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  1. 2141
    “…Here, we reviewed our recent efforts to develop a new library of non-rationally produced AMPs that relies on bacterial genome inherent diversity and compared it with rationally designed libraries. …”
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    Design, Screening, and Testing of Non-Rational Peptide Libraries with Antimicrobial Activity: In Silico and Experimental Approaches
  2. 2142
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    Scientific hypothesis and rational pharmacological for the use of sacubitril/valsartan in cardiac damage caused by COVID-19
  3. 2143
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    Rational Design of Multi‐Color‐Emissive Carbon Dots in a Single Reaction System by Hydrothermal
  4. 2144
    “…Here, we profile the expression dynamics of 8269 rationally designed, IPTG-inducible promoters that collectively explore the individual and combinatorial effects of RNA polymerase and LacI repressor binding site strengths. …”
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    Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
  5. 2145
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    Rational surgical neck management in total laryngectomy for advanced stage laryngeal squamous cell carcinomas
  6. 2146
    “…This paper offers a parsimonious, rational-choice model to study the effect of pre-existing inequalities on the transmission of COVID-19. …”
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    A rational-choice model of Covid-19 transmission with endogenous quarantining and two-sided prevention()
  7. 2147
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    Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection
  8. 2148
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    Galaxy and MEAN Stack to Create a User-Friendly Workflow for the Rational Optimization of Cancer Chemotherapy
  9. 2149
    “…Here, to pursue this approach, we rationally designed a panel of six bicyclic peptides targeting various epitopes along the sequence of Aβ42 to scan its most amyloidogenic region (residues 13–42). …”
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    Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures
  10. 2150
    “…BACKGROUND: Healthcare rationing can be defined as withholding beneficial care for cost reasons. …”
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    Hidden bedside rationing in the Netherlands: a cross-sectional survey among physicians in internal medicine
  11. 2151
    “…However, it is well reported that MSG is associated with a number of neurological diseases, and in turn, neurological diseases are associated with protein aggregation. This study rationalized the role of MSG in protein aggregation using different biophysical techniques such as absorption, far-UV CD, DLS, and ITC. …”
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    Rationalizing the Role of Monosodium Glutamate in the Protein Aggregation Through Biophysical Approaches: Potential Impact on Neurodegeneration
  12. 2152
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    Is a Rational Politics of Disaster Possible? Making Useful Decisions for Others in an Experimental Disaster Game
  13. 2153
    por Szaflarska-Popławska, Anna
    Publicado 2021
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    Wait-and-See Approach or Gluten-Free Diet Administration—The Rational Management of Potential Coeliac Disease
  14. 2154
    “…Rationally designing drugs that last longer in the face of biological evolution is a critical objective of drug discovery. …”
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    Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design
  15. 2155
    “…[Image: see text] The experimental data collected over the past 15 years on the interaction of decavanadate(V) (V(10)O(28)(6–); V(10)), a polyoxometalate (POM) with promising anticancer and antibacterial action, with G-actin, were rationalized by using several computational approaches (docking, density functional theory (DFT), and molecular dynamics (MD)). …”
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    Rationalizing the Decavanadate(V) and Oxidovanadium(IV) Binding to G-Actin and the Competition with Decaniobate(V) and ATP
  16. 2156
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    Extension of a de novo TIM barrel with a rationally designed secondary structure element
  17. 2157
    “…Unilateral medial prefrontal lesions reduced these biases, leading to more rational decisions. Bilateral vmPFC lesions resulted in more strategic betting, again with less bias from the previous trial, paradoxically improving performance overall. …”
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    Reduced decision bias and more rational decision making following ventromedial prefrontal cortex damage
  18. 2158
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    Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe
  19. 2159
    “…To address this, we apply a rational protein engineering approach to create a new CRISPRa platform that is highly modular to allow for easy customization and has increased targeting flexibility through harnessing engineered Cas proteins. …”
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    Rational engineering of a modular bacterial CRISPR–Cas activation platform with expanded target range
  20. 2160
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    Rational construction of a reversible arylazo-based NIR probe for cycling hypoxia imaging in vivo
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