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  1. 461
    por Takala, Heikki, Ylänne, Jari
    Publicado 2012
    “…The Rap1-GTP interacting adapter protein (RIAM) is an important protein in Rap1-mediated integrin activation. …”
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    Binding Properties and Stability of the Ras-Association Domain of Rap1-GTP Interacting Adapter Molecule (RIAM)
  2. 462
    por Jossin, Yves
    Publicado 2011
    “…The activation of Rap1 is triggered by Reelin, an extracellular protein known for its role in the organization of the cortex into layers of neurons. …”
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    Polarization of migrating cortical neurons by Rap1 and N-cadherin: Revisiting the model for the Reelin signaling pathway
  3. 463
    “…Here, we show that CDK5RAP1 is a radical SAM enzyme, which postsynthetically converts the RNA modification N6-isopentenyladenosine (i(6)A) into 2-methylthio-N6-isopentenyladenosine (ms(2)i(6)A). …”
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    The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
  4. 464
    “…CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. …”
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    CDK5RAP3 Is a Novel Repressor of p14(ARF) in Hepatocellular Carcinoma Cells
  5. 465
    “…The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter molecule (RIAM). …”
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    Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
  6. 466
    “…Several Rap1 effectors have been described to mediate the cellular effects of Rap1 in a context-dependent manner. …”
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    KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression
  7. 467
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    Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes
  8. 468
    “…Furthermore, we present the crystal structure of RapI. Comparison of the RapJ-PhrC, RapI, RapH-Spo0F, and RapF-ComA(C) crystal structures reveals the mechanistic basis of Phr activity. …”
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    Conformational Change-Induced Repeat Domain Expansion Regulates Rap Phosphatase Quorum-Sensing Signal Receptors
  9. 469
    “…We have previously shown that silencing BES-linked VSGs in BF cells depends on TbRAP1. We now show that TbRAP1 silences both BES-linked and mVSGs at both BF and PF stages. …”
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    Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes
  10. 470
    “…Circumferential actin bundles (CAB) promote formation of linear adherens junctions (AJs) and tightening of EC junctions, whereas formation of radial stress fibers (RSF) connected to punctate AJs occurs during junction remodeling. The small GTPase Rap1 induces CAB formation to potentiate EC junctions; however, the mechanism underlying Rap1-induced CAB formation remains unknown. …”
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    Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization
  11. 471
    “…An EST sequence, designated JnRAP2-like, was isolated from tissue at the heartwood/sapwood transition zone (TZ) in black walnut (Juglans nigra L). …”
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    Roles of JnRAP2.6-like from the Transition Zone of Black Walnut in Hormone Signaling
  12. 472
    por Berruti, Giovanna, Paiardi, Chiara
    Publicado 2014
    “…In this review, we propose a model by which the small GTPase Rap1 could regulate aES assembly/remodelling. The characterization of key players in the dynamic of aES, such as Rap1, could open new possibility to develop prognostic, diagnostic, and therapeutic approaches for male patients under treatment for infertility as well as it could lead to the identification of new target for male contraception.…”
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    The Dynamic of the Apical Ectoplasmic Specialization between Spermatids and Sertoli Cells: The Case of the Small GTPase Rap1
  13. 473
    “…The cascade bifurcates into a Rab3-GTP-driven limb that assembles the fusion machinery and a Rap-GTP-driven limb that mobilizes internal calcium. …”
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    Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosis
  14. 474
    “…Here we report that the specific upregulation of the Rap1 guanine nucleotide exchange factor, RapGEF2, in migrating neurons corresponds to the timing of this polarity transition. …”
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    Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex
  15. 475
    por Feldmann, Erik A., Galletto, Roberto
    Publicado 2014
    “…In this work, we focus on the interaction of the DNA-binding domain of Rap1 (Rap1(DBD)) with double-stranded DNA substrates. …”
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    The DNA-Binding Domain of Yeast Rap1 Interacts with Double-Stranded DNA in Multiple Binding Modes
  16. 476
    “…The Rap G protein signal regulates Notch activation in early thymic progenitor cells, and deregulated Rap activation (Rap(high)) results in the development of Notch-dependent T-cell acute lymphoblastic leukemia (T-ALL). …”
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    Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia
  17. 477
    “…The ability to cleave Ras and Rap1 is shared by DUF5(Vv) homologues found in other bacteria. …”
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    Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain
  18. 478
    “…DSBs elicit a signaling cascade involving the E3 ubiquitin ligases RNF8/RNF168 and the ubiquitin-dependent assembly of the BRCA1-Abraxas-RAP80-MERIT40 complex. The association of BRCA1 with ubiquitin conjugates through RAP80 is known to be inhibitory to DSB repair by homologous recombination (HR). …”
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    The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80
  19. 479
    “…We have previously shown that human CDK5RAP2 exists as a full-length form (hCDK5RAP2) or an alternatively spliced variant form (hCDK5RAP2-V1) that is lacking exon 32. …”
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    Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2
  20. 480
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    The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80
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