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  1. 30161
    “…Unilateral stimulation is an effective type of SCS in the treatment of pain syndromes. adaptive stim is usually not applicable for lead implantation at the cervical level. Nevertheless, the rational use of stimulation at threshold values allowed our patient to use adaptive stim in a non‐standard situation.…”
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    Epidural unilateral stimulation with “adaptive stim” option in treatment of type II CRPS
  2. 30162
    “…These mild differences are rationalized by density-functional theory (DFT) calculations. …”
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    A New Oxygen Containing Pyclen-Type Ligand as a Manganese(II) Binder for MRI and (52)Mn PET Applications: Equilibrium, Kinetic, Relaxometric, Structural and Radiochemical Studies
  3. 30163
    “…The immune microenvironment and inflammatory response participate in the whole process of IS occurrence and development. Therefore, the rational use of relevant markers or characteristic pathways in the immune microenvironment will become one of the important therapeutic strategies for the treatment of IS. …”
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    Comprehensive Landscape of Immune Infiltration and Aberrant Pathway Activation in Ischemic Stroke
  4. 30164
    “…Furthermore, due to the increased survival rates and CD8+ T cells dependence, our model will enable study of the immunological correlates of protection for VC2 OVT and OVT in general, as well as to inform the rational design of future OVs with improved therapeutic potentials.…”
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    45724 VC2 Oncolytic Virotherapy Induces Robust Systemic Anti-Tumor Immunity and Increases Survival in an Immunocompetent B16F10-derived Mouse Melanoma Model
  5. 30165
    “…Additional work in this area, as well as further network analyses, will confer better sense of how to rationally utilize brain organoids for translational purposes.…”
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    96101 Temporal Evolution of Neural Activity in Human Brain Organoids
  6. 30166
    “…Understanding how the virus is spreading within and between communities is vital for the design of rational, evidence-based control measures. METHODS/STUDY POPULATION: We obtained an aliquot of 500ul - 1 ml of inactivated viral transport media (VTM) from positive SARS-CoV-2 nasopharyngeal swabs as determined by qPCR from the New Mexico Department of Health, TriCore Reference Laboratory, Idaho Bureau of Laboratories, and Wyoming Public Health Laboratory. …”
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    16306 Genomic epidemiology of SARS-CoV-2 across New Mexico and the Mountain West
  7. 30167
    por Awuni, Elvis
    Publicado 2022
    “…The peptide sequences could be useful in a rational antimicrobial peptide hybridization strategy to design novel antibiotics. …”
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    Modeling the MreB-CbtA Interaction to Facilitate the Prediction and Design of Candidate Antibacterial Peptides
  8. 30168
    “…In summary, the present report provides further evidence that InPeps have biological significance and could be valuable tools for the rational design of therapeutic molecules targeting intracellular PPI.…”
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    Effect of FKBP12-Derived Intracellular Peptides on Rapamycin-Induced FKBP–FRB Interaction and Autophagy
  9. 30169
    “…In conclusion, present study provides insight about the different biological potentials of S. papilionacea and T. glaberrima extracts that rationalize the applications of these extracts in functional foods and herbal drugs for the management of oxidative-stress related diseases, antimicrobial infections and liver and skin cancer.…”
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    Antioxidant, Anticancer, and PXR-Dependent CYP(3)A(4) Attributes of Schweinfurthia papilionacea (Burm.f.) Boiss., Tricholepis glaberrima DC. and Viola stocksii Boiss
  10. 30170
    “…DISCUSSION: Accordingly, with increasing cases of COVID‐19, many countries such as Germany, Pakistan, Canada, Thailand, and the United Kingdom have started administering the heterologous vaccination as the technique aids to rationalize the usage of the available vaccines to aid in the global race to vaccinate majority to curb the spread of COVID‐19 efficiently. …”
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    Revival of the heterologous prime‐boost technique in COVID‐19: An outlook from the history of outbreaks
  11. 30171
    “…Overall, iTN656 provides a powerful systems biology platform for gaining insights into cell metabolism of lactic acid bacteria and guiding the rational development of synthetic media design for scale-up of probiotic production in industrial scale. …”
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    Probing Genome-Scale Model Reveals Metabolic Capability and Essential Nutrients for Growth of Probiotic Limosilactobacillus reuteri KUB-AC5
  12. 30172
    “…Two explanations are put forward to rationalize this process, namely, the rhythmic pattern is to (1) reduce water loss or (2) facilitate gaseous exchange in environments with high carbon dioxide and low oxygen. …”
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    Why Do Insects Close Their Spiracles? A Meta-Analytic Evaluation of the Adaptive Hypothesis of Discontinuous Gas Exchange in Insects
  13. 30173
    “…In the present work, 1HE variants were developed using random mutagenesis and phage display to enable optimization of tumor penetration and efficacy of trastuzumab-based therapeutics. To guide the rational selection of a particular 1HE mutant for a specific trastuzumab-therapy, we developed a mechanistic pharmacokinetic (PK) model to predict within-tumor exposure of trastuzumab/T-DM1. …”
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    Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier
  14. 30174
    “…The findings uncovered the in-depth structural mechanisms underpinning dual-targeting towards T315I BCR-ABL1 to overcome its drug resistance and will offer guidance for the rational design of next generations of BCR-ABL1 modulators and future combinatory therapeutic regimens.…”
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    Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1
  15. 30175
    “…The economic viability of CO(2) reactors is contingent on the selectivity of the CO(2) reduction reaction and the rate of product formation. For this, the rational design of electrolyzers also has a substantial impact on the figures of merit (current density, faradaic efficiency, cell durability). …”
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    The inchoate horizon of electrolyzer designs, membranes and catalysts towards highly efficient electrochemical reduction of CO(2) to formic acid
  16. 30176
    “…CONCLUSION: Since this is the first study to report on genetic diversity of C-terminal PfKAHRP interaction domain and the repeat motifs from clinical samples in Saudi Arabia, it will contribute towards the rational design of antiadhesion drug therapies for P. falciparum malaria.…”
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    Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Plasmodium falciparum Clinical Samples from Saudi Arabia
  17. 30177
    “…Such knowledge is fundamental for rational and efficient strain and process development.…”
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    Heterologous Lactate Synthesis in Synechocystis sp. Strain PCC 6803 Causes a Growth Condition-Dependent Carbon Sink Effect
  18. 30178
    “…This work not only unveiled the S2-specific nAbs but also discovered an immunodominant epitope in the S2 subunit that can be rationally designed as the broad-spectrum vaccine against the SARS-like coronaviruses.…”
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    Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion
  19. 30179
    por Liu, Xiaojing, Zhao, Yajiao, Hao, Feng
    Publicado 2022
    “…Screening high nitrogen (N) efficiency crops is crucial to utilize resources rationally and reduce N losses. In this research, the biomass, morphological and N-related parameters of 28 alfalfa (Medicago sativa L.) cultivars were assessed at seedling stage. …”
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    Development of nitrogen efficiency screening system in alfalfa (Medicago sativa L.) and analysis of alfalfa nitrogen efficiency types
  20. 30180
    “…Taking the influencing factors as the predictor variables and the hospitalization cost as the target variable, the exhaustive Chi-squared automatic interaction detector (E-CHAID) algorithm was used to form the costs grouping, and the payment standard of the hospitalization cost for each group was determined. The rationality of cost grouping was evaluated by coefficient of variation (CV) and Kruskal–Wallis H test. …”
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    Study of Hospitalization Costs in Patients with Cerebral Ischemia Based on E-CHAID Algorithm
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