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48541“…Rabeprazole is a proton pump inhibitor that inhibits gastric acid production and increases gastric pH; it is widely used clinically as a treatment option for gastritis and gastric ulcers. …”
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48542por Su-Arcaro, Clover, Liao, Wentian, Bieniek, Katarzyna, Constantino, Maira A., Decker, Savannah M., Turner, Bradley S., Bansil, Rama“…Changing pH impacts both the rheological properties of gastric mucin and also influences the proton (H+)-pumped flagellar motors of H. pylori as well as their anti-pH sensing receptors. …”
Publicado 2023
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48543“…The HA-CDI–COVID-patients were younger (69.9 ± 12.6 vs. 72.5 ± 11.6; p = 0.017), admitted from another hospital (20.5% vs. 2.9; p < 0.001), had antimicrobial therapy before CDI (99.1% vs. 91.3%, p < 0.001), received two or more antibiotics (p = 0.030) during a longer period (p = 0.035), received proton pump inhibitors (95.9% vs. 50.0%, p < 0.001) during a longer period (p = 0.012) and steroids (32.8% vs. 20.4%, p < 0.001). …”
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48544por Mallarino-Haeger, Christina, Watson, Allison, Mahgoub, Umnia, Francis, Lily, Heydari, Maryam, Choudhary, Muaaz, Kempker, Russell R, Schechter, Marcos“…The most common medications with class X rifampin DDIs were proton pump inhibitors (20%) and directly acting oral anticoagulants (5.7%), while those for class D rifampin DDIs were atorvastatin (35%) and clopidogrel (12%). …”
Publicado 2023
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48545por Kothapalli, Kumar S.D., Anthony, Joshua C., Pan, Bruce S., Hsieh, Andrea T., Nathanielsz, Peter W., Brenna, J. Thomas“…Mitochondrial fatty acid carrier, CPT2, was among several genes associated with mitochondrial fatty acid oxidation to be downregulated by high DHA, while the mitochondrial proton carrier, UCP2, was upregulated. TIMM8A, also known as deafness/dystonia peptide 1, was among several differentially expressed neural development genes. …”
Publicado 2007
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48546Publicado 1989“…In vitro studies of endosomes isolated from mutant cells suggested that the acidification defect is most likely in the proton pump itself. In one mutant, this defect resulted in increased sensitivity of the electrogenic H+ pump to fluctuations in the endosomal membrane potential.…”
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48547Publicado 1993“…The in vitro ATP-dependent proSRIF processing was inhibited by inclusion of chloroquine, a weak base, CCCP, a protonophore, or by preincubating the permeabilized cells with low concentrations of N- ethylmaleimide, an inhibitor of vacuolar-type ATP-dependent proton pumps. These data suggest that: (a) proSRIF cleavage is initiated in the TGN, and (b) this reaction requires an acidic pH which is facilitated by a Golgi-associated vacuolar-type ATPase. …”
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48548por Chernova, M.N., Jiang, L., Crest, M., Hand, M., Vandorpe, D.H., Strange, K., Alper, S.L.“…Functional evaluation of chemically modified human erythrocytes has led to the proposal that amino acid residue E681 of the band 3 anion exchanger AE1 lies on the anion translocation pathway and is a proton carrier required for H(+)/SO(4) (2−) cotransport. …”
Publicado 1997
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48549Publicado 1995“…Furthermore, almost all of the Ca that is released from the SR is expected to be rapidly bound by EGTA and exchanged for protons with a 1:2 stoichiometry. Consequently, the time course of SR Ca release can be estimated by scaling the delta pH signal measured with phenol red by -beta/2. …”
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48550por Solzin, Johannes, Helbig, Annika, Van, Qui, Brown, Joel E., Hildebrand, Eilo, Weyand, Ingo, Kaupp, U. Benjamin“…Cell Biol. 5:109–117), we reexamined the role of protons in chemotaxis of sperm using kinetic measurements of the changes in pH(i) and intracellular Ca(2+) concentration. …”
Publicado 2004
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48551“…The channel may be blocked by OH(−) ions, or protons may titrate a site in the pore necessary for ion permeation. …”
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48552“…BACKGROUND: Protein-amide proton hydrogen-deuterium exchange (HDX) is used to investigate protein conformation, conformational changes and surface binding sites for other molecules. …”
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48553por Huang, Hai, Wang, Hao, Qi, Nan, Kozekova, Albena, Rizzo, Carmelo J., Stone, Michael P.“…The trans configuration of the HNE H6 and H8 protons is preferred. The presence of these cyclic hemiacetals in duplex DNA is significant as they mask the aldehyde species necessary for interstrand cross-link formation.…”
Publicado 2008
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48554“…Individual variables which predicted a good response to surgery (P<0.5); were a good response to proton pump inhibitors (PPis), volume reflux and a pH score of more than 14. …”
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48555por Draper, John, Enot, David P, Parker, David, Beckmann, Manfred, Snowdon, Stuart, Lin, Wanchang, Zubair, Hassan“…Most database interfaces support only simple queries with the default assumption that molecules either gain or lose a single proton when ionised. In reality the annotation process is confounded by the fact that many ionisation products will be not only molecular isotopes but also salt/solvent adducts and neutral loss fragments of original metabolites. …”
Publicado 2009
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48556“…An increase in T(2) relaxation rates for the Tg(6) base protons is attributed to puckering of the Tg base, accompanied by increased disorder at the Tg·G mismatch pair. …”
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48557por Kitko, Ryan D., Cleeton, Rebecca L., Armentrout, Erin I., Lee, Grace E., Noguchi, Ken, Berkmen, Melanie B., Jones, Brian D., Slonczewski, Joan L.“…Response to acid stress is a poorly understood function of external pH and of permeant acids that conduct protons into the cytoplasm. METHODS AND PRINCIPAL FINDINGS: Cytoplasmic acidification and the benzoate transcriptome were observed in Bacillus subtilis. …”
Publicado 2009
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48558por Schneider, Uffe V, Severinsen, Jette K, Géci, Imrich, Okkels, Limei M, Jøhnk, Nina, Mikkelsen, Nikolaj D, Klinge, Teena, Pedersen, Erik B, Westh, Henrik, Lisby, Gorm“…Hoogsteen based parallel triplex helix formation requires protonation of cytosines in the triplex forming strand. …”
Publicado 2010
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48559“…Dose–response analysis suggested that two protons are necessary to induce block with an apparent pK of ∼7.1. …”
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48560por Vetti, Nils, Kråkenes, Jostein, Eide, Geir E, Rørvik, Jarle, Gilhus, Nils E, Espeland, Ansgar“…METHODS: Within 13 days after a car accident, 114 consecutive acute WAD1-2 patients without prior neck injury or prior neck problems underwent upper neck high-resolution proton-weighted MRI. High-signal changes of the alar and transverse ligaments were graded 0-3. …”
Publicado 2010
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