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56781por VanScoy, Brian D, Conde, Haley, Mendes, Rodrigo E, Cotroneo, Nicole, Critchley, Ian A, Critchley, Ian A“…BACKGROUND: Tebipenem (TBP), an oral carbapenem in development for treatment of complicated urinary tract infections and acute pyelonephritis, is active vs. uropathogens which produce extended-spectrum beta-lactamases (ESBLs) such as Escherichia coli (Ec) and Klebsiella pneumoniae (Kp). Bacteria acquire resistance to antibiotics via multiple routes, including by chromosomal mutation. …”
Publicado 2022
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56782por Mack, Andrew R, Bethel, Christopher, Marshall, Steven, Patel, Robin, Patel, Robin, van Duin, David, Fowler, Vance G, Rhoads, Daniel D, Jacobs, Michael, van den Akker, Focco, Six, David A, Moeck, Greg, Papp-Wallace, Krisztina M, Bonomo, Robert A“…MIC50 and MIC90 values (μg/mL) and percent susceptibility for Klebsiella pneumoniae strains (n=200). AMK, amikacin; CST, colistin; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FEP, cefepime; FTB, cefepime-taniborbactam; MEM, meropenem; MVB, meropenem-vaborbactam; TGC, tigecycline. * The breakpoint for CST is intermediate, as no susceptible breakpoint is available. ** The susceptible-dose-dependent breakpoint for FEP alone was provisionally applied to FTB, where taniborbactam was fixed at 4 μg/mL. …”
Publicado 2021
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56783por Mack, Andrew R, Bethel, Christopher, Marshall, Steven, Patel, Robin, Patel, Robin, van Duin, David, Fowler, Vance G, Rhoads, Daniel D, Jacobs, Michael, van den Akker, Focco, Six, David A, Moeck, Greg, Papp-Wallace, Krisztina M, Bonomo, Robert A“…[Image: see text] MIC50 and MIC90 values (µg/mL) and percent susceptibility for Klebsiella pneumoniae strains (n=200). AMK, amikacin; CST, colistin; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FEP, cefepime; MEM, meropenem; MVB, meropenem-vaborbactam; CTB, ceftibuten; TGC, tigecycline. * The breakpoint for CST is intermediate, as no susceptible breakpoint is available. ** The CTB breakpoint is valid only for urinary tract isolates. *** The breakpoint for CTB was provisionally used for CTB/VNRX-5236, where VNRX-5236 was fixed at 4 µg/mL. …”
Publicado 2021
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56784por Castanheira, Mariana, Castanheira, Mariana, Streit, Jennifer M, Sader, Helio S, Shortridge, Dee“…CONCLUSION: In a global surveillance, ECL is the second most common Enterobacterales species/species complex displaying MDR and carbapenem-resistance phenotypes, behind only Klebsiella pneumoniae. Meropenem-vaborbactam and ceftazidime-avibactam can be important options to treat infections caused by MDR ECL. …”
Publicado 2021
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56785por Castanheira, Mariana, Castanheira, Mariana, Doyle, Timothy B, Kantro, Valerie, Mendes, Rodrigo E, Shortridge, Dee“…The top four most common species in the collection were K. pneumoniae (16 isolates) followed by E. cloacae (9), E. coli (8), and K. aerogenes (8). …”
Publicado 2021
