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29681por González-Herrera, Fabiola, Clayton, Natasha S., Guzmán-Rivera, Daniela, Carrillo, Ileana, Castillo, Christian, Catalán, Mabel, Anfossi, Renatto, Quintero-Pertuz, Helena, Quilaqueo, María Elena, Olea-Azar, Claudio, Rivera-Meza, Mario, Kemmerling, Ulrike, Ridley, Anne J., Vivar, Raúl, Maya, Juan Diego“…Thus, the use of immunomodulators is a rational alternative to CCC. Rho-associated kinase (ROCK) 1 and 2 are RhoA-activated serine/threonine kinases that regulate the actomyosin cytoskeleton. …”
Publicado 2023
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29682por Xiang, Song, Long, Xincheng, Tu, Qiuxia, Feng, Jian, Zhang, Xiaohe, Feng, Guangwei, Lei, Li“…In this study, a hemin-based peptide assembly was rationally designed for the colorimetric detection of active small molecules. …”
Publicado 2023
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29683por Wong, Jeffrey L., Smith, Patrick, Angulo-Lozano, Juan, Ranti, Daniel, Bochner, Bernard H., Sfakianos, John P., Horowitz, Amir, Ravetch, Jeffrey V., Knorr, David A.“…Despite strong preclinical rationale, systemic administration of therapeutic agonistic antibodies targeting the CD40 pathway have demonstrated dose limiting toxicities with minimal clinical activity to date, emphasizing an important need for optimized CD40-targeted approaches, including rational combination therapy strategies. Here, we describe an important role for the endogenous IL-15 pathway in contributing to the therapeutic activity of CD40 agonism in orthotopic bladder tumors, with upregulation of trans-presented IL-15/IL-15Rα surface complexes, particularly by cross-presenting cDC1s, and associated enrichment of activated CD8 T cells within the bladder tumor microenvironment. …”
Publicado 2023
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29684por Ma, Yuan, Xiao, Pei, Yu, Li, Ni, Henfan, Huang, Shiyao, Wang, Meixian, Huang, Yuxiang, Li, Li, Yang, Lian, Tan, Chunjian, Zhong, Zhigang“…The purpose of this study is to analyze the allocation of health human resources in Chinese maternal and child health care institutions, evaluate the fairness of the allocation, to provide a reference for the rational allocation of MCH human resources. METHODS: The data of health technicians, licensed (assistant) physicians, and registered nurses in maternal and child health care institutions nationwide from 2016 to 2020 were included. …”
Publicado 2023
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29685“…In order to promote more rational utilization, the role and progress of AI in this field were reviewed. …”
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29686“…Knowing gestational age and living close to health facilities were associated with a lower likelihood of practicing self-medication. Rational drug use has to be promoted among pregnant women. …”
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29687“…As antibiotic resistance is growing, it is imperative to rationalize the usage of antibiotics when a patient is operated for hypospadias. …”
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29688por Scherer, Philipp O J“…A comparison of several methods for quantum systems is performed, containing pseudo-spectral methods, finite differences methods, rational approximation to the time evolution operator, second order differencing and split operator methods. …”
Publicado 2013
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29689por Salzmann, Martin, Wald, Alexander, Stege, Henner, Loquai, Carmen, Zimmer, Lisa, Hayani, Kinan M., Heinzerling, Lucie, Gutzmer, Ralf, Enk, Alexander H., Hassel, Jessica C.“…We conclude that switching to a different BRAFi+MEKi combination if dose-limiting toxicity occurs is a feasible and rational approach in patients with metastatic melanoma.…”
Publicado 2023
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29690por Wu, Junzhen, Yang, Xinyi, Wu, Jufang, Wang, Jingjing, Wu, Hailan, Wang, Yu, Yuan, Hong, Yang, Huahui, Wang, Hailin, Zhang, Jing“…This study aimed to assess whether it is required to adjust the dose of contezolid in patients with moderate hepatic impairment for clinicians to use the drug more rationally. Methods: A single-center, open-label, parallel-group study was conducted to compare the pharmacokinetic (PK) parameters of contezolid and its metabolite M2 between the patients with moderate hepatic impairment and healthy controls with normal liver function after oral administration of 800 mg contezolid tablets. …”
Publicado 2023
