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  1. 29521
    “…Such a feature is characteristic of taxa whose representatives either occupy isolated ecological niches or lack efficient mechanisms for gene exchange and recombination, which seems rational concerning a strictly pathogenic species with clonal population structure. …”
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    Comparative genomics and pangenome-oriented studies reveal high homogeneity of the agronomically relevant enterobacterial plant pathogen Dickeya solani
  2. 29522
    “…WSB was well accepted as an extra ration, LNS was popular due its chocolaty taste and texture, whereas MNP sprinkles were perceived to be of little value. …”
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    Food supplements to reduce stunting in Pakistan: a process evaluation of community dynamics shaping uptake
  3. 29523
    “…RESULTS: All of the CDEs (n = 1142) extracted from the 25 clinical documents were successfully integrated with a very high CDE reuse ratio (46.9%) into 586 CDEs (259 atomic and 20 unique composite CDEs), and all of CDEs (n = 238) extracted from the 14 FHIR resources of FHIR bulk sample data were successfully integrated with high CDE reuse ration (59.7%) into 96 CDEs (21 atomic and 28 unique composite CDEs), which improved the semantic integrity and interoperability without any semantic loss. …”
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    Composite CDE: modeling composite relationships between common data elements for representing complex clinical data
  4. 29524
    “…As 4T1 is a common model for metastatic tumors, our data supports the rational design of mode-of-action studies for pre-clinical evaluation of targeted immunotherapies.…”
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    Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model
  5. 29525
    “…METHODS: First, we identified the medical knowledge that is required to assess the clinical rationality of the claims. We then searched for data sources that contain information to build such knowledge. …”
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    Medical Knowledge Graph to Enhance Fraud, Waste, and Abuse Detection on Claim Data: Model Development and Performance Evaluation
  6. 29526
    “…These innovative findings give a rational pharmacological basis and support for treating COVID-19 and possibly other diseases with LHQW.…”
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    Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW
  7. 29527
    “…BACKGROUND: The general consensus regarding a rational choice among various treatment strategies for medial meniscus posterior root tears (MMPRTs) has yet to be clearly established. …”
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    Repair versus nonrepair of medial meniscus posterior root tear: A systematic review of patients’ selection criteria, including clinical and radiographic outcomes
  8. 29528
    “…If a second spike of virus strikes, rational decision making is required to ensure optimal cancer care.…”
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    Outcomes of the 2019 novel coronavirus in patients with or without a history of cancer: a multi-centre North London experience
  9. 29529
    “…The objective of this study was to develop a novel drug delivery system, solid lipid nanoparticle (SLN), capable of delivering high payload of 5-FU to treat CRC. The rational was to improve 5FU-nanocarrier compatibility and therapeutic efficacy. …”
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    Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer
  10. 29530
    por Xiu, Xiaolei, Qian, Qing, Wu, Sizhu
    Publicado 2020
    “…Especially for the aspects of “rationality of schema structure,” “scalability,” and “readability of results,” the DSTKG performed well, with scores of 4.72, 4.67, and 4.69, respectively, which were much higher than the average. …”
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    Construction of a Digestive System Tumor Knowledge Graph Based on Chinese Electronic Medical Records: Development and Usability Study
  11. 29531
    “…These results will help define a new roadmap towards rational, subtype-specific therapeutic inroads and improved patients’ care.…”
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    A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer
  12. 29532
    por Adraro, Zerihun, Mengistu, Daniel
    Publicado 2020
    “…If the nursing process is not valued and not used, nurses may continue to intervene on the basis of a medical diagnosis rather than on the basis of a rational nursing Process steps. In any of the steps, oversight or omission can result in less than optimal nursing care. …”
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    Implementation and factors affecting the nursing process among nurses working in selected government hospitals in Southwest Ethiopia
  13. 29533
    “…The recent outbreak of COVID-19 in Italy caused a limitation of the resources of the health system, which necessarily led to their rationalization in the critical phase (phase 1) and a reorganization of the system in the following phase (phase 2). …”
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    Surgical management of oncologic patient during and after the COVID-19 outbreak: practical recommendations from the Italian society of Surgical Oncology
  14. 29534
    “…CONCLUSIONS: These findings describe a novel platform for developing patient-derived preclinical tumor models suitable for rationally testing combinatorial ICB in the context of autologous tumor-reactive T cells. …”
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    Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies
  15. 29535
    “…PURPOSE: Rational use of medicines is a necessary constrict towards increasing access for those that desperately need them in society. …”
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    Prescribing for Patients Seeking Maternal and Child Healthcare in Sierra Leone: A Multiregional Retrospective Cross-Sectional Assessments of Prescribing Pattern Using WHO Drug Use Indicators
  16. 29536
    “…Efforts should be paid to promote rational use and ensure the choice of suitable PPI therapy in the future.…”
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    Proton pump inhibitor utilisation and potentially inappropriate prescribing analysis: insights from a single-centred retrospective study
  17. 29537
    “…Immune-high UPS may be the best candidates for immune checkpoint inhibitors, whereas this study provides rational for assessing FGFR inhibition in immune-low UPS. …”
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    High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies
  18. 29538
    “…Earlier and later cTnI concentrations were associated with 30-day complications [adjusted hazard ration (HR) 1.598, 95% confidence interval (CI), 1.158–2.204 and HR 1.499, 95% CI, 1.228–1.831, respectively]. …”
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    Association of early elevated cardiac troponin I concentration and longitudinal change after off-pump coronary artery bypass grafting and adverse events: a prospective cohort study
  19. 29539
    “…Setting individualized alignment target according to original knee phenotype is rational and practical. The residual varus alignment did not cause any aseptic loosening in the 3 years follow-up. …”
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    Total knee arthroplasty according to the original knee phenotypes with kinematic alignment surgical technique—early clinical and functional outcomes
  20. 29540
    “…In particular, the supply of N95 respirator masks has become severely depleted, with supplies having to be rationed and health care workers having to use masks for prolonged periods in many countries. …”
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    Decontamination of N95 masks for re-use employing 7 widely available sterilization methods
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