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  1. 29661
    “…Adjusting initial dosage regimens based on CRP may promote the rational use of VRC.…”
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    Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis
  2. 29662
    “…The SII-based nomogram helps doctors make decisions on whether DC is needed timely and rationally, and thereby may improve the prognosis of these patients.…”
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    Systemic immune inflammatory index is an independent predictor for the requirement of decompressive craniectomy in large artery occlusion acute ischemic stroke patients after mechanical thrombectomy
  3. 29663
    “…The results obtained are relevant in the sense that they will allow a rational use of the plants studied in the control of digestive parasites but also to initiate the process of identification of new anthelmintic molecules in the context of the development of resistance against the most currently used anthelmintic molecules. …”
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    Anthelmintic Activity, Cytotoxicity, and Phytochemical Screening of Plants Used to Treat Digestive Parasitosis of Small Ruminants in Benin (West Africa)
  4. 29664
    “…So this study might be helpful in the rational design of either ligands or receptors.…”
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    Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family
  5. 29665
    “…RATIONAL: Lung cancer is the most common tumor worldwide, with the highest mortality rate and second highest incidence. …”
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    Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1–FGL1–MYH9 axis
  6. 29666
    por Wen, Chong, Tang, Jie, Wang, Tao, Luo, Hao
    Publicado 2022
    “…With relatively high accuracy and reliability, the nomogram can help clinicians predict the prognosis of patients and make more rational clinical decisions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02544-y.…”
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    A nomogram for predicting cancer-specific survival for elderly patients with gallbladder cancer
  7. 29667
    “…Here we implement MIF to define the myeloid, T cell, and natural killer (NK) cell compartments in an effort to guide rational design of immunotherapeutic strategies for chordoma. …”
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    Multi-spectral immunofluorescence evaluation of the myeloid, T cell, and natural killer cell tumor immune microenvironment in chordoma may guide immunotherapeutic strategies
  8. 29668
    “…The supplements (vitamin C, 1 g/liter of drinking water and AG, 1% ration) were given for 5 weeks post-vaccination (PV). …”
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    Immunological, biochemical and pathological effects of vitamin C and Arabic gum co-administration on H9N2 avian influenza virus vaccinated and challenged laying Japanese quails
  9. 29669
    “…OBJECTIVE: The objective of this work is to compare demographics, comorbidities, clinical symptoms, biology and imaging findings between severe and non-severe COVID-19 patients and to identify clinical and biological risk factors and biomarkers for the development of severe COVID-19 as well as predictive thresholds for severity in order to best rationalize management and decrease the morbidity and mortality caused by this condition. …”
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    Comparative analysis of clinical and biological characteristics of COVID-19 patients: A retrospective cohort study
  10. 29670
    “…OBJECTIVE: This study was designed to analyze the clinical characteristics, etiological characteristics, drug resistance, and empirical use of antibiotics for community-acquired pyogenic liver abscess (PLA) to provide a basis for rational and effective empirical treatment of PLA in the local area. …”
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    Clinical Characteristics of 606 Patients with Community-Acquired Pyogenic Liver Abscess: A Six-Year Research in Yantai
  11. 29671
    por Cheng, Jie, Zhang, Shuwen, Sheng, Weibin
    Publicado 2022
    “…CONCLUSION: For AS patients with thoracolumbar or lumbar kyphosis, the SFA method, FBI method, and Surgimap method can be used to predict the osteotomy angle precisely, however, considering the rationality of parameter settings and the operability, SFA method is relatively more suitable for such population.…”
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    Evaluation of preoperative calculation methods of osteotomy size in ankylosing spondylitis with thoracolumbar or lumbar kyphosis
  12. 29672
    “…Since this NHL subtype is extremely rare in children and adolescents, to improve the understanding of this disease and standardize its rational treatment, we retrospectively summarized the treatment regimens of 18 pathologically diagnosed children with SPTCL to compare the clinical efficacy of multidrug chemotherapy and immunomodulatory therapy. …”
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    A retrospective study of 18 children with subcutaneous panniculitis-like T-cell lymphoma: multidrug combination chemotherapy or immunomodulatory therapy?
  13. 29673
    “…This study aims to supplement economic evidence by comparing the cost-effectiveness between imatinib and dasatinib in treating pediatric patients with Ph+ ALL in China, and to help clinical rational drug use via multi-dimensional value assessment. …”
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    Cost-effectiveness analysis of dasatinib versus imatinib in pediatric philadelphia chromosome-positive acute lymphoblastic leukemia patients in China
  14. 29674
    “…Pharmacists made 196 suggestions mainly related to rational use of the medications and management of ADRs. …”
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    Pharmacist-led olaparib follow-up service for ambulatory ovarian cancer patients: A prospective study in a tertiary specialized cancer hospital in China
  15. 29675
    “…RESULTS: Through systematic enzyme engineering, combining enzyme-directed evolution and rational design, we changed the optimal pH of the laccase for oxidation of lignin phenols from acidic to basic, enhanced the catalytic activity at alkaline pH and increased the thermal tolerance of the enzyme by accumulating up to eight mutations in the protein sequence. …”
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    Tailor-made alkaliphilic and thermostable fungal laccases for industrial wood processing
  16. 29676
    “…Through an appropriate stratification of patients, rational allocation of the available hospital resources can be accomplished. …”
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    Prognostication of COVID-19 patients using ROX index and CURB-65 score - A retrospective observational study
  17. 29677
    “…Notably, the growth in the number of patients with acute ischemic stroke who underwent ITT benefited from both the “stroke emergency map” of China and the “green channel,” a novel treatment approach that focuses on the rational design of the rescue process. Trial registration. …”
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    The effects of the coronavirus disease pandemic on intravenous thrombolytic therapy among patients with acute ischemic stroke in Dalian, China
  18. 29678
    “…These results provide mechanistic rational for combination of chemotherapy with inhibition of JAK2/STAT3 signaling as a more effective therapeutic strategy in IBC. …”
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    JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States
  19. 29679
    “…We then used the MDA values to verify the rationality of these partitionings. Finally, four network models were used for comparison and training: VGG19, EfficientNetB7, ResNet152V2, and spatial attention and spatial enhancement network combined with ResNet152V2 (ResNet152V2-SA-SE). …”
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    Intelligent grading method for walnut kernels based on deep learning and physiological indicators
  20. 29680
    “…INTRODUCTION: Probiotic administration seems to be a rational approach to promote maturation of the neonatal immune system. …”
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    Effect of early postnatal supplementation of newborns with probiotic strain E. coli O83:K24:H31 on allergy incidence, dendritic cells, and microbiota
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