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  1. 30281
    por Dixon-Douglas, Julia, Loi, Sherene
    Publicado 2023
    “…Similarly, the potential benefit of other adjuvant therapies in patients with poor response to neoadjuvant ICI with chemotherapy, including capecitabine and olaparib with or without ICI, is also unknown, but is rational on the basis of administering a non-cross-resistant anti-tumour agent. …”
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    Immunotherapy in Early-Stage Triple-Negative Breast Cancer: Where Are We Now and Where Are We Headed?
  2. 30282
    por Zhang, Yue, Lin, Xing, Li, Xing, Han, Youli
    Publicado 2023
    “…BACKGROUND: Rational allocation of human resources for health is crucial for ensuring public welfare and equitable access to health services. …”
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    The impacts of altruism levels on the job preferences of medical students: a cross-sectional study in China
  3. 30283
    “…Future studies might reveal if depression of milk yield and feed intake can be avoided if iodoform is continuously administered by mixing it into a total mixed ration.…”
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    Enteric methane emission of dairy cows supplemented with iodoform in a dose–response study
  4. 30284
    “…Furthermore, the high-resolution structures of SARS-CoV-2 3CLpro in complex with C2–C5a will facilitate future rational optimization of our novel broad-spectrum active-site-directed 3C-like protease inhibitors.…”
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    A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
  5. 30285
    “…After weaning, both groups were fed the same mixed ration ad libitum until slaughter at 8 months. RESULTS: Animals of the 20% feeding group had a significantly higher body weight, but the proportion of animals having a corpus luteum at the time of slaughter was not different between groups, suggesting a similar onset of puberty. …”
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    Early milk-feeding regimes in calves exert long-term effects on the development of ovarian granulosa cells
  6. 30286
    “…A more comprehensive understanding of the dysfunctional cellular mechanisms will help rationalize the design of potent and selective therapies for C9orf72-ALS. …”
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    A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
  7. 30287
    “…Through in silico and rational mutagenesis on the scFV domain, the 74bbz CAR was functionally optimized for superior antigen binding affinity, proliferative signaling, and cytotoxic activity against MCL cells in vitro and in vivo. …”
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    A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
  8. 30288
    “…These findings should facilitate the rational choice of suitable parents for producing crossbred chickens. …”
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    The mRNA-lncRNA landscape of multiple tissues uncovers key regulators and molecular pathways that underlie heterosis for feed intake and efficiency in laying chickens
  9. 30289
    “…Screening a small semi-rational mutant library directly in M. extorquens yielded the F35L variant which showed a drastic product level increase for mesaconic acid (6.4-fold) and 2-methylsuccinic acid (4.4-fold) compared to the unaltered YciA enzyme. …”
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    Engineering of thioesterase YciA from Haemophilus influenzae for production of carboxylic acids
  10. 30290
    “…This novel finding lays a substantial experimental groundwork for guiding clinically rational antimicrobial therapy and advancing the exploration of relevant pathogenic mechanisms pertaining to Vagococcus fluvialis infections.…”
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    A case of Vagococcus fluvialis isolated from the bile of a patient with calculous cholecystitis
  11. 30291
    “…The present study explored the effects of different associated bryophyte species on the yield and quality of D. nobile to clarify the dominant bryophyte species associated with D. nobile and to provide a scientific basis for the rational cultivation and quality evaluation of D. nobile. …”
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    Species of associated bryophytes and their effects on the yield and quality of Dendrobium nobile
  12. 30292
    “…The feeling of shame regarding the miscarriage was the main driver for women to get pregnant again (Odd ration [OR] 2.98; 95% confidence interval (CI) 1.31–6.82; p = 0.01). …”
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    Navigating miscarriage in Jordan: understanding emotional responses and coping strategies
  13. 30293
    “…It also assumes target populations to embody an “ascetic subject of compliance”—the idea of a patient who strives to comply diligently with professional medical advice, logically and rationally adopting any recommended lifestyle changes. …”
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    Advancing the communication of genetic risk for cardiometabolic diseases: a critical interpretive synthesis
  14. 30294
    “…The use of low-skilled care assistants has been suggested as a cost-saving human resource for health strategy that can significantly reduce the risks of rationed, delayed, or missed care. However, the characterisation, role assignment, regulation, and clinical governance mechanisms for unlicensed assistive workforce remain unclear or inconsistent. …”
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    Characterising support and care assistants in formal hospital settings: a scoping review
  15. 30295
    “…Appropriateness of the diagnosis and the rationality of antibiotic and other drug use were measured as per the Integrated Management of Childhood Illness guideline. …”
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    Beyond the regulatory radar: knowledge and practices of rural medical practitioners in Bangladesh
  16. 30296
    “…Multinuclear platinum compounds were rationally designed to bind to DNA in a different manner from that of cisplatin and its mononuclear analogues. …”
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    A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts
  17. 30297
    “…Patients who are keen on non-intervention can safely choose expectant management with intensive maternal and fetal monitoring; however, it is rational to choose induction to prevent possible neonatal morbidity and stillbirth. …”
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    Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)
  18. 30298
    “…The combined use of the two biomarkers can predict a subsequent hospitalization of febrile patients. The rational use of these two molecules could lead to several advantages, such as faster diagnosis, more accurate risk stratification, and optimization of the treatment, with consequent benefit to the patient and considerably reduced costs.…”
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    Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score
  19. 30299
    “…Based on this background, we hypothesized that targeting the HGF/MET signaling pathway is a rational approach to myeloma therapy and that myeloma cells would be sensitive to amuvatinib. …”
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    Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines
  20. 30300
    “…There was also high coherence between current and desired research on Rational selection and use of medicines (r = 0.71, P <0.05, R(2) = 0.51), Pricing/affordability (r = 0.82, P <0.01, R(2) = 0.67), and Sustainable financing (r = 0.76, P <0.01, R(2) = 0.58). …”
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    Stakeholders’ perspectives on access-to-medicines policy and research priorities in Latin America and the Caribbean: face-to-face and web-based interviews
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