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  1. 29781
    “…This may compromise rational control despite costly prevention strategies. …”
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    Characterisation of Clostridium difficile Hospital Ward–Based Transmission Using Extensive Epidemiological Data and Molecular Typing
  2. 29782
    “…The complexity of the intra- and extracellular cation effects can be rationalized by a kinetic model suggesting that cations reach the binding sites through a rather high-field intra- and a rather low-field extracellular access channel, with fractional electrical distances of ∼0.5 and ∼0.2, respectively.…”
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    Control of Gastric H,K-ATPase Activity by Cations, Voltage and Intracellular pH Analyzed by Voltage Clamp Fluorometry in Xenopus Oocytes
  3. 29783
    “…The finding of a STAT3-specific hpdODN establishes the first rational basis for designing STAT3 DBD-specific inhibitors.…”
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    A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line
  4. 29784
    “…As toxicological data may come from different, heterogeneous sources, a deployed ontology, unifying the terminology and the resources, is critical for the rational and reliable organization of the data, and its automatic processing. …”
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    OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia
  5. 29785
    “…BACKGROUND: Protein structures provide a valuable resource for rational drug design. For a protein with no known ligand, computational tools can predict surface pockets that are of suitable size and shape to accommodate a complementary small-molecule drug. …”
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    Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets
  6. 29786
    por Melnik, Bodo
    Publicado 2012
    “…These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. …”
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    Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet
  7. 29787
    “…Understanding the mechanisms of COX-2 expression and PGE(2) release regulated by ET-1/ET(B) system on brain microvascular endothelial cells may provide rational therapeutic interventions for brain injury and inflammatory diseases.…”
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    c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells
  8. 29788
    “…Other effective measures, such as health education to increase awareness of mothers' knowledge, and improving training of health staff in evidence-based delivery care, maybe could do more to promote rational baby delivery in rural China.…”
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    Impact of alternative reimbursement strategies in the new cooperative medical scheme on caesarean delivery rates: a mixed-method study in rural China
  9. 29789
    “…Due to the high costs associated with purification of recombinant proteins the protocols need to be rationalized. For high-throughput efforts there is a demand for general methods that do not require target protein specific optimization(1) . …”
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    Orthogonal Protein Purification Facilitated by a Small Bispecific Affinity Tag
  10. 29790
    “…At the same time, understanding the mechanisms that underlie SPMS is critical to the development of rational therapies for this untreatable stage of the disease. …”
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    Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS)
  11. 29791
    “…A secondary objective was to formulate a rational blood ordering practice for elective procedures for these departments. …”
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    Maximum surgical blood ordering schedule in a tertiary trauma center in northern India: A proposal
  12. 29792
    “…The literature contrasts “rational-analytic” vs. “naturalistic-intuitive” decision-making styles, but the best approach is often a balanced approach that combines both styles. …”
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    Advancing clinical decision support using lessons from outside of healthcare: an interdisciplinary systematic review
  13. 29793
    “…Finally, by comparing the four structures we propose maps of the peptide-enzyme interactions that should help rationalizing substrate-specificity and lay the ground for inhibitor design.…”
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    Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases
  14. 29794
    “…After identifying problems with usage and completing a cefepime use evaluation for cycle A, 2 months of educational intervention among professionals were given and a more effective and rational system of cefepime use was set up. During the 2 months, the lectures were arranged and attendance of prescribers was required. …”
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    Drug use evaluation of cefepime in the first affiliated hospital of Bengbu medical college: a retrospective and prospective analysis
  15. 29795
    “…The range of pathogens, antimicrobial susceptibility, and co-morbidities associated with mortality described will be of use in the development of rational guidelines for infectious disease treatment and control in Cambodia and South-East Asia.…”
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    A Prospective Study of the Causes of Febrile Illness Requiring Hospitalization in Children in Cambodia
  16. 29796
    “…The results obtained provide critical information for rational vaccine study design. Literature meta-analysis is generic and can be applied to analyze variables critical for vaccine protection against other infectious diseases.…”
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    Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates
  17. 29797
    “…Extensive health education campaigns should be provided to the patients in the hospital as well as in community settings for rational control and management of the disease.…”
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    A cross-sectional assessment of knowledge, attitude and practice among Hepatitis-B patients in Quetta, Pakistan
  18. 29798
    “…Six heifers were fed three experimental rations throughout three periods. The diets were characterised by different starch levels: high starch (HS), medium starch (MS) and low starch, as the control diet (CT). …”
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    Effect of induced ruminal acidosis on blood variables in heifers
  19. 29799
    “…In order to deal with the high data imbalance problem and the high signal-to-noise ration, we casted the problem in a semi-supervised setting. …”
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    Semi-Supervised Prediction of SH2-Peptide Interactions from Imbalanced High-Throughput Data
  20. 29800
    “…Plasmodial FPPS represents a potential target for the rational design of chemotherapeutic agents to treat malaria.…”
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    Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
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