“…The Cor-Redox peak is found to be highly symmetrical (peak-to-peak potential separation of ∼0 V tested by cyclic voltammetry (CV)) and surface-confined (Γ(Cor-Redox) = 10.1 × 10(–9) mol cm(–2)) and has proton-coupled electron-transfer (∂E°′/∂pH = −56 mV pH(–1)) character. …”
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“…Genomic and proteomic changes were accompanied by mitochondrial dysfunction, represented by significantly reduced oxygen consumption rate, ATP production, and proton leak (P < 0.05). This study suggested that EPA and DHA may alter the BAT fate of myoblasts by inhibiting mitochondrial biogenesis and activity and induce white-like adipogenesis, shifting the metabolism from lipid oxidation to synthesis.…”
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“…Measurements at higher beam intensities and with protons are planned.…”
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“…In conclusion, we successfully enriched multiple phylotypes of comammox and nitrite-oxidizing Nitrospira and revealed that the pH and concentrations of protonated N-compounds were potential niche determinants.…”
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“…For the first time, carbodiphosphorane CDP(CH(2)PPh(2))(2) (13) could be isolated upon treating its precursor [CH(dppm)(2)]Cl (12) with NaNH(2) in liquid NH(3). A protonated and a deprotonated derivative of ligand 13 were prepared, and their coordination was compared to neutral CDP ligand 13. …”
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“…Water participates in the elementary reaction in which the H atom attached on the aromatic ring shifts to the OO group, serving as a bridge that stabilizes the transition state and transports the proton. A comprehensive investigation explains the degradation mechanism of BaP initiated by (•)OH and (1)O(2) in aqueous solution.…”
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“…Morpholine is shown to decompose nGC1 by nucleophilic abstraction of the methylidene ligand; DBU, by proton abstraction from the metallacyclobutane. Decomposition was minimized at 70 °C, at which nGC1 enabled TONs of ca. 60 000 even in the presence of morpholine or DBU, vs ca. 80 000 in the absence of base. …”
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“…The effects of these diverse clustered and networked structures were disentangled here by measuring turnover rates of gas-phase ethanol dehydration to diethyl ether (DEE) on H-form zeolites as water pressure was increased to the point of intrapore condensation, causing protons to become solvated in larger clusters that subsequently become solvated by extended hydrogen-bonded water networks, according to in situ IR spectra. …”
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“…Tautomeric wobblization of the G(*)·C(*)(rWC) (relative Gibbs free energy ΔG = 0.00/relative electronic energy ΔE = 0.00 kcal·mol(−1)) (“r”—means the configuration of the base pair in reverse position; “WC”—the classic Watson-Crick configuration) and G(*t)·C(*)(H) (ΔG = −0.19/ΔE = 0.29 kcal·mol(−1)) (“H”—Hoogsteen configuration;”t” denotes the O6H hydroxyl group in the trans position) base pairs are preceded by the stages of the base pairs tautomerization by the single proton transfer (SPT). It was established that the G(*t)·C(*)(rH) (ΔG = 2.21/ΔE = 2.81 kcal·mol(−1)) base pair can be wobbled through two different pathways via the traditional one-stage mechanism through the TSs, which are tight G(+)·C(−) ion pairs, stabilized by the participation of only two intermolecular H-bonds. …”
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“…Possible pathway variants differ in their intermediate metabolites, in which electron carriers are involved, in which steps are consuming/producing ATP, and in which steps are coupled to (and to how many) proton (or its equivalent) translocations. A pathway variant is deemed feasible, under a given set of physiological and environmental conditions, only if all pathway reaction steps have nonpositive Gibbs energy changes and if all the metabolite concentrations remain within an acceptable physiological range (10(−6) to 10(−2) M). …”
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“…This study aimed to evaluate the sensitivity gain of a fast 1.6-mm isotropic MPM protocol including post-processing optimized for longitudinal clinical studies. 6 healthy volunteers (35±7 years old; 3 female) were scanned at 3T to acquire the following whole-brain MPM maps with 1.6 mm isotropic resolution: proton density (PD), magnetization transfer saturation (MT), longitudinal relaxation rate (R1), and transverse relaxation rate (R2(*)). …”
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“…Compared with the control, ZnLA treatment had no significant effect on mitochondrial membrane potential, whereas it markedly increased the mitochondrial basal OCR, nonmitochondrial respiratory capacity, and mitochondrial proton leakage and reduced spare respiratory capacity and mitochondrial reactive oxygen (ROS) production in IPEC-J2 cells. …”
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“…Doravirine is attractive for this population as it can be used in renal impairment, moderate hepatic impairment, is unaffected by timing of meals, and (unlike rilpivirine) has no interaction with proton pump inhibitors. Dolutegravir is included in NRTI-sparing regimens that HHS guidelines suggest should be considered in older PWH, especially with CKD. …”
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“…Warfarin was the most frequently reported interacting drug and the most common ADRs were gastrointestinal or cerebral hemorrhagic events. The proton pump inhibitors/warfarin, followed by platelet aggregation inhibitors/warfarin were the drug-drug combinations most frequently involved in ADRs caused by DDIs. …”
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“…In this system phosphate is transported as a metal-phosphate complex in simport with protons. Expression of pitH2, but not that of pitH1 in Streptomyces coelicolor, is regulated by PhoP. …”
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“…Proton magnetic resonance spectroscopy ((1)H-MRS) is a noninvasive imaging technique that measures the concentration of metabolites in defined areas of the human brain in vivo. …”
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“…MRI-derived biomarkers proton density fat fraction (PDFF) and iron-corrected T1 mapping (cT1) are gaining traction as emerging alternatives to biopsy for NASH. …”
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“…However, compared to the wildtype (WT) cells, exposure to either tBHP or ROT enhanced the production of ROS, ECAR, and the proton (H(+)) production rate (PPR) from glycolysis, as well as promoted apoptotic cell death in VDAC1(−/−) H9c2 cells. …”
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“…Additionally, 41 patients and 41 healthy controls underwent proton magnetic resonance spectroscopy ((1)H-MRS) to obtain ratios of N-acetyl aspartate to creatine (NAA/Cr) and choline-containing compounds to creatine (Cho/Cr) in the lenticular nucleus (LN) of basal ganglia (BG). …”
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