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  1. 59501
    “…Este conjunto de características puede contribuir a la habilidad de las especies para llevar a cabo la transición de naturalizada a invasora a lo largo de una amplia cobertura de contextos ambientales y regímenes de perturbación. Nuestros hallazgos ayudarán en la mejora de los protocolos de ERH, y abogamos por la inclusión de las características cuantitativas, en particular la AEH, en los esquemas de ERH.…”
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    Trait differences between naturalized and invasive plant species independent of residence time and phylogeny
  2. 59502
    “…Our patient’s clinical course is confounded by the incorporation of idelalisib while being further complicated by the complexity of HT and the mechanisms in which first-line chemotherapy regimens affect double-hit lymphoma.…”
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    Transformation of Follicular Lymphoma to a High-Grade B-Cell Lymphoma With MYC and BCL2 Translocations and Overlapping Features of Burkitt Lymphoma and Acute Lymphoblastic Leukemia: A Case Report and Literature Review
  3. 59503
    “…Further research may help evaluate percutaneous drainage of the pericardium under local anaesthesia, the timing of pericardiectomy in tuberculous constrictive pericarditis, and new antibiotic regimens. 2 April 2019 Up to date All studies incorporated from most recent search All eligible published studies found in the last search (27 Mar, 2017) were included and one ongoing study was identified (see 'Characteristics of ongoing studies' section)…”
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    Interventions for treating tuberculous pericarditis
  4. 59504
    por Harausz, Elizabeth P., Garcia-Prats, Anthony J., Law, Stephanie, Schaaf, H. Simon, Kredo, Tamara, Seddon, James A., Menzies, Dick, Turkova, Anna, Achar, Jay, Amanullah, Farhana, Barry, Pennan, Becerra, Mercedes, Chan, Edward D., Chan, Pei Chun, Ioana Chiotan, Domnica, Crossa, Aldo, Drobac, Peter C., Fairlie, Lee, Falzon, Dennis, Flood, Jennifer, Gegia, Medea, Hicks, Robert M., Isaakidis, Petros, Kadri, SM, Kampmann, Beate, Madhi, Shabir A., Marais, Else, Mariandyshev, Andrei, Méndez-Echevarría, Ana, Moore, Brittany Kathryn, Nargiza, Parpieva, Ozere, Iveta, Padayatchi, Nesri, ur-Rehman, Saleem-, Rybak, Natasha, Santiago-Garcia, Begoña, Shah, N. Sarita, Sharma, Sangeeta, Shim, Tae Sun, Skrahina, Alena, Soriano-Arandes, Antoni, van den Boom, Martin, van der Werf, Marieke J., van der Werf, Tjip S., Williams, Bhanu, Yablokova, Elena, Yim, Jae-Joon, Furin, Jennifer, Hesseling, Anneke C.
    Publicado 2018
    “…Limitations of this study include the difficulty of estimating the treatment effects of individual drugs within multidrug regimens, only observational cohort studies were available for inclusion, and treatment decisions were based on the clinician’s perception of illness, with resulting potential for bias. …”
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    Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis
  5. 59505
    “…However, limited data exist on how IPTp regimens impact malaria risk during infancy. We conducted a double-blinded randomized controlled trial (RCT) to test the hypothesis that children born to mothers given IPTp-DP would have a lower incidence of malaria during infancy compared to children born to mothers who received IPTp-SP. …”
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    Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial
  6. 59506
    “…Future research should focus on interventions to simplify drug regimens and administration for senior patients. 5. …”
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    The Impact of Inflammatory Bowel Disease in Canada 2018: IBD in Seniors
  7. 59507
    “…Men aged 18 years or older with progressing metastatic castration-resistant prostate cancer previously treated with one or two taxane chemotherapy regimens and with an Eastern Cooperative Oncology Group performance status of 2 or less had tumour biopsies tested with targeted sequencing. …”
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    Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial
  8. 59508
    “…This study also demonstrates that for comparison of different IVF treatment regimens, the cumulative outcome, including transfers of fresh and frozen-thawed embryos, is to be preferred instead of analysis of fresh embryo transfers only. …”
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    Reduced oxygen concentration during human IVF culture improves embryo utilization and cumulative pregnancy rates per cycle
  9. 59509
    Publicado 2019
    “…All of them were treated with R-CHOP (32 cases, rituximab combined with CHOP), dose-intensive regimens (DA-EPOCH, Hyper CVAD/MA or ESHAP) combined with or without rituximab (25 cases), and consolidated with up-front auto-HSCT (33 cases), respectively. …”
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    诱导化疗联合或不联合自体造血干细胞移植治疗年龄≤60岁初治中高危/高危弥漫大B细胞淋巴瘤的比较研究
  10. 59510
    “…CONCLUSIONS AND RELEVANCE: Baseline plasma MMP and TIMP levels may be correlates of risk and prognostic biomarkers for treatment failure, relapse, and death in individuals with PTB and merit further evaluation as predictive biomarkers for stratification of patients to shortened or intensified treatment regimens.…”
