“…The data might be useful for rational antimicrobial usage against Salmonella 4,[5],12:i:- infections, risk management, and public health strategies in Guizhou.…”
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“…Several inhibitors of LKB1 downstream proteins, such as mTOR, MEK, ERK and SRK/FAK, resulted specifically active on LKB1-mutated preclinical models and, being molecules already in clinical experimentation, could be soon proposed as a specific therapy for these patients. In particular, the rational use in combination of these inhibitors represents a very promising strategy to prevent the activation of collateral pathways and possibly avoid the potential emergence of resistance to these drugs. …”
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“…The current study provides the rational insight into the design of nanohierarchitectures and how microstructure affects different properties of the material upon doping.…”
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“…Twenty-four lactating Chinese Holstein dairy cattle were assigned to either the SBM group [the basal total mixed ration (TMR) diet containing 5.77% SBM] or the FSBM group (the experimental TMR diet containing 5.55% FSBM), in a completely randomized design. …”
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“…The suggested structure−activity relationship (SAR) can provide insight into how coumarin hybrids can be rationally improved against multidrug-resistant bacteria. …”
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“…Obviously, laboratory identification and ASTs are much needed along with surveillance programmes in hospitals. Together with rational use of antibiotics these measures will help to slow down the progress of the deadly AMR pandemic.…”
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“…We systematically addressed the role of the N terminus by generating a series of mutants in which N-terminal residues methionine (Met1) and arginine (Arg2) were either deleted, extended or substituted with other rationally selected amino acids. Each mutant was subsequently analyzed by NMR spectroscopy or fluorescence thermal shift assays for its structural or thermal stability; we found that N-terminal perturbations indeed affected the overall protein structure and that the solution structure better reflects the conformation of PRC1 under solution conditions. …”
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“…Our results show, for the first time, a complete conservation study of gp41/gp36 per variant in the largest panel of HIV variants analyzed to date, providing useful information for a more rational design of drugs, vaccines, and molecular detection tests targeting the HIV transmembrane glycoprotein.…”
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“…OBJECTIVES: This report aims to help develop more effective rational treatment strategies for Severe Protein Energy Malnutrition marasmus type, confirmed Covid-19 and Carcinoma Cervical on Chemotherapy. …”
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“…METHODS: White growing male Wistar rats for 28 days were on semisynthetic casein rations (RCC), with different content of calcium and vitamin D: group 1 - control RCC (physiological norm of calcium and vitamin D); group 2 - RCC without calcium + 2 norms of vitamin D; group 3 - RCC with two rates of calcium (carbonate) and two rates of vitamin D; group 4 - RCC with two rates of calcium (alginate) and two rates of vitamin D and group 5 - RCC with three levels of vitamin D. …”
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“…Each SNF (Corn Soy Blend Plus, Corn Soy Whey Blend, Super Cereal Plus with Amylase, and Ready to Use Supplementary Food) was provided to caregivers in 14-day isocaloric rations for 12 weeks or until reaching an outcome. …”
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“…It is challenging to identify the species in morphology, and the lack of molecular biology information hinders the identification and rational utilization of the germplasm of this genus. …”
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“…The study consisted of two experiments conducted as randomized complete block designs using bahiagrass hay or a high-concentrate mixed ration as basal substrates. In the first experiment (Exp. 1), a batch culture was performed with increasing doses of OA, UA, or MA. …”
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“…Supplemented amino acids (AA) were mixed with the premix and added to the total mixed ration during the experiment. DMI (p < 0.001) and energy-corrected milk (ECM, p = 0.04) were higher for cows that were fed RPML–RPML than other cows. …”
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“…These findings along with the biochemical characterization of novel fungal LPMO9s have implications on our understanding of their concerted action, allowing rational engineering of fungal strains for biotechnological applications such as plant biomass degradation. …”
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“…All these experimental observations can be rationalized through simulations, which show that the assemblies of embedded dipolar groups introduce a potential discontinuity within the monolayer, shifting the energy levels above and below the dipoles relative to each other. …”
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“…This work presents new understanding about the defect engineering mechanism in g-C(3)N(4) semiconductors, and thus paves the way for rational design of effective polymeric photocatalysts through advanced defective functional group engineering techniques evolving CO(2) as the industrial carrier gas.…”
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“…This study aimed to investigate the effects of two brown Icelandic seaweed samples (Ascophyllum nodosum and Fucus vesiculosus) on in vitro methane production, nutrient degradation, and microbiota composition. A total mixed ration (TMR) was incubated alone as control or together with each seaweed at two inclusion levels (2.5 and 5.0% on a dry matter basis) in a long-term rumen simulation technique (Rusitec) experiment. …”
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“…This study may be useful in validating the rationality of daily consumption of decoction of A. catechu and also its use in traditional medicine system. …”
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“…The current study thus rationalized to address how salt stress affected the growth, biochemical properties, antioxidant capacity, endogenous indole-3-acetic acid (IAA), and the ionic status of maize associated with endophytic fungus (Stemphylium lycopersici). …”
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