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  1. 30341
    “…The aim of this study was to analyse adherence using the medication possession ration (MPR) and its relation to virological outcomes in a large multi-centre hospital outpatient population, and guide development of an evidence-based threshold for optimal adherence. …”
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    Adherence in chronic hepatitis B: associations between medication possession ratio and adverse viral outcomes
  2. 30342
    “…Based on the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases, differential analysis showed that the liver was the site where RPA exerted a significant effect, which confirmed the rationality of “meridian tropism” in the theory in TCM. …”
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    Transcriptomics- and metabolomics-based integration analyses revealed the potential pharmacological effects and functional pattern of in vivo Radix Paeoniae Alba administration
  3. 30343
    “…Thorough understanding of the conservation and variation of prophage genomic characteristics will facilitate their rational design and use as tools for bacterial strain construction, vector development and as anti-bacterial agents.…”
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    Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica
  4. 30344
    “…The relationship between active site segments and the mode-of-action of these NcLPMOs was rationalized by a structure-based phylogenetic analysis of fungal AA9 LPMOs. …”
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    Configuration of active site segments in lytic polysaccharide monooxygenases steers oxidative xyloglucan degradation
  5. 30345
    “…Meanwhile, recent efforts on rational metabolic engineering approaches to increase butanol production in Clostridium strain are quite limited. …”
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    Development of optimal steam explosion pretreatment and highly effective cell factory for bioconversion of grain vinegar residue to butanol
  6. 30346
    “…CONCLUSIONS: Whilst impairments in decision-making capacity may exist, most patients with a severe mental disorder, such as schizophrenia or bipolar disorder are able to make rational decisions about their healthcare. Best practice strategies should incorporate interventions to help mentally ill patients grow into the voluntary and safe use of medications.…”
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    A meta-review of literature reviews assessing the capacity of patients with severe mental disorders to make decisions about their healthcare
  7. 30347
    “…CONCLUSIONS: Through the implantation of information technology, the local transformation of the site, the rational allocation of medical teams and the planned distribution of protective equipment, in a short period of time, individual medical institutions can set up a safe FUO emergency department to provide 24-hour screening and detention services. …”
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    Establishing a standardized FUO emergency department: design and practice in dealing with COVID-19
  8. 30348
    “…Specific and targeted interventions to address AMR in Bangladesh should include educational messages on the rational use of antibiotics and how they work, targeting all types of healthcare providers. …”
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    What contributes to inappropriate antibiotic dispensing among qualified and unqualified healthcare providers in Bangladesh? A qualitative study
  9. 30349
    “…METHODS: Functionally, both drugs induce cell cycle arrest, intracellular reactive oxygen species (iROS) production, and apoptosis. We rationalized that an overlapping of the drug activities should offer an enhanced anticancer effect, either through vertical inhibition of the Src-STAT3 axis or horizontal suppression of multiple pathways. …”
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    Transcriptomic insight into salinomycin mechanisms in breast cancer cell lines: synergistic effects with dasatinib and induction of estrogen receptor β
  10. 30350
    por St.Pierre, Michael, Nyce, James M.
    Publicado 2020
    “…Novices conceptualized decision making as a rational, linear process whereas experts added to this understanding of tacit knowledge and intuitive decision making. …”
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    How novice and expert anaesthetists understand expertise in anaesthesia: a qualitative study
  11. 30351
    “…CONCLUSION: The discrepancy of genotype and phenotype resistance has significant consequences for clinical bacteriology, precision in diagnosis, the prudent selection of antimicrobials, and rational prescribing. Heterogeneous phenotypes of antimicrobial susceptibility testing should be taken seriously to avoid inappropriate diagnostic and therapeutic decisions.…”
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    Genotypic to Phenotypic Resistance Discrepancies Identified Involving β-Lactamase Genes, blaKPC, blaIMP, blaNDM-1, and blaVIM in Uropathogenic Klebsiella pneumoniae
  12. 30352
    “…CONCLUSIONS: Hill-based indices provide a rational framework for analysis of dissimilarity between microbial community samples. …”
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    Hill-based dissimilarity indices and null models for analysis of microbial community assembly
  13. 30353
    “…RESULTS: Healthcare managers addressed frequent stock-outs of malaria programme drugs and supplies from the National Malaria Control Programme and delayed reimbursement from the NHIS, by instituting co-payment, rationing and prescribing drugs for women to buy from private pharmacies. …”
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    Managing intermittent preventive treatment of malaria in pregnancy challenges: an ethnographic study of two Ghanaian administrative regions
  14. 30354
    “…This study aimed to formulate a rational dosage strategy and review the preceding recommended dosage based on PK/PD modeling and Establish Clinical breakpoint of ceftiofur against Actinobacillus pleuropneumoniae based on the pharmacodynamic-pharmacokinetic cutoff. …”
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    Optimal regimens based on PK/PD cutoff evaluation of ceftiofur against Actinobacillus pleuropneumoniae in swine
  15. 30355
    “…Third, data analytics pipelines offer new capacity to generate new types of TMS-inspired medicines that are rationally-designed based on integrated knowledge across cultures, and also provide an evaluative framework against which to test claims of fidelity and efficacy to TMS made for nutraceuticals.…”
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    Medicine in motion: Opportunities, challenges and data analytics-based solutions for traditional medicine integration into western medical practice
  16. 30356
    “…CONCLUSIONS: The high volume of CPTM usage is the typical feature in outpatient care of AURI pediatric patients in China. The rational and cost-effective use of CPTM and antibiotics still faces challenges. …”
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    Characteristics of prescriptions and costs for acute upper respiratory tract infections in Chinese outpatient pediatric patients: a nationwide cross-sectional study
  17. 30357
    “…OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has resulted in a marked increase in hospital usage, medical resource scarcity, and rationing of surgical procedures. This has created the need for strategies to triage surgical patients. …”
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    Vascular surgery triage during the coronavirus disease 2019 pandemic
  18. 30358
    “…This study is a further investigation of the triterpenoids in Liquidambaris Fructus and aims to identify their anti-breast cancer targets, meanwhile, to estimate the rationality of the traditional applications of Liquidambaris Fructus. …”
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    Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
  19. 30359
    “…In this regard, health authorities should provide training to enable the rational and correct use of facemask among healthcare workers.…”
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    Correct Use of Facemask Among Health Professionals in the Context of Coronavirus Disease (COVID-19)
  20. 30360
    “…RESULTS: After adjusting for covariates, AVI had the optimal ability of identifying MetS (AUC: 0.743 for male, 0.819 for female) and the strongest correlation with high-density lipoprotein cholesterol (HDL-C) (coe: − 0.227 for male, − 0.207 for female) and the highest odds rations (OR) with low HDL-C group (male: OR = 1.37, female: OR = 1.55). …”
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    Novel and traditional anthropometric indices for identifying metabolic syndrome in non-overweight/obese adults
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