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    Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis
  11. 59511
    “…IMPORTANCE: One of the most recent treatment regimens used for hormone receptor (HR)–positive, ERBB2 (formerly HER2)–negative metastatic breast cancer is treatment with the cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors and endocrine therapy (ET). …”
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    Association of Cyclin-Dependent Kinases 4 and 6 Inhibitors With Survival in Patients With Hormone Receptor–Positive Metastatic Breast Cancer: A Systematic Review and Meta-analysis
  12. 59512
    “…For patients with cancer, NICE recommend delivering systemic anti-cancer treatment in different and less immunosuppressive regimens, different locations (ideally at home) or via another (less invasive and/or less resource intensive) route of administration where possible.(8)(9) The objective of this analysis is to explore the impact of switching patients from intravenous (IV) treatments requiring hospital administrations to subcutaneous (SC) or oral alternatives which can be administered at home or in an outpatient setting which reduces the patient's potential exposure to COVID-19. …”
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    Delivering Systemic Anti-Cancer Treatment Via Another Route of Administration As an Option to Reduce Exposure to COVID-19 in Patients with Multiple Myeloma in the UK
  13. 59513
    “…The calculators were easy to use and applicable to both short- and long-course radiotherapy regimens, and they may be used to inform surveillance strategies and facilitate future clinical trials and statistical power calculations.…”
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    Development and Assessment of a Clinical Calculator for Estimating the Likelihood of Recurrence and Survival Among Patients With Locally Advanced Rectal Cancer Treated With Chemotherapy, Radiotherapy, and Surgery
  14. 59514
    “…METHODS: In this multicentre, prospective, case-control study (VIP), we recruited adults with IBD treated with one of six different immunosuppressive treatment regimens (thiopurines, infliximab, a thiopurine plus infliximab, ustekinumab, vedolizumab, or tofacitinib) and healthy control participants from nine centres in the UK. …”
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    COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study
  15. 59515
    “…STUDY DESIGN, SIZE, DURATION: This study includes a cohort of 160 healthy young Danish women using three different contraceptive regimens: non-hormonal methods (n = 54), combined oral contraceptive (COC, n = 52) or levonorgestrel intrauterine system (LNG-IUS, n = 54). …”
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    The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle
  16. 59516
    “…This study sought to investigate patient demographics associated with poor follow-up after initiation of nonoperative management regimens for anterior shoulder instability. We hypothesized that significant disparities would be observed with nonoperative follow-up rates. …”
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    Poster 156: Investigating Disparity in Follow-Up Rates of Non-Operative Treatment for Anterior Shoulder Instability
  17. 59517
    “…Cohort A1 included patients with postchemotherapy mCRPC (1–2 prior taxane-based regimens) and ≤2 prior novel hormonal therapies (eg, abiraterone, enzalutamide, apalutamide); cohort A2 included patients with chemotherapy-naïve mCRPC and prior novel hormonal therapy. …”
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    Nivolumab plus rucaparib for metastatic castration-resistant prostate cancer: results from the phase 2 CheckMate 9KD trial
  18. 59518
    “…The immunosuppressed patients with IBD had an established diagnosis of Crohn's disease, ulcerative colitis, or unclassified IBD using standard definitions of IBD, and were receiving established treatment with one of six immunosuppressive regimens for at least 12 weeks at the time of first dose of SARS-CoV-2 vaccination. …”
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    COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control study
  19. 59519
    “…Of those, 74 were treated with subsequent platinum regimens, with the following results: ORR of 41.9%, median PFS (mPFS) of 6.6 months (95% CI 6–9.2), and median OS (mOS) of 20.6 months (95% CI 13.6–28.9). …”
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    Multicenter Real-World Data of Subsequent Chemotherapy after Progression to PARP Inhibitors in a Maintenance Relapse Setting
  20. 59520
    “…BACKGROUND: COVID-19 vaccines provide protection against symptomatic infection that might require medical attention and against severe outcomes; however, there is a paucity of evidence regarding the effectiveness of the BNT162b2 and CoronaVac vaccines and their booster regimens against asymptomatic or mild omicron infections in the community. …”
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    Effectiveness of BNT162b2 and CoronaVac COVID-19 vaccination against asymptomatic and symptomatic infection of SARS-CoV-2 omicron BA.2 in Hong Kong: a prospective cohort study
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