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  1. 29541
    “…It illustrates how mitochondria dysfunction may play a key role in toxicology and diseases, while paving the way for rational approaches for the design and screening of less toxic derivatives for the benefit of future patients. …”
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    1616. Mechanism of Thrombocytopenia Induced by Oxazolidinones Antibiotics (Linezolid, Tedizolid): Demonstration of Impairment of Megakaryocyte Differentiation From Human Hematopoietic Stem Cells associated with Mitochondrial Toxicity
  2. 29542
    “…The continuous surveillance for antimicrobial resistance and the rational use of antibiotics are crucial in order to improve the prognosis. …”
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    1697. The Burden Of Multidrug-Resistant Urinary Tract Infections
  3. 29543
    “…Involving primary care, with policies for timely referral of suspicious/high-risk preverbal children, plus whole screening at age 3–4 seems a rational/effective way of controlling amblyopia.…”
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    Amblyopia screening effectiveness at 3–4 years old: a cohort study
  4. 29544
    “…Further efforts must be made in order to improve rational prescription of antimicrobials among HCWs in Nigeria. …”
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    Antimicrobial resistance awareness and antibiotic prescribing behavior among healthcare workers in Nigeria: a national survey
  5. 29545
    por Li, Yang, Sun, Jianmin, Wang, Guodong
    Publicado 2021
    “…The results are helpful for restoring a rational lumbar lordosis shape in long fusion surgery.…”
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    Lumbar lordosis morphology correlates to pelvic incidence and erector spinae muscularity
  6. 29546
    “…Inviolability of the prison order over time helps the prison staff to normalize and routinely rationalize punishment enforcement as a power “over” prisoners, but not a power “for” achieving a specific goal. …”
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    More evidence or stronger political will: exploring the feasibility of needle and syringe programs in Ukrainian prisons
  7. 29547
    “…A better understanding of the genetic regulation network of subcutaneous fat tissue is necessary for the rational selection of Chinese domestic pig breeds. …”
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    Comparative analysis of gene expression profiles in differentiated subcutaneous adipocytes between Jiaxing Black and Large White pigs
  8. 29548
    “…Of the eyes, 63.2% (n = 87) presented with macular detachment in the post-COVID group compared with 45% (n = 100) in the pre-COVID group (odds ration [OR], 2.14; 95% confidence interval [CI],1.19–3.86; p = 0.011). …”
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    Impact of the COVID-19 pandemic on characteristics of retinal detachments: the Canadian experience
  9. 29549
    “…Making hard choices for investments in a rational, evidence-informed, systematic, transparent and legitimate manner constitutes an important objective. …”
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    Describing practices of priority setting and resource allocation in publicly funded health care systems of high-income countries
  10. 29550
    “…Forty eight Holstein dairy cows were fed the same total mixed ration under the same housing conditions. Milk and rumen fluid samples were collected from all cows for the analysis of fatty acid profiles (by gas chromatography), the abundances of rumen microbiome communities and genes (by whole-genome-shotgun metagenomics), and rumen metabolome (using 500 MHz nuclear magnetic resonance). …”
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    Unravelling the Role of Rumen Microbial Communities, Genes, and Activities on Milk Fatty Acid Profile Using a Combination of Omics Approaches
  11. 29551
    “…Furthermore, the effects of body condition and feeding system (total mixed ration vs. pasture) on one-carbon metabolism pathways are explored. …”
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    Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, lactation and the neonatal period in dairy cattle
  12. 29552
    “…CONCLUSION: Further, TNM classification based on the intracranial location, extension direction, relationship with brainstem, and neurovascular structures guides preoperative evaluation, rational surgical approach selection, and surgical strategy formulation. …”
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    Surgical Management of Tentorial Notch Meningioma Guided by Further Classification: A Consecutive Study of 53 Clinical Cases
  13. 29553
    “…It is estimated that the high prevalence rate of COVID-19 has been imposing a heavy economic burden on the country and health system directly that may result in rationing or painful cost-control approaches.…”
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    The economic burden of coronavirus disease 2019 (COVID-19): evidence from Iran
  14. 29554
    “…The observations provide new insights that can be applied to the rational design of combinatorial therapies targeting immune checkpoints and cancer metabolism. …”
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    The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
  15. 29555
    “…Mesenchymal stem cells (MSCs) can promote tissue regeneration and modulate immune responses and, thus, have the rational requirements to be used to counteract SARS-CoV-2-induced pneumonia and hyper-inflammation. …”
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    Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 Patients
  16. 29556
    “…CONCLUSION: WIT-induced IRI in muscle requests increased numbers of injected MPC to engraft and persist, suggesting a possible rational for cell therapy to antagonize IRI. Further investigations are needed to evaluate the regenerative capacity and therapeutic advantage of MPC in the setting of ischemic limb injury. …”
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    Myogenic progenitor cell transplantation for muscle regeneration following hindlimb ischemia and reperfusion
  17. 29557
    “…Consequently, nuclear export is a rational target in DDLPS. We directly compared the antitumor activity of the first-in class XPO1 inhibitor selinexor and doxorubicin, the standard front-line therapy in sarcomas, in DDLPS patient-derived xenografts (PDXs) and primary cell lines. …”
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    Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation
  18. 29558
    “…Finally, we analyzed ration of apoptosis, necrosis in gastric cancer cells by using flow cytometry after administration of DGAT1 inhibitor. …”
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    Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer
  19. 29559
    “…Meanwhile, nanotoxicological appraisal proved the biocompatibility of SUL-LPS upon repetitive oral administration. CONCLUSION: Rationally designed lipospheres hold promising in vitro and in vivo characteristics for efficient delivery of SUL with high oral bioavailability, antidepressant activity together with a good safety profile.…”
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    Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity
  20. 29560
    “…Inhalable nanostructured microparticles of simvastatin, a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor, were rationally designed for targeted pulmonary delivery as dry powder inhalers (DPIs) for the treatment of pulmonary hypertension (PH). …”
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    Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy
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