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30261“…This study uses a computational modeling approach to test the hypothesis that custom hypothetical cells can be rationally designed to restore a healthy phenotype when coupled to human heart failure (HF) cardiomyocytes. …”
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30262por Stang, Frida Lindskov, Bjerregaard, Rikke, Müller, Cecilia Elisabeth, Ergon, Åshild, Halling, Magnus, Thorringer, Nana Wentzel, Kidane, Alemayehu, Jensen, Rasmus Bovbjerg“…Carbohydrates in forages constitute an important part of the feed ration for all horses. The aim of the present study was to investigate the effect of harvest time on carbohydrate composition and digestion of various grass species. …”
Publicado 2022
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30263“…Data obtained in this work will support the rational design of optimized β-lactam-based combination therapies against resistant P. aeruginosa infections. …”
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30264por Valcek, Adam, Philippe, Chantal, Whiteway, Clémence, Robino, Etienne, Nesporova, Kristina, Bové, Mona, Coenye, Tom, De Pooter, Tim, De Coster, Wouter, Strazisar, Mojca, Van der Henst, Charles“…While formerly established strains successfully generated a strong base of knowledge in the A. baumannii field and beyond, our study shows that a rational choice of strain, related to a specific biological question, should be taken into consideration. …”
Publicado 2022
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30265por Zhuang, Wei, He, Tao, Jia, Bei-Bei, Wang, Zhi-Zhou, Zhang, Lan, Dong, Xian-Zhe, Xi, Sheng-Yan“…Aim of the study: We aimed i) to provide an overview of the TCM formulations affecting the pharmacology of digoxin and their mechanisms of action and ii) to provide a theoretical reference for the safe and rational use of digoxin in combination with TCM in clinical practice and to avoid ADRs. …”
Publicado 2023
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30266“…The TR4c-TR5 in Kwak TIRADS and TR4b-TR5 in C TIRADS had a rational RABM (RABM < 1). The modified Kwak TIRADS had higher sensitivity, a positive predictive value, a negative predictive value, lower specificity, an unnecessary biopsy rate, and a missed malignancy rate compared with the original Kwak TIRADS (94.1% vs. 42.6%, 59.4% vs. 44.6%, 89.9% vs. 52.8%, 45.0% vs. 54.9%, 40.6% vs. 55.4%, and 10.1% vs. 47.1%, respectively, P < 0.05 for all). …”
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30267por Lin, Xueyan, Ju, Lin, Cheng, Qianjin, Jiang, Yue, Hou, Qiuling, Hu, Zhiyong, Wang, Yun, Wang, Zhonghua“…The experiment was carried out in two various periods, namely, X and Y for groups S and B, respectively. The rations were fed with concentrate-to-roughage ratios of 3:7 and 5:5, respectively. …”
Publicado 2023
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30268por Rubín, Javier, Arauzo, Ana, Bartolomé, Elena, Sedona, Francesco, Rancan, Marzio, Armelao, Lidia, Luzón, Javier, Guidi, Tatiana, Garlatti, Elena, Wilhelm, Fabrice, Rogalev, Andrei, Amann, Andreas, Spagna, Stefano, Bartolomé, Juan, Bartolomé, Fernando“…The magnetic results can be rationalized within a model, including the cluster anisotropy, in which the {Cr(10)} wheel is formed by two semiwheels, each with four Cr(3+) spins FM coupled (J(FM)/k(B) = 2.0 K), separated by two Cr(3+) ions AF coupled asymmetrically (J(23)/k(B) = J(78)/k(B) = −2.0 K; J(34)/k(B) = J(89)/k(B) = −0.25 K). …”
Publicado 2022
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30269por Mohammad, Shamim, Wang, Yuxia, Cordero, John, Watson, Christopher, Molestina, Robert, Rashid, Sujatha, Bradford, Rebecca“…We generated highly specific monoclonal antibodies (mAbs) against rationally designed SARS-CoV-2 spike protein. Matched pair mAbs were selected by epitope mapping and employed as antigen capture reagents by spotting onto a nitrocellulose membrane and as detector reagents by conjugation with colloidal gold nanoparticles. …”
Publicado 2023
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30270“…Moreover, for the prevalence, a 1% change in open water, deciduous forest, or mixed forest is worth a 382-, 230-, or 650-USD increase in household income. Furthermore, a rational development intensity is also critical to reduce the risk of the COVID-19 pandemic. …”
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30271por Peled, Y., Patel, J., Raanani, E., Segev, A., Matezki, S., Ram, E., Fardman, A., Beigel, R., Atari, N., Kliker, L., Elkader, B. Abd, Mandelboim, M., Afek, A.“…Our findings could assist in rationally focusing improvements for future vaccines and immunotherapeutic for SARS-CoV-2 and population-tailored vaccination strategy.…”
Publicado 2023
