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  1. 30481
    por Bonhoeffer, K. F.
    Publicado 1948
    “…The theory leads to a rational view of the interrelations between threshold, rheobase, accomodafion, refractoriness, and rhythm. …”
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    ACTIVATION OF PASSIVE IRON AS A MODEL FOR THE EXCITATION OF NERVE
  2. 30482
    “…PURPOSE: Rational modification of promoter architecture is necessary for manipulation of transgene activity and requires accurate deciphering of regulatory control elements. …”
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    In vitro analysis of promoter activity in Müller cells
  3. 30483
    “…Transmission is via concentrate feed rations contaminated with infected meat and bone meal (MBM). …”
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    Experimental transmission of bovine spongiform encephalopathy to European red deer (Cervus elaphus elaphus)
  4. 30484
    “…Insight into the respective contribution of the agonistic receptors TRAIL-R1 and TRAIL-R2 to TRAIL-induced apoptosis may provide a rational approach to further optimize TRAIL-based therapy. …”
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    Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells
  5. 30485
    “…BACKGROUND: Prescribing antimalarial medicines based on parasite confirmed diagnosis of malaria is critical to rational drug use and optimal outcome of febrile illness. …”
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    Impact of training in clinical and microscopy diagnosis of childhood malaria on antimalarial drug prescription and health outcome at primary health care level in Tanzania: A randomized controlled trial
  6. 30486
    “…This paves the way for a better understanding of the bioprocess and a more rational process design.…”
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    Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations
  7. 30487
    “…Obesity and recovery from lymphopenia after five days were factors associated with death, as determined by multivariate logistic-regression analysis (obesity, odds ratio = 23.06; lymphocytopenia reversion, odds ration = 28.69). CONCLUSIONS: During the evaluation period in Shenyang, China, 2009 H1N1 influenza caused severe illness requiring hospitalization in 68 patients, 10 (14.7%) of which died. …”
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    Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China
  8. 30488
    “…The FhuA Δ1-160 channel embedded in liposomes can be advanced to a universal and compound independent release system which allows a size selective compound release through rationally re-engineered channels.…”
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    Molecular understanding of sterically controlled compound release through an engineered channel protein (FhuA)
  9. 30489
    “…The vaccine constitutes the core element of broad control programs against this ectoparasite, in which acquired immunity in cattle to Bm86 is combined with a rational use of acaricides. At present, the conventional vaccine scheme consists of three doses that should be administered at weeks 0, 4 and 7, followed by a booster every six months. …”
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    Two initial vaccinations with the Bm86-based Gavac(plus )vaccine against Rhipicephalus (Boophilus) microplus induce similar reproductive suppression to three initial vaccinations under production conditions
  10. 30490
    “…These data, confirming a relationship between primary metabolism and antibiotic production, could be used to increase antibiotic yield both by rational genetic engineering and fermentation processes improvement.…”
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    Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations
  11. 30491
    “…These results become a discriminative tool in the selection and elaboration of rational mutagenesis strategies for the protein. They can also be used to predict if a given nsSNP, identified, for instance, in a genomic-scale analysis, can have a functional implication for a particular protein and which nsSNPs are most likely to be functionally silent for a protein. …”
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    Mutagenesis Objective Search and Selection Tool (MOSST): an algorithm to predict structure-function related mutations in proteins
  12. 30492
    “…Therefore, increasing the antioxidant capacity of the mitochondrial compartment could be a rational therapeutic approach for invasive breast cancer. …”
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    Mitochondrial targeted catalase suppresses invasive breast cancer in mice
  13. 30493
    “…There is also a need to improve workplaces hygiene and to rationalize work hours to minimize health risks. Since smoking was an important confounding factor that supplemented most of the actual occupational exposure, a study based on non-smoker subjects is needed to separate out the effects of smoking and other confounding factors that may obscure measurements of actual extent of occupational exposure.…”
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    Biological Monitoring of Blood Naphthalene Levels as a Marker of Occupational Exposure to PAHs among Auto-Mechanics and Spray Painters in Rawalpindi
  14. 30494
    “…Problem solving therapy aims to help clients solve interpersonal problems positively and rationally, thereby improving social functioning and reducing distress. …”
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    Psycho-education with problem solving (PEPS) therapy for adults with personality disorder: A pragmatic multi-site community-based randomised clinical trial
  15. 30495
    “…RESULTS: Doctors reporting more Avocation/Leisure activities tended to be women, to have older children, to be less surface-rational, more extravert, more open to experience, less agreeable, and to fantasize more. …”
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    Vocation and avocation: leisure activities correlate with professional engagement, but not burnout, in a cross-sectional survey of UK doctors
  16. 30496
    “…Haplotypes SFTPA1 6A(2 )(P = 0.0009, odds ration (OR) = 0.78), SFTPA2 1A(0 )(P = 0.002, OR = 0.79), SFTPA1-SFTPA2 6A(2)-1A(0 )(P = 0.0005, OR = 0.77), and SFTPD-SFTPA1-SFTPA2 C-6A(2)-1A(0 )(P = 0.00001, OR = 0.62) were underrepresented in patients, whereas haplotypes SFTPA2 1A(10 )(P = 0.00007, OR = 6.58) and SFTPA1-SFTPA2 6A(3)-1A (P = 0.0007, OR = 3.92) were overrepresented. …”
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    Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study
  17. 30497
    “…An empirical model could rationalize FGF - F(D )selection during wash-in. METHODS: During model derivation, 50 ASA PS I-II patients received desflurane in O(2 )with an ADU(® )anesthesia machine with a random combination of a fixed FGF - F(D )setting. …”
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    Mathematical method to build an empirical model for inhaled anesthetic agent wash-in
  18. 30498
    “…BACKGROUND: Use of diagnostics in integrated community case management (iCCM) of fever is recognized as an important step in improving rational use of drugs and quality of care for febrile under-five children. …”
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    Access, acceptability and utilization of community health workers using diagnostics for case management of fever in Ugandan children: a cross-sectional study
  19. 30499
    “…Adding RUSF to a package of monthly household food rations for households containing a child assigned to the intervention group did not result in a reduction in cumulative incidence of wasting (incidence risk ratio: 0.86; 95% CI: 0.67, 1.11; p = 0.25). …”
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    The Effect of Adding Ready-to-Use Supplementary Food to a General Food Distribution on Child Nutritional Status and Morbidity: A Cluster-Randomized Controlled Trial
  20. 30500
    “…In conclusion, honokiol treatment could potentially be a rational therapeutic strategy for breast carcinoma.…”
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    Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis
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