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  1. 30381
    “…However, there are currently no established biomarkers to predict SCLC sensitivity or resistance to lurbinectedin or preclinical studies to guide rational combinations. METHODS: Drug sensitivity was assayed in proliferation assays and xenograft models. …”
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    SLFN11 biomarker status predicts response to lurbinectedin as a single agent and in combination with ATR inhibition in small cell lung cancer
  2. 30382
    “…The structures provide important insights, have broad implications for understanding the structural basis underlying enzyme activity, and can facilitate rational design of broad-spectrum anti-coronavirus ligands as new therapeutic agents.…”
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    Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
  3. 30383
    “…Ameliorating the TME is thus a rational strategy for PDAC therapy. The intratumoral application of oncolytic herpes simplex virus-1 (oHSV) upregulates pro-inflammatory macrophages and lymphocytes in TME, and enhances the responsiveness of PDAC to immunotherapy. …”
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    CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model
  4. 30384
    “…BACKGROUND: Drug dispensing aims to promote rational medicine use. However, in many countries, the work processes are still not well defined. …”
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    Perception of community pharmacists about the work process of drug dispensing: a cross-sectional survey study
  5. 30385
    “…The present topological characterization of this toxin-antitoxin complex constitutes an essential step toward the rational design of novel peptide-based antivenom therapies targeting snake venom myotoxins.…”
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    Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom
  6. 30386
    “…In this study, we successfully created three novel rice lines with high yield, superior quality and improved BPH resistance by rational molecular design. Our results demonstrate molecular design is a powerful strategy to improve multiple complex traits and will provide a reference for the future commercial rice improvement. …”
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    Creation of Elite Rice with High-Yield, Superior-Quality and High Resistance to Brown Planthopper Based on Molecular Design
  7. 30387
    “…OBJECTIVE: To identify main effects of preoperative pattern and global coronal malalignment (GCM) on postoperative coronal imbalance in degenerative lumbar scoliosis (DLS) patients and evaluate the rationality of the classification of coronal deformity based on preoperative GCM. …”
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    The classification of coronal deformity based on preoperative global coronal malalignment for adult spinal deformity is questionable
  8. 30388
    por Feng, Qipu, Xiong, Ying, Wang, Juexi, Feng, Li
    Publicado 2022
    “…In addition, we hope that more rationally designed multicenter RCTs that are not limited to short-term treatment outcomes will be conducted in the future.…”
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    Immunosuppressants or corticosteroids compared with supportive therapy: a systematic review and meta-analysis on the efficacy and safety for IgA nephropathy treatment
  9. 30389
    “…The results provide scientific information for the quality control of SGR and its rational applications in herbal medicines and functional foods. …”
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    Influence of different pretreatments and drying methods on the chemical compositions and bioactivities of Smilacis Glabrae Rhizoma
  10. 30390
    por Wang, Chang Yi, Hwang, Kao-Pin, Kuo, Hui-Kai, Peng, Wen-Jiun, Shen, Yea-Huei, Kuo, Be-Sheng, Huang, Juin-Hua, Liu, Hope, Ho, Yu-Hsin, Lin, Feng, Ding, Shuang, Liu, Zhi, Wu, Huan-Ting, Huang, Ching-Tai, Lee, Yuarn-Jang, Liu, Ming-Che, Yang, Yi-Ching, Lu, Po-Liang, Tsai, Hung-Chin, Lee, Chen-Hsiang, Shi, Zhi-Yuan, Liu, Chun-Eng, Liao, Chun-Hsing, Chang, Feng-Yee, Chen, Hsiang-Cheng, Wang, Fu-Der, Hou, Kuo-Liang, Cheng, Jennifer, Wang, Min-Sheng, Yang, Ya-Ting, Chiu, Han-Chen, Jiang, Ming-Han, Shih, Hao-Yu, Shen, Hsuan-Yu, Chang, Po-Yen, Lan, Yu-Rou, Chen, Chi-Tian, Lin, Yi-Ling, Liang, Jian-Jong, Liao, Chun-Che, Chou, Yu-Chi, Morris, Mary Kate, Hanson, Carl V., Guirakhoo, Farshad, Hellerstein, Michael, Yu, Hui-Jing, King, Chwan-Chuen, Kemp, Tracy, Heppner, D. Gray, Monath, Thomas P.
