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  1. 261
    “…BACKGROUND: Rap proteins belong to the Ras family of small G-proteins. …”
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    GxcC connects Rap and Rac signaling during Dictyostelium development
  2. 262
    “…We tested a hypothesis that Rho down-regulation and barrier recovery of agonist-stimulated ECs is mediated by the Ras family GTPase Rap1. Thrombin-induced EC permeability driven by rapid activation of the Rho GTPase pathway was followed by Src kinase–dependent phosphorylation of the Rap1-specific guanine nucleotide exchange factor (GEF) C3G, activation of Rap1, and initiation of EC barrier recovery. …”
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    Rap-afadin axis in control of Rho signaling and endothelial barrier recovery
  3. 263
    “…Receptor Associated Protein 80 (RAP80) is a member of RAP80-BRCA1-CCDC98 complex family and helps in its recruitment to the DNA damage site for effective homologous recombination repair. …”
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    Structural and Functional Implication of RAP80 ΔGlu81 Mutation
  4. 264
    “…MIA/CD-RAP is a small, secreted protein involved in cartilage differentiation and melanoma progression. …”
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    YBX1 Is a Modulator of MIA/CD-RAP-Dependent Chondrogenesis
  5. 265
    “…To understand how Rap1 affects key functions of TRF2, we investigated full-length Rap1 binding to TRF2 and Rap1–TRF2 complex interactions with double-stranded DNA by quantitative biochemical approaches. …”
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    Human Rap1 modulates TRF2 attraction to telomeric DNA
  6. 266
    “…Homozygous mutations of the Cyclin-dependent kinase-5 regulatory subunit-associated protein 2 gene CDK5RAP2 are one genetic cause of MCPH. To further characterize the pathomechanism underlying MCPH, we generated a conditional Cdk5rap2 LoxP/hCMV Cre mutant mouse. …”
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    Novel Alternative Splice Variants of Mouse Cdk5rap2
  7. 267
    “…PLCε-deficient arterial endothelial cells also exhibited decreased Rap1-GTP levels, which could be restored by activation of the Rap1 GEF, Epac, to rescue the increase in monolayer leak. …”
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    Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier
  8. 268
    “…There are two other methyltransferases RapI and RapQ which provide methyl substituents of rapamycin. …”
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    Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase
  9. 269
    “…However, the cell-intrinsic functions of IL1RAP in AML cells are largely unknown. Here, we show that targeting of IL1RAP via RNA interference, genetic deletion, or antibodies inhibits AML pathogenesis in vitro and in vivo, without perturbing healthy hematopoietic function or viability. …”
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    IL1RAP potentiates multiple oncogenic signaling pathways in AML
  10. 270
    “…The aim of the present study was to investigate the possible implication of a cAMP/Epac/Rap1 pathway in mouse oocytes and embryos. Reverse transcription polymerase chain reaction and immunohistochemistry assays demonstrated the expression of Epac and Rap1 in oocytes and embryos at different stages. …”
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    Dynamic expression of Epac and Rap1 in mouse oocytes and preimplantation embryos
  11. 271
    “…Here we report that the small GTPase Rap1, through activation by PDZ-GEF, regulates border cell collective migration. …”
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    Rap1 GTPase promotes coordinated collective cell migration in vivo
  12. 272
    “…Moreover, we show that Rap1 binding opens chromatin fiber structure by inhibiting inter-nucleosome contacts. …”
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    Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor
  13. 273
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    RAP3DF - One shoot 3D face dataset
  14. 274
    “…Endothelial deletion of the two highly homologous Rap1 isoforms, Rap1A and Rap1B, leads to endothelial dysfunction ex vivo and hypertension in vivo. …”
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    Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium
  15. 275
    “…The miscibility of a fresh binder and a RAP binder still has not been fully recognised. …”
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    Homogeneity and Viscoelastic Behaviour of Bitumen Film in Asphalt Mixtures Containing RAP
  16. 276
    “…The RAP (RNA-binding domain abundant in Apicomplexans) protein family has been identified in various organisms. …”
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    Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum
  17. 277
    “…Nephrin signals from the slit diaphragm to the actin cytoskeleton and integrin β1 at focal adhesions by recruiting Crk family proteins, which can interact with the Rap guanine nucleotide exchange factor 1 C3G. As Rap1 activity affects focal adhesion formation, we hypothesize that nephrin signals via Rap1 to integrin β. …”
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    Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity
  18. 278
    “…Here, we report that activation of hepatocyte Rap1a suppresses gluconeogenic gene expression and glucose production, whereas Rap1a silencing stimulates them. …”
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
  19. 279
    “…The conserved Rap1 protein is part of the shelterin complex that plays critical roles in chromosome end protection and telomere length regulation. …”
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    Rap1 prevents fusions between long telomeres in fission yeast
  20. 280
    “…Altogether, these data reveal a close relationship among HPV infection, alternative splicing and tumor immune evasion, and also suggests that the SRSF10-mIL1RAP-CD47 axis could be an attractive therapeutic target for the treatment of cervical cancer.…”
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    SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis
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