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29691“…A dataset comprising ration analyses as well as individual daily milk yields (MY), dry matter intake (DMI), body weights, and health records of 417 lactations (298 cows) was used to calculate individual daily GB and energy balance (EB). …”
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29692por Castro, Abril C., Cascella, Michele, Perutz, Robin N., Raynaud, Christophe, Eisenstein, Odile“…This shielding arises from the magnetic coupling of the Ni(3d)/F(2p lone pair) orbitals with the vacant σ(Ni–F)(*) orbital, thereby rationalizing the very highly upfield (shielded) resonance of the component (δ(33)) along this direction. …”
Publicado 2023
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29693por Rehemujiang, Halidai, Yusuf, Hassan Ali, Ma, Tao, Diao, QiYu, Kong, Luxin, Kang, Lingyun, Tu, Yan“…BACKGROUND: This study examined the effects of substituting cottonseed meal (CSM) or rapeseed meal (RSM) for soybean meal (SBM) on Hu sheep performance, rumen fermentation, and bacterial composition. 51 four-month-old indigenous male Hu sheep with starting body weights of 22.51 ± 2.84 kg and similar origins were randomly assigned to three treatments; (1) non-fermented total mixed ration (TMR) with SBM (CK), (2) fermented TMR containing CSM (F-CSM group), and (3) fermented TMR containing RSM (F-RSM group). …”
Publicado 2023
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29694por Farrow, Luke, Redmore, James, Talukdar, Partha, Clement, Nick, Ashcroft, George P.“…Current demand far exceeds available resource, and therefore it is integral that healthcare resource is fairly rationed to those who need it most. We therefore set out to determine if pre‐operative health‐related quality of life assessment (HRQoL) could be used to triage arthroplasty waiting lists. …”
Publicado 2022
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29695por Leblond, Pierre, Tresch-Bruneel, Emmanuelle, Probst, Alicia, Néant, Nadège, Solas, Caroline, Sterin, Arthur, Boulanger, Thomas, Aerts, Isabelle, Faure-Conter, Cécile, Bertozzi, Anne-Isabelle, Chastagner, Pascal, Entz-Werlé, Natacha, De Carli, Emilie, Deley, Marie-Cécile Le, Bouche, Gauthier, André, Nicolas“…SIMPLE SUMMARY: This study tested the repurposing of two rationally selected, non-anticancer drugs as a way to address the need for less toxic therapeutic options in children with gliomas. …”
Publicado 2023
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29696por Ponticiello, Matthew, Nuwagira, Edwin, Tayebwa, Mellon, Mugerwa, Joseph, Nahabwe, Hellen, Nakasita, Catherine, Tumuhimbise, John Bosco, Lam, Nicholas L, Wiens, Matthew O, Vallarino, Jose, Allen, Joseph G, Muyanja, Daniel, Tsai, Alexander C, Sundararajan, Radhika, Lai, Peggy S“…Household relationships improved with access to lighting because of reduced conflicts over light rationing. Participants also described a communal benefit of lighting due to improved feelings of safety. …”
Publicado 2023
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29697por Zhang, Jun, Liu, Wenli, Shi, Linyu, Liu, Xu, Wang, Mengchun, Li, Wanting, Yu, Daijing, Wang, Yaya, Zhang, Jingjing, Yun, Keming, Yan, Jiangwei“…Understanding the effects of drug addiction and detoxification on oral microbial communities will promote a more rational approach for recovering the oral function and health of drug users. …”
Publicado 2023
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29698por Han, Renru, Shen, Siquan, Yin, Dandan, Ding, Li, Shi, Qingyu, Yang, Yang, Guo, Yan, Wu, Shi, Zhi, Peiyuan, Zhu, Demei, Hu, Fupin“…The accurate detection of ceftazidime-avibactam susceptibility is of great significance for the rational clinical application of drugs. Here, we evaluated the performance of the ceftazidime-avibactam 10/4-μg and 30/20-μg disk diffusion tests, compared with the reference broth microdilution method, with clinical Enterobacterales and P. aeruginosa isolates.…”
Publicado 2023
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29699por Mitra, Biplab, Singha, Prantick, Roy Chowdhury, Arnab, Sinha, Abhas Kumar, Skalicky, Milan, Brestic, Marian, Alamri, Saud, Hossain, Akbar“…From these 2-year field trials, it can be concluded that applying a normalized difference vegetation index sensor could be an essential tool for the rational management of fertilizer nitrogen in wheat grown in eastern sub-Himalayan plains.…”
Publicado 2023
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29700“…The results here can lay the foundation for the rational application of high-concentration diets in production. …”
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