Lehmann, Deborah, Pomat, William S., van den Biggelaar, Anita H. J.“…PspA may be a useful candidate in an infant pneumococcal vaccine to prevent early URT colonisation.…”
Publicado 2016
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762por Gentile, Angela, Rearte, Analía, Von Spetch, Martha, Laban, Celia, Papucci, Santiago Lopez, Badano, Andrea, Ferrario, Claudia, Pereda, Rosana, Flores, Devora, Berry, Diana, Aguilera, Alejandra, Sponton, Norma, Sorhouet, Cecilia, Napoli, Daniela, Devoto, Susana, Vizzotti, Carla“…BACKGROUND: In 2012 the 13-valent conjugated pneumococcal vaccine (PCV-13) was introduced in the National Immunization Program. …”
Publicado 2017
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763por Pfaller, Michael A, Mendes, Rodrigo E, Duncan, Leonard R, Flamm, Robert K, Sader, Helio S“…Increases in S rates could be related to the anti-pneumococcal vaccine PVC-13 introduced in 2010. DISCLOSURES: M. …”
Publicado 2017
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764por Chilson, Erica, Atkinson, Bruce, Hall-Murray, Cassandra, Snow, Vincenza, Schmoele-Thoma, Beate, Isturiz, Raúl E, Scott, Daniel A“…METHODS: In a previously-published phase 3 study of pneumococcal vaccine–naïve adults 60–64 years of age, participants received PCV13 followed by PPSV23 one year later (PCV13/PPSV23) or PPSV23 followed by PCV13 one year later (PPSV23/PCV13). …”
Publicado 2017
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765por Lehmann, Deborah, Kirarock, Wendy, van den Biggelaar, Anita H. J., Passey, Megan, Jacoby, Peter, Saleu, Gerard, Masiria, Geraldine, Nivio, Birunu, Greenhill, Andrew, Orami, Tilda, Francis, Jacinta, Ford, Rebecca, Kirkham, Lea-Ann, Solomon, Vela, Richmond, Peter C., Pomat, William S.“…The final data will inform policy on pneumococcal vaccine schedules in countries with children at high risk of pneumococcal disease by providing direct comparison of an accelerated schedule of 10vPCV and 13vPCV and the potential advantages of PPV following PCV immunization. …”
Publicado 2017
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766por Dolan, Samantha B., Patel, Manish, Hampton, Lee M., Burnett, Eleanor, Ehlman, Daniel C., Garon, Julie, Cloessner, Emily, Chmielewski, Elizabeth, Hyde, Terri B., Mantel, Carsten, Wallace, Aaron S.“…In many countries, the addition of IPV would necessitate delivery of multiple injectable vaccines (hereafter, “multiple injections”) during a single visit, with infants receiving IPV alongside pentavalent vaccine (which covers diphtheria, tetanus, and whole-cell pertussis; hepatitis B; and Haemophilus influenzae type b) and pneumococcal vaccine. Unanticipated concerns emerged from countries over acceptability of multiple injections, sites of administration, and safety. …”
Publicado 2017
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767por Lucia Leal Castro, Aura, Camacho Moreno, Germán, Montañez Ayala, Anita, Varon, Fabio, Alvarez Rodríguez, Camilo, Valderrama, Sandra, Elena Ariza, Beatriz, Pancha, Oscar, Yadira Santana, Ana, Sánchez Flórez, Nella, Reyes Pabón, Patricia, Ruiz, Jaime, Beltrán, Claudia, Emilia, Prieto, Rojas Rojas, Monica Maria“…ST contained in 13-valent conjugate vaccine (PCV13), 23-valent pneumococcal vaccine (PPVS23) and non-vaccine serotypes accounted for 43.9%, 54.9%, and 40.2% of IPD cases, respectively (Figure 1). 83% and 80.7% strains were susceptible to penicillin and ceftriaxone, respectively. …”
Publicado 2019
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768“…We studied the absolute numbers and proportions of B cells and subpopulations in two groups of adult patients with severe CKD pre- and 7 days post-immunization with PCV13: pneumococcal vaccine naïve and previously immunized with PPV23 (over one year ago). …”
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769“…This study evaluated factors associated with pneumococcal disease, pneumococcal vaccine effectiveness, and risk factors for all-cause mortality in hospitalised adults with pneumococcal disease in Singapore. …”
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770por Platt, Heather L., Greenberg, David, Tapiero, Bruce, Clifford, Robert A., Klein, Nicola P., Hurley, David C., Shekar, Tulin, Li, Jianing, Hurtado, Kim, Su, Shu-Chih, Nolan, Katrina M., Acosta, Camilo J., McFetridge, Richard D., Bickham, Kara, Musey, Luwy K.“…This phase 2 study (V114-008; NCT02987972; EudraCT 2016-001117-25) compared safety and immunogenicity of 2 clinical lots of V114 (investigational 15-valent pneumococcal vaccine: 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19F, 19A, 22F*, 23F, 33F*) to 13-valent pneumococcal conjugate vaccine (PCV13) in healthy infants (*serotypes unique to V114). …”
Publicado 2020
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771“…Of those smokers, 332 (50.5%) had been referred to Smoking Counselling and Cessation Service (SCCS) and 289 (43.9%) actually attended it. 991 cases (42%) received Seasonal Influenza Vaccine (SIV) and 938 cases (39.8%) received Pneumococcal Vaccine (PCV). 698 patients (29.6%) had spirometry done before and 423 patients (17.9%) had been admitted to hospital due to acute exacerbation of COPD (AECOPD). …”
