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“…INTRODUCTION: This retrospective analysis compares the probability of target attainment (PTA) for ceftriaxone, levofloxacin and ceftaroline fosamil against Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae in a representative patient population with moderate-to-severe community-acquired pneumonia (CAP). …”
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“…These findings can not only provide some clues to find new genomic functional elements -- in the areas overlapping with introns, but suggest that “functional constraint” of introns may not be necessarily directly associated with intron loss and gain, and that the real functions are probably still outside of our current knowledge. REVIEWERS: This article was reviewed by Mikhail Gelfand, Michael Gray, and Igor Rogozin. …”
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“…Results found include: 1) The consensus composite sequon for O-glycosylation is: ~(W–S/T–W), where “~” denotes the “not” operator. 2) The consensus sequon for phosphorylation is ~(W–S/T/Y/H–W); although W–S/T/Y/H–W is not an absolute inhibitor of phosphorylation. 3) For linear probability model (LPM) estimation, N-glycosylated sequences are good approximations to non-O-glycosylatable sequences; although N – ~P – S/T is not an absolute inhibitor of O-glycosylation. 4) The selective positioning of an amino acid along the sequence, differentiates the PTMs of proteins. 5) Some N-glycosylated sequences are also phosphorylated at the S/T-site in the N – ~P – S/T sequon. 6) ASA values for N-glycosylated sequences are stochastically larger than those for O-GlcNAc glycosylated sequences. 7) Structural attributes (beta turn II, II´, helix, beta bridges, beta hairpin, and the phi angle) are significant LPM predictors of O-GlcNAc glycosylation. …”
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“…The combined presence of hypertension and vitamin D deficiency increased the probability of developing SVD. Our findings will warrant further prospective studies in the future.…”
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“…Pooling data from different sources in order to obtain higher precision and accuracy of survival-probability estimates is appealing. Nevertheless, survival probabilities of hip replacements vary between the countries. …”
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“…Therefore, a nomogram that can predict survival probability by incorporating epidermal growth factor receptor mutation status and treatments for patients with advanced adenocarcinoma would be highly valuable. …”
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“…We found the largest difference in seed species composition to be between epizoochory (fur and hooves) and endozoochory (gut contents). Probability of plant dispersal through guts and fur was correctly predicted from traits more often than not. …”
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“…We describe a case of probable sporadic Creutzfeldt–Jakob disease in the setting of well-controlled HIV and discuss whether exist, in fact, HIV-related factors that may predispose to the development of prion disease. …”
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“…Analyzing co-occurring high sea level and heavy precipitation in Europe, we show that the Mediterranean coasts are experiencing the highest CF probability in the present. However, future climate projections show emerging high CF probability along parts of the northern European coast. …”
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“…In competing risks setting, we account for death according to a specific cause and the quantities of interest are usually the cause‐specific hazards (CSHs) and the cause‐specific cumulative probabilities. A cause‐specific cumulative probability can be obtained with a combination of the CSHs or via the subdistribution hazard. …”
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“…Our nomograms based on significant clinicopathologic features can well predict the 3‐year and 5‐year survival probability of patients with non‐metastatic chondrosarcoma and assist oncologists in making accurate survival evaluation.…”
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“…Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue – the presumed neural substrate for fear output – signal threat probability in male rats (Wright et al., 2019). Here, we scrutinize the activity vlPAG neurons that decrease firing to danger. …”
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“…However, to date, no nomogram models have been found to predict the probability of 6-month poor outcome after ischemic stroke. …”
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“…Cost/probability biases might activate the behavioral immune system and exacerbate the avoidance of social events. …”
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“…OBJECTIVE: This study measured and analyzed the serum levels of 24‐hydroxycholesterol in patients with probable Alzheimer's disease (AD) and age‐/sex‐matched controls. …”
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“…Compared to individuals with likely CMD and alcohol misuse, those with probable PTSD reported higher levels of stigma-related concerns and barriers to care – although this difference was not significantly different. …”
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