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30272por Krishnan, Anand, Kumar, Rakesh, Amarchand, Ritvik, Mohan, Anant, Kant, Ravi, Agarwal, Ankit, Kulshreshtha, Poorvi, Panda, Prasan Kumar, Bhadoria, Ajeet Singh, Agarwal, Neeraj, Biswas, Bijit, Nair, Rathish, Wig, Naveet, Malhotra, Rajesh, Bhatnagar, Sushma, Aggarwal, Richa, Soni, Kapil Dev, Madan, Nirupam, Trikha, Anjan, Tiwari, Pawan, Singh, Angel Rajan, Wyawahare, Mukta, Gunasekaran, Venugopalan, Sekar, Dineshbabu, Misra, Sanjeev, Bhardwaj, Pankaj, Goel, Akhil Dhanesh, Dutt, Naveen, Kumar, Deepak, Nagarkar, Nitin M., Galhotra, Abhiruchi, Jindal, Atul, Raj, Utsav, Behera, Ajoy, Siddiqui, Sabbah, Kokane, Arun, Joshi, Rajnish, Pakhare, Abhijit, Farooque, Farhan, Pawan, Sai, Deshmukh, Pradeep, Solanki, Ranjan, Rathod, Bharatsing, Dutta, Vibha, Mohapatra, Prasanta Raghab, Panigrahi, Manoj Kumar, Barik, Sadananda, Guleria, Randeep“…These results can be used to prioritize patients who are at increased risk of death and to rationalize therapy to reduce mortality due to COVID-19.…”
Publicado 2023
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30273por Lambisia, Arnold W, Makori, Timothy O, Mutunga, Martin, Cheruiyot, Robinson, Murunga, Nickson, Quick, Joshua, Githinji, George, Nokes, D James, Houldcroft, Charlotte J, Agoti, Charles N“…We recommend future comprehensive studies elucidating on HAdV-F genetic diversity and immunity for rational vaccine development.…”
Publicado 2023
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30274por Lu, Chunmei, Xu, Jie, Cao, Yang, Zhang, Ying, Liu, Xiaoyu, Wen, Haixia, Yan, Yan, Wang, Jiao, Cai, Minghui, Zhu, Hui“…It also promoted higher-order ability-set acquisition and allowed a rationalized formative evaluation system.…”
Publicado 2023
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30275por Ezeh, Christian Kelechi, Eze, Chibuzor Nwadibe, Dibua, Marie Esther Uju, Emencheta, Stephen Chijioke“…Hence it is imperative to develop programs to promote rational use of antimicrobial agents, infection prevention and control to reduce the incidence of antimicrobial resistance. …”
Publicado 2023
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30276“…Additionaly, encouraging the patients' attendance in SDM, reducing paternalistic and informed decision-making during prescribing, improving patient medication compliance, and increasing the promotion and guidance of rational medication use for patients are essential to reduce polypharmacy in Chinese chronic disease patients.…”
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30277por Shi, Yafei, Qian, Di, Li, Yanhui, Chen, Wei, Bo, Mingming, Zhang, Mingyu, Shi, Jianglei, Jia, Bei, Dai, Yuanyuan, Li, Guohui“…The present study aimed to assess the cost-effectiveness of sintilimab + pemetrexed plus platinum vs. that of pemetrexed plus platinum alone as the first-line therapy for patients with nonsquamous NSCLC to inform clinically rational drug use and provide a basis for medical decision-making. …”
Publicado 2023
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30278por Garcia-Lopez, Jesus, Ahmad, Shiekh Tanveer, Li, Yiran, Gudenas, Brian, Kojic, Marija, Manz, Friedrik, Jonchere, Barbara, Mayasundari, Anand, Pitre, Aaron, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Pfister, Stefan, Waszak, Sebastian, Bianski, Brandon, Tinkle, Christopher, Orr, Brent, Rankovic, Zoran, Robinson, Giles, Wainwright, Brandon, Kutscher, Lena, Lin, Hong, Northcott, Paul“…These results provide essential mechanistic insight into the molecular and cellular basis of SHH-MB predisposition driven by ELP1 LOF and nominate therapies that overcome p53 pathway inhibition as a rational treatment option for affected children.…”
Publicado 2023
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30279por Liu, Ilon, Cruzeiro, Gustavo Alencastro Veiga, Bjerke, Lynn, Rogers, Rebecca, Grabovska, Yura, Beck, Alexander, Mackay, Alan, Barron, Tara, Hack, Olivia, Quezada, Michael, Molinari, Valeria, Shaw, McKenzie, Temelso, Sara, Raynaud, Florence, Ruddle, Ruth, Panditharatna, Eshini, Englinger, Bernhard, Mire, Hafsa, Jiang, Li, Silva, Andrezza Do Nascimento, LaBelle, Jenna, Haase, Rebecca, Rozowsky, Jacob, Nguyen, Quang-De, Pericoli, Giulia, Madlener, Sibylle, Mayr, Lisa, Dorfer, Christian, Geyeregger, Rene, Ricken, Gerda, Ligon, Keith, Alexandrescu, Sanda, Agnihotri, Sameer, Eisenstat, David, Carceller, Fernando, Stapleton, Simon, Bleil, Cristina, Mastronuzzi, Angela, Cole, Kristina, Waanders, Angela, Carcaboso, Angel Montero, Schüller, Ulrich, Vinci, Maria, Hargrave, Darren, Haberler, Christine, Slavc, Irene, Gojo, Johannes, Monje, Michelle, Jones, Chris, Filbin, Mariella“…In sum, we reveal CDK6 inhibition as a rationally informed and clinically actionable therapeutic avenue that selectively perturbs the unique interneuronal lineage in DHG-H3G34, paving the way for rapid clinical translation.…”
Publicado 2023
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30280por Mambula, Grace, Nanjebe, Deborah, Munene, Aurelia, Guindo, Ousmane, Salifou, Aichatou, Mamaty, Abdoul-Aziz, Rattigan, Susan, Ellis, Sally, Khavessian, Nathalie, van der Pluijm, Rob W, Marquer, Caroline, Adehossi, Irene Aicha, Langendorf, Céline“…BACKGROUND: Antibiotic resistance is a significant public health problem and is responsible for high mortality in children and new-borns. Strengthening the rational use of antibiotics and improving the quality and access to existing antibiotics are important factors in the fight against antibiotic resistance. …”
Publicado 2023
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