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  1. 29841
    “…Currently there is no way to identify likely responders or rational combinations with the potential to improve HER2-focussed treatment outcome. …”
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    Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment
  2. 29842
    “…These contradictory findings provide the rational basis for studies of BIVA-assisted fluid management in ICU patients. …”
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    Bioelectrical impedance vector analysis in critically ill patients: a prospective, clinician-blinded investigation
  3. 29843
    “…Reforms should consider ways to reduce medicine prices and promote rational use, strengthen administrative controls, and increase incentives for quality health care provision. …”
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    Barriers to universal health coverage in Republic of Moldova: a policy analysis of formal and informal out-of-pocket payments
  4. 29844
    “…CONCLUSION: Multimodal pre-emptive analgesia could significantly lower VAS score, inhibit stress response, and reduce inflammatory response in patients undergoing transabdominal hysterectomy, which can be a rational strategy for pain control in future. TRIAL REGISTRATION: ChiCTR-IPR-15005848 on January 17, 2015.…”
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    Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial
  5. 29845
    “…This approach may be useful to rationalize resources. METHODS: From 2006, all patients operated for an early stage CC (I, IIA, IIB) according to the 7th edition of the AJCC-2010 classification entered in a prospective surveillance program in accordance to our local guidelines. …”
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    Surveillance for early stages of colon cancer: potentials for optimizing follow-up protocols
  6. 29846
    “…The priority these trusted sources place on providing biological information overshadows learning about emotional and relational aspects of sexuality. This biological rationalization of adolescent sexual behaviour neglects the way gender inequality, peer-pressure, coercion, media eroticization and religion influence adolescent sexual decision-making. …”
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    From disease to desire, pleasure to the pill: A qualitative study of adolescent learning about sexual health and sexuality in Chile
  7. 29847
    “…As health systems and physicians collaborate to improve health care quality and value for patients, accurate information on cost will be important for providers. Rational variation in health care costs, which arise from patient-centered care, is appropriate. …”
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    Variation in Health Care Cost: Quality, Utilization, and Efficiency Review for ACL Surgery Cost Variance Within a Health Care System
  8. 29848
    “…The results demonstrate need to develop diagnosis-specific prescribing guidelines to facilitate rational use of antibiotics and implement antibiotic stewardship program.…”
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    Antibiotic Prescribing among Pediatric Inpatients with Potential Infections in Two Private Sector Hospitals in Central India
  9. 29849
    “…Water was supplied ad libitum and daily rations were determined according to the nutrient suggestions for poultry. …”
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    Effect of Monochromatic Light on Expression of Estrogen Receptor (ER) and Progesterone Receptor (PR) in Ovarian Follicles of Chicken
  10. 29850
    “…These findings provide a novel understanding of the molecular pathogenesis of chlamydia-associated diseases, which may guide a rational prevention strategy.…”
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    Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis
  11. 29851
    “…To maintain the sustained effectiveness carbamates and organophosphates as alternative products to pyrethroids for malaria vector control, monitoring of duplicated resistant alleles in natural populations is essential to guide the rational use of these insecticides. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12936-015-1026-3) contains supplementary material, which is available to authorized users.…”
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    Estimation of allele-specific Ace-1 duplication in insecticide-resistant Anopheles mosquitoes from West Africa
  12. 29852
    “…Methods for minimizing immune response on L-asparaginase treatment in human include bioengeneering of less immunogenic version of the enzyme or utilizing the homologous enzymes of different origin. To rationalize these approaches we compared immunogenicity of L-asparaginases from five bacterial organisms and performed sequence-structure analysis of the presumable epitope regions. …”
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    Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases
  13. 29853
    “…As most existing computational models assume that similar compounds are likely to interact with similar target proteins and achieve remarkable performance, it is rational to identify potential negative samples based on the converse negative proposition that the proteins dissimilar to every known/predicted target of a compound are not much likely to be targeted by the compound and vice versa. …”
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    Improving compound–protein interaction prediction by building up highly credible negative samples
  14. 29854
    “…Retigabine (RTG), a K(v)7.2/ K(v)7.3-channel opener, seems to be a rational antiepileptic drug for epilepsies caused by KCNQ2 mutations. …”
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    Retigabine, a K(v)7.2/K(v)7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations
  15. 29855
    “…These estimates provide a rational starting point for selecting IMRT boosts for FDG-avid tumors. …”
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    Estimate of the impact of FDG-avidity on the dose required for head and neck radiotherapy local control
  16. 29856
    por Wang, Da, Li, Fu-Li, Wang, Shi-An
    Publicado 2016
    “…This study engineered a natural S. cerevisiae strain with advantages in inulin utilization to produce ethanol from inulin resources by consolidated bioprocess. Rational engineering strategies were employed, including secretive co-expression of heterologous exo- and endo-inulinases, repression of a protease, and switch between haploid and diploid strains. …”
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    Engineering a natural Saccharomyces cerevisiae strain for ethanol production from inulin by consolidated bioprocessing
  17. 29857
    “…One of the hallmarks of double QDs is the observation of dual-color emission from a single nanoparticle, which allows for detailed spectroscopy of their properties down to the single particle level. Furthermore, rational design of the two coupled subsystems enables one to tune the emission statistics from single photon emission to classical emission. …”
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    Colloidal Double Quantum Dots
  18. 29858
    “…QSAR, virtual screening and docking methods increase the potential of rational drug design. The diverse cerebral mechanisms implicated in Central Nervous System (CNS) diseases together with the heterogeneous and overlapping nature of phenotypes indicated that multitarget strategies may be appropriate for the improved treatment of complex brain diseases. …”
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    Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies
  19. 29859
    “…These differences provide a rational basis on which to develop and assess new therapeutic strategies for cognition and behaviour in these disorders.…”
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    Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson’s disease
  20. 29860
    “…The results demonstrate the applicability of the Als adhesin model and provide a rational framework for the enhancement or inhibition of flocculation in industrial applications.…”
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    Force Sensitivity in Saccharomyces cerevisiae Flocculins
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