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56786por Mendes, Rodrigo E, Critchley, Ian A, Cotroneo, Nicole, Streit, Jennifer M, Sader, Helio S, Castanheira, Mariana, Castanheira, Mariana“…BACKGROUND: Enterobacterales (ENT)—especially Escherichia coli (EC), Klebsiella pneumoniae (KPN), and Proteus mirabilis (PM)—are widely implicated in urinary tract infections (UTIs). …”
Publicado 2021
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56787por Castanheira, Mariana, Castanheira, Mariana, Deshpande, Lalitagauri M, Doyle, Timothy B, Mendes, Rodrigo E, Sader, Helio S“…Isolates submitted to whole genome sequencing were: (1) Escherichia coli (EC) and Klebsiella pneumoniae (KPN; n=817) displaying MIC values ≥2 mg/L for at least 2 of the following β-lactams: ceftazidime, ceftriaxone, aztreonam, or cefepime; (2) Enterobacter cloacae (ECL) and Citrobacter spp. …”
Publicado 2021
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56788“…Most of these isolates were K. aerogenes (n=42), K. pneumoniae (32), and E. cloacae (32), but 13 other species also were carbapenemase negative. …”
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56789por Sader, Helio S, Castanheira, Mariana, Castanheira, Mariana, Huband, Michael D, Shortridge, Dee, Carvalhaes, Cecilia G, Mendes, Rodrigo E“…The top 3 GP organisms were SA, EF, and BHS in the US; SA, EF, and EFM in W-EU; and SA, S. pneumoniae, and BHS in E-EU. Dalbavancin was highly active against methicillin-susceptible (MSSA) and -resistant (MRSA) SA, with an MIC(90) of 0.03 mg/L in all 3 regions (Table). …”
Publicado 2021
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56790por Sader, Helio S, Duncan, Leonard R, Castanheira, Mariana, Castanheira, Mariana, Mendes, Rodrigo E“…(ESP), 22 viridans group streptococci (VGS), and 5 S. pneumoniae. Bacteria were identified by standard algorithms and MALDI-TOF-MS. …”
Publicado 2021
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56791por Sweeney, Yvonne, O’Neill, Hugh, Duffy, Garry, Creegan, Daniel, Bustos, Viviana, Harvey, Brian J., Dalphy, Alexander, O’Grady, Anthony, Kay, Elaine, Samelska, Katarzyna, Izdebska, Justyna, Kurowska, Anna, Al-Zubaidy, Rena, Mroz, Magdalena, Harvey, Brian, Fagan, Ryan, French, Helen, Cuddy, Vanessa, Ashton, Jennifer, Clarke, Michelle, Sayedalamin, Zaid, Baig, Mukhtiar, Almutairi, Osama, Allam, Hassan, Halawa, Taher F., Atta, Hazem M., Sirone, Linda, Erts, Renars, Pavare, Jana, Richter, Louis, Morris, Joseph, Oglesby, Irene, Dunne, Eimear, Kenny, Dermot, Khayyat, Ibrahim Mohammed Mahdi, Salgado, Viviana Bustos, Harvey, Brian J., Tan, Jonavan, Moneley, Daragh, Leahy, Austin, Fitzgerald, Patricia, Fennelly, Evelyn, Harkin, Grace, Lee, John, O’Sullivan, Erica, Kirby, Brian, O’Neill, Sarah, Gonciar, Diana, Mocan, Teodora, Matea, Cristian, Mocan, Lucian, Iancu, Cornel, Doran, Chloe, Hoolahan, Sarah, Engel, Tobias, Alkhattab, Maha, Alekseeva, Tijna, Lackington, William, O’Brien, Fergal, Moollan, Nabeehah, Doran, Chloe, McElvaney, Noel Gerry, Gunaratnam, Cedric, Scanlon, Lorraine, Brady, Noeleen, Timmons, Suzanne, Bresler, Richard, Abreu, Zita, Trohonel, Stefan, Bargman, Joanne, Mirza, Ahmad A., Badrek-Amoudi, Ahmed, Aun, Rakan H., Senan, Hussam A., Mirza, Abdulrahim A., Binsaad, Mohammed S., Farooq, Mian U., Nandi, Saheli, D’Orsi, Beatrice, Prehn, Jochen, Zharova, Mariia, Umrukhin, Pavel, Evans-Uhegbu, Wendy, Doyle, Frank, Kudryashova, Hope, Dorris, Derek, Cummins, Anthony, Doheny-Shanley, Jemma, Woodward, Mark, Hayes, Wesley, Yostos, Marina, Cotter, David, Focking, Melanie, Stancu, Samantha, Iordache, Florin, Popescu, Bogdan