“…Pattern of Antibiotic Consumption among ≤5-Year Children in Low-Income Urban Bangladesh [Figure: see text] CONCLUSION: Intervention packages are required to improve parents’ knowledge and awareness on the rational use of antibiotic. Strengthening the health system could enhance the optimum use of antibiotics and combat antibiotic resistance. …”
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“…Binary logistic regression analysis was conducted to rationalize the study's objectives. The pooled COVID-19 booster vaccine acceptance rate was 70.0 % (95 % confidence Interval [CI]: 67─73) among Bangladeshi people. …”
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“…Using a design period of 25 years for culverts, the modified rational method was used to determine the Peak flow of the catchment. …”
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“…BACKGROUND: Corynebacterium glutamicum is a high-GC Gram-positive soil bacterium of great biotechnological importance for the production of amino acids. To facilitate the rational design of sulphur amino acid-producing strains, the pathway for assimilatory sulphate reduction providing the necessary reduced sulfur moieties has to be known. …”
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“…Several methods for the targeted genetic manipulation of this organism and rational strain improvement have been developed. An efficient transposon mutagenesis system for the completely sequenced type strain ATCC 13032 would significantly advance functional genome analysis in this bacterium. …”
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“…BACKGROUND: The rational design of L-phenylalanine (L-Phe) overproducing microorganisms has been successfully achieved by combining different genetic strategies such as inactivation of the phosphoenolpyruvate: phosphotransferase transport system (PTS) and overexpression of key genes (DAHP synthase, transketolase and chorismate mutase-prephenate dehydratase), reaching yields of 0.33 (g-Phe/g-Glc), which correspond to 60% of theoretical maximum. …”
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“…In addition to providing a rationalization of relative strand polarity with nucleic acids, the backbone-base inclination parameter is also a determinant of cross-pairing. …”
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“…The growth in the intensity of the disease may be in part ascribed to an accumulation on the soil of infectious agents during any given season after they had been introduced, but it is hardly acceptable as an explanation from season to season, when the soul was either virgin, as regards poultry yards, or ploughed deep and seeded before use. A more rational hypothesis is the gradual attraction of birds in larger numbers and greater variety on account of the food supply in the turkey enclosures and the more intensive cultivation of the land surrounding the laboratory and animal buildings since the beginning of the experiments in 1917. …”
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“…Stipulated selenium concentrations in the rations were below 0.40 mg/kg dry matter. In addition 20 male lambs were given supplements from November until they were slaughtered in March. …”
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“…The same total amount of liquid feed was fed to each group and the feed ration was correlated to the live weight of the pigs. …”
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“…Based on these evidences, I propose that a rational combination of ω-3 and ω-6 fatty acids and the co-factors that are necessary for their appropriate action/metabolism is as beneficial as that of the combined use of a statin, thiazide, a β blocker, and an angiotensin converting enzyme (ACE) inhibitor, folic acid, and aspirin. …”
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“…CONCLUSION: This data supports the policy of rational use of blood transfusion, as proposed in the WHO guidelines, for children with anaemia in areas where access to emergency transfusion is not guaranteed. …”
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“…Here, we have used this system to further explore the budding process by analyzing elements within the M protein that are critical for particle release. RESULTS: Using rationally targeted site-directed mutagenesis we show that a NiV M sequence YPLGVG is required for M budding and that mutation or deletion of the sequence abrogates budding ability. …”
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“…These results should inform education of health professionals and rational drug use policies to reduce poly-pharmacy, and also suggest a potential positive impact of increased access to testing for malaria both within health facilities and in homes.…”
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“…CONCLUSION: The present work brought out that the use of chemotaxonomic tools and a priori knowledge of fungal extrolites is a rational approach towards selection of fungal polyketide pigment producers considering the enormous chemical diversity and biodiversity of ascomycetous fungi. …”
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“…Further work is needed to understand the mechanisms of this effect, including the potential for rational combination of GSK3 inhibitors with other targeted agents for the treatment of pancreatic cancer.…”
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“…AL can be a viable alternative of artesunate plus sulphadoxine/pyrimethamine (AS + SP), however, the drug should be used rationally and efficacy needs to be monitored periodically.…”
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“…These novel anti-tumor activities of IL-12 add to the well known immune-modulatory properties of the cytokine and may provide a rational basis for the development of a clinical trial.…”
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“…CONCLUSIONS: Present results provide novel evidence on the molecular basis of tumor growth inhibition mediated by mastic oil and set a rational basis for application of genomics and bioinformatic methodologies in the screening of natural compounds with potential cancer chemopreventive activities.…”
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“…The reaction mechanism we describe here may also be appropriate for the analysis of other types of GABA(A) receptors and provides a framework for rational investigation of the kinetic effects of a variety of therapeutic agents that activate or modulate GABA(A) receptors and hence influence synaptic and extrasynaptic inhibition in the central nervous system.…”
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