“…Strategies to overcome these obstacles include modifications of the viral capsid, through rational design or directed evolution, which allow resistance to the immune system, enhancement of penetration through the inner limiting membrane or reduced degradation by intracellular proteasomes. …”
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“…Although these findings need to be confirmed in larger prospective cohorts, they can represent a rational basis for testing the hypothesis that the GEMnPAC schedule may be used as an immunotherapy-modulating regimen in PDAC patients due to its capability of increasing PD-L1 mRNA expression. …”
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“…Based on mechanistic considerations, hydroxocobalamin is a rational choice for treating azide poisoning.…”
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“…RATIONAL & OBJECTIVE: Neighborhood socioeconomic status (SES) and health insurance status may be important upstream social determinants of chronic kidney disease (CKD), but their relationship remains unclear. …”
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“…Taken together, we complement the study of RNA element function in the 3′UTR region of JEV by providing a new target for the rational design of live attenuated candidate vaccines and the increase of virus production.…”
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“…As SHMT2 inhibitors have not yet reached the clinic, these findings may aid the rational design of PLP-competitive SHMT2 inhibitors based on the biguanide skeleton of metformin. …”
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“…Characterizing common co-occurring alterations and immunotherapy biomarkers, including those present before or acquired after treatment, may be critical for predicting responses to MET inhibitors and informing rational combination strategies.…”
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“…Rational: Tumor immunogenic cell death (ICD), induced by certain chemotherapeutic drugs such as doxorubicin (Dox), is a form of apoptosis potentiating a protective immune response. …”
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“…In-depth knowledge of the mutation spectrum of the target population and of the relatively small number of recurrent mutations is crucial to develop a specific cost-effective strategy for mutation screening and a program for breast–ovarian cancer control and prevention through more liberal, yet rational, genetic testing and counseling. ABSTRACT: BRCA1/2-associated hereditary breast and ovarian cancer is the most common form of hereditary breast and ovarian cancer and occurs in all ethnicities and racial populations. …”
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“…MFR did not affect corticosterone concentrations. In conclusion, the ration setting applied slightly involved the energy homeostasis and metabolism of the animals, but their overall metabolic condition, productive performance and welfare were not compromised.…”
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“…Conclusion On the whole, the principles of rational prescription were followed in accordance with the different WHO drug usage indicators. …”
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“…Future work will include the development of a user-friendly booklet on clinical relevant drug-drug interactions in elderly patients using APs, expected to contribute to enhanced patient safety and a more rational use of medicines.…”
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“…As pharmacology subjects are taught in the early years of the course, antibiotic therapeutics should be reinforced later during the study cycle, and students should be made aware of the importance of a rational and adequate use of antibiotics in dental practice. …”
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“…The interaction between those proteins is therefore a promising target toward a rational drug design which could lead to new therapeutic strategies due to the bottleneck nature of HIV-1 nuclear import.…”
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“…Thus, it not only helps researchers develop a more comprehensive understanding of the current publication status and trends in anesthesiology, but also provides a basis for national academic organizations to frame relevant anesthesiology development policies and rationalize resource allocation.…”
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“…To evaluate the sensor performance under different feeding scenarios, the animals were divided into four groups and fed three different types of feed (total mixed ration, long hay, animals allowed to graze). Recordings of hourly rumination and feeding time produced by the sensor were compared with visual observation by scan sampling at 1 minute intervals using Spearman correlation, concordance correlation coefficient (CCC), Bland–Altman plots and linear mixed models for assessing the precision and accuracy of the system. …”
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“…These results suggested that FRS has high a nutritional value and digestibility, is a good feed resource, and showed favorable effects when supplemented with dairy buffalo ration.…”
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“…Each child was provided with a daily ration of either LIBS or CSB+ for 12 weeks. Both intention-to-treat (ITT) and per-protocol (PP) analyses were done. …”
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“…Twelve Holstein dairy cows were randomly allocated into two groups. A total mixed ration supplemented with BLE at 0 (CON) and 1.3 g/kg dry matter (DM) were fed, respectively. …”
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“…The injury rate was computed as the number of injuries per the total number of AEs and reported as a ration of injuries per 10,000 exposures. The ratio was then reported as overall number as well as stratified for event, time of season, and athletic NCAA division. …”
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