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  1. 2161
    “…GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. …”
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    Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
  2. 2162
    “…Furthermore, having such rationally well-defined catalytic sites coupled with in situ Raman and infrared spectroelectrochemical measurements enabled the deduction of the reaction mechanism in which co-adsorbed *OH functions as a proton acceptor in the alcohol oxidation step and carries implications for catalyst design for heterogeneous electrosynthetic reactions en route to the electrification of the chemical industry.…”
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    Rational incorporation of defects within metal–organic frameworks generates highly active electrocatalytic sites
  3. 2163
    “…The follow-up assessment indicated that the efficacy of rational emotive career education was sustained overtime. …”
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    Irrational career beliefs in agricultural education students, demographics, impacts, and rational career education intervention
  4. 2164
    “…BACKGROUND: Rational emotive education (REE) program aims to improve the behavioral and mental health of students. …”
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    Rational emotive education for reducing stress of undergraduate students of religious education program: An experimental study
  5. 2165
    “…Bounded rationality is an important consideration stemming from the fact that agents often have limits on their processing abilities, making the assumption of perfect rationality inapplicable to many real tasks. …”
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    A Maximum Entropy Model of Bounded Rational Decision-Making with Prior Beliefs and Market Feedback
  6. 2166
    “…Rational design and economic fabrication are essential to develop carbonic electrode materials with optimized porosity for high-performance supercapacitors. …”
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    Self-Template Synthesis of Nitrogen-Doped Hollow Carbon Nanospheres with Rational Mesoporosity for Efficient Supercapacitors
  7. 2167
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    “Cyclopropylidene Effect” in the 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Cyclopropanes: A Computational Rationalization
  8. 2168
    “…BACKGROUND: This study aimed at investigating the effect of rational emotive occupational health coaching on quality of work-life among primary school administrators. …”
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    Rational emotive occupational health coaching for quality of work-life among primary school administrators
  9. 2169
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    Levosimendan in venoarterial ECMO weaning. Rational and design of a randomized double blind multicentre trial
  10. 2170
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    NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
  11. 2171
    por Yuan, Rongrong, Sun, Hao, He, Hongming
    Publicado 2021
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    Rational Construction of a Responsive Azo-Functionalized Porous Organic Framework for CO(2) Sorption
  12. 2172
    “…However, some promiscuous acyltransferases can catalyze acylation in an aqueous solution. In this study, a rational design was performed to enhance the acyltransferase selectivity and substrate scope of the Pyrobaculum calidifontis VA1 esterase (PestE). …”
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    Rational Design for Enhanced Acyltransferase Activity in Water Catalyzed by the Pyrobaculum calidifontis VA1 Esterase
  13. 2173
    “…Prevention of immunogenicity of therapeutic proteins prior to their initial use is critical as it is often difficult to reverse an established immune response. Here, we discuss a rational design and testing of a phosphatidylserine-containing nanoparticle platform for novel oral prophylactic reverse vaccination approach, i.e., pre-treatment of a therapeutic protein in the presence of nanoparticles to prevent immunogenicity of protein therapies.…”
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    Rational design of a nanoparticle platform for oral prophylactic immunotherapy to prevent immunogenicity of therapeutic proteins
  14. 2174
    “…Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. …”
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    Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
  15. 2175
    “…In our previous work, stereocontrolled FRP were gained at the cost of losing the confined inner space, which hampers their host–guest interactions and potential applications. Through a rational design approach, herein we demonstrate the successful construction of hollow FRP with high diastereoselectivity. …”
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    Hollow and highly diastereoselective face-rotating polyhedra constructed through rationally engineered facial units
  16. 2176
    “…In this contribution, the unique and unprecedented stereochemical phenomenon of an aldoxime dehydratase‐catalyzed enantioselective dehydration of racemic E‐ and Z‐aldoximes with selective formation of both enantiomeric forms of a chiral nitrile is rationalized by means of molecular modelling, comprising in silico mutations and docking studies. …”
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    Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach
  17. 2177
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    Studying the Expression Efficiencies of Human Clotting Factor IX Analogs, Rationally-designed for Hyper-glycosylation
  18. 2178
    “…The solution NMR structures of 1, 3, 4, 14 and 16 are determined, supporting structural comparisons that ultimately enabled the rational production of disulfide bond-containing derivatives 18 and 19, whose structures do not belong to any of the four classes currently used to classify lasso peptides. …”
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    Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications
  19. 2179
    “…In this study, a SPase gene from Leuconostoc mesenteroides ATCC 12,291 (LmSPase) was synthesized with optimized codons and overexpressed successfully in Escherichia coli. A semi-rational design strategy that combined the FireProt (a web server designing thermostable proteins), structure–function analysis, and molecular dynamic simulations was used to improve the thermostability of LmSPase. …”
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    Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol
  20. 2180
    “…As a result, we successfully mitigate the particle cracking issue in Ni-rich cathodes via rational concentration gradient design without sacrificing the electrode capacity. …”
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    Rational design of mechanically robust Ni-rich cathode materials via concentration gradient strategy
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