Preclinical Studies of the Potent and Selective Nicotinic α4β2 Receptor Ligand VMY-2-95

por Kong, Hyesik, Song, Jun-ke, Yenugonda, Venkata Mahidhar, Zhang, Li, Shuo, Tian, Cheema, Amrita K., Kong, Yali, Du, Guan-hua, Brown, Milton L.
Publicado 2014

Selective Activation of M(4) Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

por Bubser, Michael, Bridges, Thomas M., Dencker, Ditte, Gould, Robert W., Grannan, Michael, Noetzel, Meredith J., Lamsal, Atin, Niswender, Colleen M., Daniels, J. Scott, Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Byers, Frank W., Wess, Jürgen, Duggan, Mark E., Dunlop, John, Wood, Michael W., Brandon, Nicholas J., Wood, Michael R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Publicado 2014

Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine

por Szulik, Marta W., Pallan, Pradeep S., Nocek, Boguslaw, Voehler, Markus, Banerjee, Surajit, Brooks, Sonja, Joachimiak, Andrzej, Egli, Martin, Eichman, Brandt F., Stone, Michael P.
Publicado 2015

DNA Sequence Modulates Geometrical Isomerism of the trans-8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B(1) Adduct

por Li, Liang, Brown, Kyle L., Ma, Ruidan, Stone, Michael P.
Publicado 2015

Perspectives on Electrostatics and Conformational Motions in Enzyme Catalysis

por Hanoian, Philip, Liu, C. Tony, Hammes-Schiffer, Sharon, Benkovic, Stephen
Publicado 2015

One-Step (18)F Labeling of Non-Peptidic Bivalent Integrin α(v)β(3) Antagonist for Cancer Imaging

por Wang, Weiwei, Liu, Zhiyi, Li, Zheng
Publicado 2014

Theoretical Investigation of the Electronic Structure of Fe(II) Complexes at Spin-State Transitions

por Pápai, Mátyás, Vankó, György, de Graaf, Coen, Rozgonyi, Tamás
Publicado 2012

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

por Roy, Saktimayee M., Grum-Tokars, Valerie L., Schavocky, James P., Saeed, Faisal, Staniszewski, Agnieszka, Teich, Andrew F., Arancio, Ottavio, Bachstetter, Adam D., Webster, Scott J., Van Eldik, Linda J., Minasov, George, Anderson, Wayne F., Pelletier, Jeffrey C., Watterson, D. Martin
Publicado 2015

Ziram and Sodium N,N-Dimethyldithiocarbamate Inhibit Ubiquitin Activation through Intracellular Metal Transport and Increased Oxidative Stress in HEK293 Cells

por Dennis, Kathleen E., Valentine, William M.
Publicado 2015

PdO Doping Tunes Band-Gap Energy Levels as Well as Oxidative Stress Responses to a Co(3)O(4)p-Type Semiconductor in Cells and the Lung

por Zhang, Haiyuan, Pokhrel, Suman, Ji, Zhaoxia, Meng, Huan, Wang, Xiang, Lin, Sijie, Chang, Chong Hyun, Li, Linjiang, Li, Ruibin, Sun, Bingbing, Wang, Meiying, Liao, Yu-Pei, Liu, Rong, Xia, Tian, Mädler, Lutz, Nel, André E.
Publicado 2014

Hybrid Steered Molecular Dynamics Approach to Computing Absolute Binding Free Energy of Ligand–Protein Complexes: A Brute Force Approach That Is Fast and Accurate

por Chen, Liao Y.
Publicado 2015

Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice

por Meng, Huan, Wang, Meiying, Liu, Huiyu, Liu, Xiangsheng, Situ, Allen, Wu, Bobby, Ji, Zhaoxia, Chang, Chong Hyun, Nel, Andre E.
Publicado 2015

Spectroscopic Studies Reveal That the Heme Regulatory Motifs of Heme Oxygenase-2 Are Dynamically Disordered and Exhibit Redox-Dependent Interaction with Heme

por Bagai, Ireena, Sarangi, Ritimukta, Fleischhacker, Angela S., Sharma, Ajay, Hoffman, Brian M., Zuiderweg, Erik R. P., Ragsdale, Stephen W.
Publicado 2015

Amine Functionalization via Oxidative Photoredox Catalysis: Methodology Development and Complex Molecule Synthesis

por Beatty, Joel W., Stephenson, Corey R. J.
Publicado 2015

How To Deal with Multiple Binding Poses in Alchemical Relative Protein–Ligand Binding Free Energy Calculations

por Kaus, Joseph W., Harder, Edward, Lin, Teng, Abel, Robert, McCammon, J. Andrew, Wang, Lingle
Publicado 2015

Methods and Mechanisms for Cross-Electrophile Coupling of Csp(2) Halides with Alkyl Electrophiles

por Weix, Daniel J.
Publicado 2015

Characterization of the Dynamics in the Protonic Conductor CsH(2)PO(4) by (17)O Solid-State NMR Spectroscopy and First-Principles Calculations: Correlating Phosphate and Protonic M...

por Kim, Gunwoo, Griffin, John M., Blanc, Frédéric, Haile, Sossina M., Grey, Clare P.
Publicado 2015

A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection

por Choi, Jin Huk, Jonsson-Schmunk, Kristina, Qiu, Xiangguo, Shedlock, Devon J., Strong, Jim, Xu, Jason X., Michie, Kelly L., Audet, Jonathan, Fernando, Lisa, Myers, Mark J., Weiner, David, Bajrovic, Irnela, Tran, Lilian Q., Wong, Gary, Bello, Alexander, Kobinger, Gary P., Schafer, Stephen C., Croyle, Maria A.
Publicado 2014

Joint Experimental and Computational (17)O and (1)H Solid State NMR Study of Ba(2)In(2)O(4)(OH)(2) Structure and Dynamics

por Dervişoğlu, Rıza, Middlemiss, Derek S., Blanc, Frédéric, Lee, Yueh-Lin, Morgan, Dane, Grey, Clare P.
Publicado 2015

Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron–Sulfur Enzyme in Pathogenic Bacteria

por Blachly, Patrick G., Sandala, Gregory M., Giammona, Debra Ann, Bashford, Donald, McCammon, J. Andrew, Noodleman, Louis
Publicado 2015