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  1. 30321
    “…OBJECTIVE: This study was done to evaluate the effect of sodium stearoyl-2-lactylate (SSL) supplementation in a total mixed ration (TMR) on the lactation performance, blood parameters, and economic efficacy of mid-lactation Holstein cows. …”
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    Effect of sodium stearoyl-2-lactylate supplementation on lactation performance, blood-biochemical profile, and economic efficacy of mid-lactation Holstein cows
  2. 30322
    “…Our data provide a roadmap for the rational deployment of oncogenic signaling inhibitors in molecularly-defined subsets of DLBCL.…”
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    A Multiprotein Supercomplex Controlling Oncogenic Signaling in Lymphoma
  3. 30323
    “…Therefore, continued surveillance on uropathogens prevalence and resistance rates is needed to ensure appropriate recommendations for the empirical treatment, develop rational prescription programs and make policy decisions.…”
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    Common uropathogens and their antibiotic susceptibility pattern among diabetic patients
  4. 30324
    por Terry, Mary Beth, Liao, Yuyan, Kast, Karin, Antoniou, Antonis C, McDonald, Jasmine A, Mooij, Thea M, Engel, Christoph, Nogues, Catherine, Buecher, Bruno, Mari, Véronique, Moretta-Serra, Jessica, Gladieff, Laurence, Luporsi, Elisabeth, Barrowdale, Daniel, Frost, Debra, Henderson, Alex, Brewer, Carole, Evans, D Gareth, Eccles, Diana, Cook, Jackie, Ong, Kai-ren, Izatt, Louise, Ahmed, Munaza, Morrison, Patrick J, Dommering, Charlotte J, Oosterwijk, Jan C, Ausems, Margreet G E M, Kriege, Mieke, Buys, Saundra S, Andrulis, Irene L, John, Esther M, Daly, Mary, Friedlander, Michael, McLachlan, Sue Anne, Osorio, Ana, Caldes, Trinidad, Jakubowska, Anna, Simard, Jacques, Singer, Christian F, Tan, Yen, Olah, Edith, Navratilova, Marie, Foretova, Lenka, Gerdes, Anne-Marie, Roos-Blom, Marie-José, Arver, Brita, Olsson, Håkan, Schmutzler, Rita K, Hopper, John L, van Leeuwen, Flora E, Goldgar, David, Milne, Roger L, Easton, Douglas F, Rookus, Matti A, Andrieu, Nadine
    Publicado 2019
    “…Relative to being nulliparous, uniparous BRCA1 mutation carriers were at increased BC risk in the prospective analysis (prospective hazard ration [HR(p)] = 1.69, 95% CI = 1.09 to 2.62). For BRCA2 mutation carriers, being parous was associated with a 30% increase in BC risk (HR(c) = 1.33, 95% CI = 1.05 to 1.69), and there was no apparent decrease in risk associated with multiparity except for having at least 4 FTPs vs. 1 FTP (HR(c) = 0.72, 95% CI = 0.54 to 0.98). …”
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    The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations
  5. 30325
    “…When combined with a rationally designed CAR construct, EC17 CAM was shown to trigger CAR-modified T cell activation and cytolytic activity with a low FR threshold against tumor targets. …”
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    Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies
  6. 30326
    “…Pharmacological inhibition of the WNT/β-catenin pathway may be a rational combination to sensitize CRCs to cibisatamab. …”
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    CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
  7. 30327
    “…The purpose of this design is to improve the potency and enhance the toxicity profile of the parent peptides. Methods: Rational design was used to hybridize two antimicrobial peptides, in which two helical parts from the bovine analog BMAP-27, and the human cathelicidin LL-37 were used to generate a novel peptide (B1). …”
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    Design and characterization of a new hybrid peptide from LL-37 and BMAP-27
  8. 30328
    “…ENT’s preclinical in vivo efficacy makes ENT a rational drug candidate in a phase II clinical trial for eRMS. …”
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    Preclinical rationale for entinostat in embryonal rhabdomyosarcoma
  9. 30329
    “…These findings provide insight into diet-induced remission of gastrointestinal disease and could help guide the rational design of more effective therapeutic diets. …”
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    Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids
  10. 30330
    “…The concept “time-to-reach target calprotectin level” rationalizes the indefinite term “response to treatment” and is well suited for studying treatment effectiveness in real-world practices.…”
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    Time-to-reach Target Calprotectin Level in Newly Diagnosed Patients With Inflammatory Bowel Disease
  11. 30331
    “…This mechanism expands on the previously established mechanisms by which LMP1 regulates miR-155 and FOXO3a and may represent both rational therapeutic targets and biomarkers for EBV+ B cell lymphomas.…”
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    Epstein-Barr Virus Latent Membrane Protein 1 Regulates Host B Cell MicroRNA-155 and Its Target FOXO3a via PI3K p110α Activation
  12. 30332
    “…Health programs focused on risk populations appear as a rational way to control syphilis spread, which is a rising problem in Brazil and in other several countries.…”
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    Prevalence of syphilis in female sex workers in three countryside cities of the state of Pará, Brazilian Amazon
  13. 30333
    “…This study will be helpful for the rational design of clinical trials for NQ.…”
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    The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents
  14. 30334
    “…Neoadjuvant pharmacodynamic studies allow for a rational approach to the decisions regarding which targeted therapies should progress to phase II/III trials. …”
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    Pharmacodynamics effects of CDK4/6 inhibitor LEE011 (ribociclib) in high-risk, localised prostate cancer: a study protocol for a randomised controlled phase II trial (LEEP study: LEE011 in high-risk, localised Prostate cancer)
  15. 30335
    “…Results from this survey may help to inform policymakers in rational planning for future health system development related to capacity building and regulation of human resources for health. …”
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    Assessment of dual practice among physicians in Cambodia
  16. 30336
    “…It is necessary to develop a rational approach of chromatography coupled with activity detection for quality assessment of herbal medicines. …”
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    “Quantity-effect” research strategy for comparison of antioxidant activity and quality of Rehmanniae Radix and Rehmannia Radix Praeparata by on-line HPLC-UV-ABTS assay
  17. 30337
    “…SETTING AND PARTICIPANTS: A random sample of 10 000 outpatient visits was selected between January and April 2018 from a national database for monitoring rational use of drugs, which included data from 194 secondary and tertiary hospitals in China. …”
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    Validation of an algorithm to evaluate the appropriateness of outpatient antibiotic prescribing using big data of Chinese diagnosis text
  18. 30338
    “…This may be attributed to a high risk of disease as veal calves are often purchased from numerous dairy herds, exposed to stress related to the transport and commingling of new animals, and fed a new ration. In this study, we used national register data to characterize the use of antimicrobials registered for large Danish veal calf and young bull producing herds in 2014. …”
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    A register-based study of the antimicrobial usage in Danish veal calves and young bulls
  19. 30339
    “…For example, an understanding of how the sequence features of these regions relate to dynamic properties in multi-domain proteins would aid in the rational design of linkers in therapeutic fusion proteins. …”
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    Investigation of sequence features of hinge-bending regions in proteins with domain movements using kernel logistic regression
  20. 30340
    “…Studies suggest that estimates of malaria are useful to rationalize interventions and track their impact. Hence, a national study was launched to estimate burden of malaria in India in 2015. …”
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    Surveillance based estimation of burden of malaria in India, 2015–2016
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