A., Akanmu, Muhammad-Mujtaba A., Robert, Alero A., Oridota, Ezekiel O., Mirza, Ahmad A., Alzahrani, Ali K., Alfarhan, Omar, Eldin, Essam Nour, MacManus, Bronagh, Keane, Owen, Hillery, Patrick, Lee, James, O’Reilly, Hugh, Collins, Niamh, Abu saq, Ibrahim, Al Mufarrih, Abdullah, Jaafari, Muath, Al Mahayni, Abdullah, Bawazir, Amen, Alkhateeb, Sultan, Dhannoon, Amenah, Vareslija, Damir, Hill, Arnold, Young, Leonie, Donoghue, Declan, Walsh, Criona, McCabe, Aileen, Pope, John, Pasco, Saturnino, Fallon, Caroline, Solanki, Don, Kiernan, Fiona, Galvin, Sinead, Mucvimicc, Jquan, Mulvihill, Johanna, Mirza, Ahmad A., Elmosry, Soha A., De Souza, Lorenza Andres Ameida, de Oliveira, Yuri, Menezes, Diego, Santos, Alene Vanessa, Asraf, Ahmad Zaki, Stallings, Raymond, Piskareva, Olga, Conlon, Ross, Sweeney-Landers, Siún, Burke, Cathy, Behan, Paraic, Sreenan, Seamus, Organjee, Ahmed, Crosbie-Staunton, Tatsiana, Reeves, Emer, McElvaney, Noel, Mieres, Crystal, Young, Leonie, Charmsaz, Sara, Al-Jalamdeh, Aya, Corcoran, Mary, McElligott, Martha, Stevens, Niall, Humphreys, Hilary, Barnawi, Rashid, Ghurab, Abdulaziz, Alfaer, Sultan, Balubaid, Hassan, Hanbazazah, Kamal, Bukhari, Mohammed, Alsakkaf, Mohammed, Mirza, Ahmad, Mohammed, Amrallah, Pratanata, Anastasia, Nathania, Maria, Annisa, Tsabita, Dewi, Beti, Lee, Kuok Zhen, Carroll, Tomas P., Fee, Laura, McElvaney, Noel G., White, Rachel C., Brady, Robert T, O’Brien, Fergal“…Elmosry P28: Evaluation of the antitumor potential from extracts of endemic plants of Brazilian caatinga against melanoma and hepatocarcinoma Lorenza Andres Ameida De Souza, Yuri de Oliveira, Diego Menezes, Alene Vanessa Santos P29: The role of Chromogranin A as a biomarker in drug resistant neuroblastoma Ahmad Zaki Asraf, Raymond Stallings, Olga Piskareva, Ross Conlon P30: Membrane sweep at term gestation in CUMH; a case-control study Siún Sweeney-Landers, Cathy Burke P31: Study of the variability of glucose levels in patients with diabetes undergoing continuous glucose monitoring Paraic Behan, Seamus Sreenan P32: Inflammatory cytokine response to decreased plasma alpha-1 antitrypsin levels in individuals with the MZ genotype Ahmed Organjee, Tatsiana Crosbie-Staunton, Emer Reeves, Noel McElvaney P33: Analysing the role of SRC-1 in breast cancer stem cell formation and activity Crystal Mieres, Leonie Young, Sara Charmsaz P34: Screening Streptococcus pneumoniae isolates for virulence genes Aya Al-Jalamdeh, Mary Corcoran, Martha McElligott, Niall Stevens, Hilary Humphreys P35: Assessment of the relevance of admission clerking criteria taught to medical students at King Abdulaziz University to real hospital practice Rashid Barnawi, Abdulaziz Ghurab, Sultan Alfaer, Hassan Balubaid, Kamal Hanbazazah, Mohammed Bukhari P36: Pattern of emergency department visits during Hajj period Mohammed Alsakkaf, Ahmad Mirza, Amrallah Mohammed P37: Anti-Dengue activity of Aspergillus terreus (sulochrin); An in vitro study Anastasia Pratanata, Maria Nathania, Tsabita Annisa, Beti Dewi P38: The comorbidome in alpha-1 antitrypsin deficiency Kuok Zhen Lee, Tomas P. …”
Publicado 2016
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