    Publicado 2022
    “…We report phase I/II trial results of UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein and rationally designed promiscuous peptides representing sarbecovirus conserved helper T cell and cytotoxic T lymphocyte epitopes on the nucleocapsid (N), membrane (M), and spike (S2) proteins. …”
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    A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants
  11. 30391
    “…Synthetic biology provides a rational engineering principle for the transcriptional optimisation of key enzymes and the artificial creation of cofactor regeneration systems without regulatory interference. …”
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    Bottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis
  12. 30392
    “…CONCLUSIONS: In this study, a hypothetical secretory model of cellulase protein in filamentous fungi was established on the basis of DEGs/DEPs and key genes identified from the omics analysis, which were of great guidance on the rational genetic engineering and/or breeding of filamentous fungi for improving cellulase production. …”
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    Integrative transcriptome and proteome analyses of Trichoderma longibrachiatum LC and its cellulase hyper-producing mutants generated by heavy ion mutagenesis reveal the key genes involved in cellulolytic enzymes regulation
  13. 30393
    “…The proposed decision support tool can assist in developing rational preprocedural testing policies.…”
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    Risk-based decision-making related to preprocedural coronavirus disease 2019 testing in the setting of GI endoscopy: management of risks, evidence, and behavioral health economics
  14. 30394
    “…Therefore, proper hygienic practices from dairy farms to fork and rational drug usage are recommended.…”
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    Epidemiology and Antimicrobial Susceptibility Pattern of E. coli O157:H7 Along Dairy Milk Supply Chain in Central Ethiopia
  15. 30395
    por MacDermid, Joy C., Walton, David M.
    Publicado 2022
    “…RESULTS: The ND10 requires respondents to make rational judgements about their neck-related body function and disability. …”
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    Development and validation of the ND10 to measure neck-related functional disability
  16. 30396
    “…However, the nexus between delusion and rational awareness and how this is related to body image acceptance and perception has yet to be examined in AN. …”
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    Distinguishing delusional beliefs from overvalued ideas in Anorexia Nervosa: An exploratory pilot study
  17. 30397
    “…Interactions of the key genes with specific anti-cancer drugs must be considered in the rational design of MNP drug delivery systems.…”
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    Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics
  18. 30398
    “…Finally, whole-plant rape silage (after 60 days) was included in a 10, 20, and 30% of DM dairy buffalo diet in the lactating buffalo ration. The results showed that silage pH did not change significantly during the ensiling process (p > 0.05); however, the silage achieved the optimal comprehensive sensory characteristic score from days 30 to 60. …”
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    Evaluating the Effect of Forage Rape (Brassica napus) Ensiling Kinetics on Degradability and Milk Performance as Non-conventional Forage for Dairy Buffalo
  19. 30399
    “…It is difficult for clinicians to manage unretractable ROC when conventional therapy yields no results. The rational and effective use of immunotherapy will contribute to the clinical benefit of these patients, especially in patients without approved immunotherapy biomarkers. …”
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    Successful secondary radical operation on unretractable metastatic platinum-sensitive recurrent ovarian cancer by immunotherapy: a case report
  20. 30400
    por Li, Yanling, Wu, Xiancong, Wang, Jihong
    Publicado 2022
    “…The results of the time-space interaction show that after 8 weeks of COVID-19, Internet search hot topics have become more stable, and Internet users’ information demand structure has become more rational. CONCLUSIONS: The Internet search cycle of the COVID-19 event is synchronized with the evolution cycle of the epidemic. …”
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    Netizens’ risk perception in new coronary pneumonia public health events: an analysis of spatiotemporal distribution and influencing factors
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