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772por Lawrence, Hannah, Pick, Harry, Baskaran, Vadsala, Daniel, Priya, Rodrigo, Chamira, Ashton, Deborah, Edwards-Pritchard, Rochelle C., Sheppard, Carmen, Eletu, Seyi D., Litt, David, Fry, Norman K., Rose, Samuel, Trotter, Caroline, McKeever, Tricia M., Lim, Wei Shen“…These findings suggest that PPV23 vaccination may continue to have an important role in adult pneumococcal vaccine policy, including the possibility of revaccination of older adults.…”
Publicado 2020
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773“…Overall case numbers and pneumococcal vaccine type cases have strongly decreased.…”
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774por Chen, Xiao Rui Catherine, Fu, Sau Nga, Leung, Wing Kit, Ng, Sze Wing Catherine, Kwan, Wing Yan Wendy, Wong, Tseng Kwong, Chan, Pang Fai, Wong, Man Ying Michelle, Ko, Wai Kit Welchie, Liang, Jun, Hui, Ming Tung Eric, Li, Yim Chu, Luk, Wan, Chao, V K David“…A total of 4866 cases (46.9%) received seasonal influenza vaccine (SIV) and 4227 cases (40.7%) received pneumococcal vaccine (PCV). A total of 1983 patients (19.1%) had spirometry test done before and 1327 patients (12.8%) had history of hospital admission due to acute exacerbation of COPD (AECOPD). …”
Publicado 2021
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775por McCollum, Eric D, King, Carina, Ahmed, Salahuddin, Hanif, Abu A M, Roy, Arunangshu D, Islam, ASMD Ashraful, Colbourn, Tim, Schuh, Holly B, Ginsburg, Amy Sarah, Hooli, Shubhada, Chowdhury, Nabidul H, Rizvi, Syed J R, Begum, Nazma, Baqui, Abdullah H, Checkley, William“…METHODS: We prospectively enrolled well, children aged 3–35 months participating in a pneumococcal vaccine evaluation in Sylhet district, Bangladesh between June and August 2017. …”
Publicado 2021
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776por Olarte, Liset, Banerjee, Dithi, Swanson, Douglas S, Tabakh, Jennifer E, Lee, Brian R, Harrison, Christopher J, Selvarangan, Rangaraj“…The odds of colonization were lower in children with persistent asthma (OR 0.4 [95%CI 0.2-0.9]) after adjusting for age, sex, clinic site, smoking exposure, and number of pneumococcal vaccine doses. Colonized patients without asthma were younger than the other groups (Table 1). …”
Publicado 2021
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777por Chang, Anne B., Toombs, Maree, Chatfield, Mark D., Mitchell, Remai, Fong, Siew M., Binks, Michael J., Smith-Vaughan, Heidi, Pizzutto, Susan J., Lust, Karin, Morris, Peter S., Marchant, Julie M., Yerkovich, Stephanie T., O'Farrell, Hannah, Torzillo, Paul J., Maclennan, Carolyn, Simon, David, Unger, Holger W., Ellepola, Hasthika, Odendahl, Jens, Marshall, Helen S., Swamy, Geeta K., Grimwood, Keith“…Our secondary aims are to evaluate the impact of maternal PHiD-CV vaccination on different ALRI definitions and, in a subgroup, the infants' nasopharyngeal carriage of pneumococci and H. influenzae, and their immune responses to pneumococcal vaccine type serotypes and protein D. Methods: We are undertaking a parallel, multicentre, superiority RCT (1:1 allocation) at four sites across two countries (Australia, Malaysia). …”
Publicado 2022
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778por Cui, Yali, Miao, Chenglin, Chen, Wen, Shang, Wenling, Qi, Qianqian, Zhou, Wei, Wang, Xia, Li, Yingying, Yan, Ziyi, Jiang, Yongmei“…However, it is necessary to develop a less expensive, serotype-independent pneumococcal vaccine due to the emergence of nonvaccine-type pneumococcal diseases and the limited effect of vaccines on colonization. …”
Publicado 2022
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779por Shafaghi, Mona, Bahadori, Zohreh, Madanchi, Hamid, Ranjbar, Mohammad Mehdi, Shabani, Ali Akbar, Mousavi, Seyed Fazlollah“…High morbidity and mortality in over one million cases, especially in very young children and the elderly, are the main motivations for pneumococcal vaccine development. Due to the limitations of the currently marketed polysaccharide-based vaccines, non-serotype-specific protein-based vaccines have received wide research interest in recent years. …”
Publicado 2023
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780por Dula, Dingase, Morton, Ben, Chikaonda, Tarsizio, Chirwa, Anthony E, Nsomba, Edna, Nkhoma, Vitumbiko, Ngoliwa, Clara, Sichone, Simon, Galafa, Bridgette, Tembo, Godwin, Chaponda, Mphatso, Toto, Neema, Kamng'ona, Raphael, Makhaza, Lumbani, Muyaya, Alfred, Thole, Faith, Kudowa, Evaristar, Howard, Ashleigh, Kenny-Nyazika, Tinashe, Ndaferankhande, John, Mkandawire, Christopher, Chiwala, Gift, Chimgoneko, Lorensio, Banda, Ndaziona P K, Rylance, Jamie, Ferreira, Daniela, Jambo, Kondwani, Henrion, Marc Y R, Gordon, Stephen B“…INTERPRETATION: This is, to our knowledge, the first human challenge study to test the efficacy of a pneumococcal vaccine against pneumococcal carriage in Africa, which can now be used to establish vaccine-induced correlates of protection and compare alternative strategies to prevent pneumococcal carriage. …”
Publicado 2023
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