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  1. 3201
    “…RESULTS: Building from our well-characterized C57Bl/6N mouse model employing daily gestational UFP exposure from gestational day (GD) 0.5–13.5, we carried out a pilot study wherein pregnant dams were subsequently infected with Influenza A/Puerto Rico/8/1934 (PR8) on GD14.5. Findings indicate that PR8 infection caused decreased weight gain in filtered air (FA) and UFP-exposed groups. …”
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    Maternal exposure to ultrafine particles enhances influenza infection during pregnancy
  2. 3202
    por Zhu, David T.
    Publicado 2023
    “…RESULTS: Xylazine emerged as an adulterant in Puerto Rico in 2001, likely diverted from veterinary supplies. …”
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    Public health impact and harm reduction implications of xylazine-involved overdoses: a narrative review
  3. 3203
    “…The study was conducted in the US and Puerto Rico. Immune persistence and response were assessed with a serum bactericidal assay using human complement (hSBA). …”
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    1157. Immune Persistence and Booster Response of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) 5 Years After Primary Vaccination of Adults ≥59 Years of Age
  4. 3204
    “…RESULTS: When tested in BALB/c mice supplemented with physiological levels of human IgG (IVIG) and infected with 10xLD50 of influenza A virus (H1N1, A/Puerto Rico/8/1934), EV21 elicited excellent antiviral activity. …”
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    2147. Design of a Ligand-Targeted Immunotherapy for Treatment of Influenza Virus Infections
  5. 3205
    “…Using the substrate Bz-Val-Gly-Arg-p-nitroanilide or in zymograms, the intensities of proteolysis increased in homogenates from both mouse strains with time post infection (p.i.) with the mouse-adapted influenza virus A/Puerto Rico/8/34 (H1N1; PR8). In zymograms at day 7 p.i., proteolytic bands were stronger and numerous in lung homogenates from DBA/2J than C57Bl/6J mice. …”
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    Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection
  6. 3206
    “…METHODS: This study included 1,486 patients who enrolled between January, 2000 and December, 2010 in an HIV-cohort in Bayamón, Puerto Rico. Data were collected through personal interviews and medical record abstractions. …”
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    Anemia in a cohort of HIV-infected Hispanics: prevalence, associated factors and impact on one-year mortality
  7. 3207
    “…Replication was conducted in the participants of the Boston Puerto Rican Health Study (BPRHS) without diabetes (n = 716). …”
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    Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits
  8. 3208
    “…In January 2014, we sent birth defects surveillance programs in each state, District of Columbia, Puerto Rico, Centers for Disease Control and Prevention (CDC), and the U.S. …”
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    Development and implementation of the first national data quality standards for population-based birth defects surveillance programs in the United States
  9. 3209
    “…METHODS: In 2015, two survey research projects were developed and piloted in Puerto Rico and pre-tested in Costa Rica to collect face-to-face data, get formative evaluation feedback, and to test the feasibility of an offline mobile data collection process. …”
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    Development and Implementation of Culturally Tailored Offline Mobile Health Surveys
  10. 3210
    “…We evaluated such associations among participants of the Zika virus Persistence (ZiPer) study in Puerto Rico. METHODS: Patients presenting for care with Zika-like illness and ZIKV RNA detected by RT-PCR in serum or urine (index cases) were offered study participation. …”
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    Risk Factors Associated with Persistence of Zika Virus Nucleic Acid in Serum and Semen
  11. 3211
    “…METHODS: Population-based cohort studies in urban sites in Cuba, Dominican Republic Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China. …”
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    Leg length, skull circumference, and the incidence of dementia in Latin America and China: A 10/66 population-based cohort study
  12. 3212
    “…Additionally, this virus induced high-titer neutralizing antibodies against the WT WSN, A/Puerto Rico/8/1934 (PR8), or A/California/04/2009 (CA04) viruses and provided 100% protection against the WT WSN virus. …”
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    A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus
  13. 3213
    “…METHODS: The Surveillance Monitoring for ART Toxicities (SMARTT) study is an ongoing NICHD-funded observational multi-centered cohort study (United States and Puerto Rico) of growth and development of HEU children that commenced in 2007. …”
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    114. Birth Prevalence of Congenital Cytomegalovirus Infection and Language, Hearing, and Developmental Outcomes in a Cohort of HIV-Exposed, Uninfected Preschool Children
  14. 3214
    “…METHODS: Among a subset of HEU children in the multicenter (United States and Puerto Rico) observational Surveillance Monitoring for ART Toxicities (SMARTT) Cohort study, we enrolled neonates (≥36 weeks gestational age) of HIV+ mothers who took TDF for ≥8 weeks in the third trimester (TDF+) or no TDF in pregnancy (TDF-). …”
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    2261. Phosphaturia in HIV-Exposed Uninfected Neonates Associated With Maternal Use of Tenofovir Disoproxil Fumarate in Late Pregnancy
  15. 3215
    “…We analyzed these five variants in 2492 diabetes cases and 5236 controls from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), which includes U.S. participants from six diverse background groups (Mainland groups: Mexican, Central American, and South American; and Caribbean groups: Puerto Rican, Cuban, and Dominican). We estimated the SNP-diabetes association in the six groups and in the combined sample. …”
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    Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
  16. 3216
    “…METHODS: At research sites in ZIKV endemic regions of Brazil (4 sites), Colombia, Guatemala, Nicaragua, Puerto Rico (2 sites), and Peru, up to 10,000 pregnant women will be recruited and consented in the first and early second trimesters of pregnancy and then followed through delivery up to 6 weeks post-partum; their infants will be followed until at least 1 year of age. …”
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    International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): study protocol
  17. 3217
    “…This pilot study sample included 40 participants from the six main Hispanic/Latino background groups in the United States, namely Dominican, Cuban, Puerto Rican, Mexican, Central American, and South American, and were grouped by Caribbean or mainland origin. …”
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    The Association between Cardiovascular Disease Risk Factors and 25-Hydroxivitamin D and Related Analytes among Hispanic/Latino Adults: A Pilot Study
  18. 3218
    “…METHODS: We inoculated 5 pregnant rhesus macaques with a Puerto Rican isolate of ZIKV (ZIKV-PRVABC59) during the first trimester, monitored infection with plasma viral RNA (vRNA) loads, and evaluated infants for birth defects and neurodevelopmental deficits during their first week of life. …”
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    2784. Increased Frontal Lobe Volume and Density in Macaques Exposed to Zika Virus In Utero
  19. 3219
    “…In order to characterize the strain-specific effects of IAV NS1 on human DC activation, we infected human DCs with a panel of recombinant viruses with the same backbone (A/Puerto Rico/08/1934) expressing different NS1 proteins from human and avian origin. …”
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    Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1
  20. 3220
    “…Among 218 variant-positive individuals, 112 (51.4%) harbored known founder variants: 80 had AJ founder variants (BRCA1 c.5266dupC and c.68_69delAG, and BRCA2 c.5946delT), 8 had a Puerto Rican founder variant (BRCA2 c.3922G>T), and 24 had one of 19 other founder variants. …”
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    Exome sequencing reveals a high prevalence of BRCA1 and BRCA2 founder variants in a diverse population-based biobank
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