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  1. 30641
    “…Studying the current medicine use practices and factors affecting the prescribing of an antibiotic would help decision makers to draft policies that would enable a more rational use of medicines. METHODS: A prospective, descriptive, and cross-sectional study was conducted to assess the current prescribing practices including antibiotics use in six community pharmacies in Asmara. …”
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    Prescribing practices using WHO prescribing indicators and factors associated with antibiotic prescribing in six community pharmacies in Asmara, Eritrea: a cross-sectional study
  2. 30642
    “…The mechanistic basis of paradoxical susceptibility to carbapenems provides an impetus to develop better therapeutic approaches to the increasing threat of carbapenem resistance and highlights how the rational design of novel β-lactam/β-lactamase inhibitors must consider mechanistic bases of resistance. …”
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    1829. The Paradox of KPC Bearing Strains of Klebsiella pneumoniae with the D179Y Substitution: Resistance to Ceftazidine/Avibactam (CZA) and Susceptibility to Meropenem (MEM)
  3. 30643
    “…CONCLUSION: The ability to rationally balance the attenuation of multiple vaccine strains, thereby avoiding antibody-dependent enhancement, is a unique advantage of the Codagenix SAVE platform. …”
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    2764. Generation of a Balanced, Tetravalent Dengue Vaccine Based on Contemporary Strains Using a Computational, Synthetic Biology-Based Platform
  4. 30644
    “…BACKGROUND: CMV reactivation in seropositive, non-immunosuppressed adults with sepsis has been associated with worse clinical outcomes. To inform rational design of interventional trials determining whether CMV prevention improves outcomes, it is critical to identify the independence and strength of the association of CMV reactivation measures with clinically-relevant endpoints. …”
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    2307. Risk factors for Cytomegalovirus (CMV) reactivation and Association with Clinical Outcomes in Critically Ill Adults with Sepsis: A Pooled Analysis of Prospective Studies
  5. 30645
    “…In January 2016, an ASP was initiated at our institution with emphasis on rational use of antibiotics, decrease antibiotic duration and timely de-escalation of all empiric antibiotics, including IV vancomycin using nares PCR for MRSA. …”
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    1076. Antimicrobial Stewardship Program Achieves Marked Decrease in the use of Vancomycin in a Veterans Hospital
  6. 30646
    “…Whereas, the three-gene pyramid harboring Pi2, Pi46 and Pita seems superfluous considering its reduced yield, although it also showed displayed high level of blast resistance. Thus, rational use of R genes rather than stacking more R genes is recommended to control the disease.…”
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    Improvement of rice blast resistance by developing monogenic lines, two-gene pyramids and three-gene pyramid through MAS
  7. 30647
    por He, Lian, Fu, Yanfen, Lidstrom, Mary E.
    Publicado 2019
    “…Our quantitative insights into the methanotrophic carbon and energy metabolism will pave the way for future FBA studies and set the stage for rational design of methanotrophic strains for industrial applications. …”
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    Quantifying Methane and Methanol Metabolism of “Methylotuvimicrobium buryatense” 5GB1C under Substrate Limitation
  8. 30648
    “…The accurate inversion of water quality parameters in sewage with visible-near infrared spectroscopy can improve the effectiveness and rational utilization and management of water resources. …”
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    Quantitative estimation of wastewater quality parameters by hyperspectral band screening using GC, VIP and SPA
  9. 30649
    “…Wethers were offered an Eragrotis and Lucerne hay-based total mixed ration diet above maintenance requirement with forage: concentrate ratio 50:50. …”
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    Effect of Lipid-Encapsulated Acacia Tannin Extract on Feed Intake, Nutrient Digestibility and Methane Emission in Sheep
  10. 30650
    “…Additionally, elacestrant may also serve as an endocrine backbone for rational combinations to combat resistance.…”
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    Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors
  11. 30651
    “…There is an optimum of Ca loading into the silicon oxycarbide glassy network (at a Ca/Si molar ration of 0.05), which provides mesoporosity and reaches maximum SSA, both highly beneficial for the bioactive behavior of the materials. …”
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    Facile Preparative Access to Bioactive Silicon Oxycarbides with Tunable Porosity
  12. 30652
    “…Conclusion: The combination of PAN and ADI-PEG20 is a rational translational therapeutic strategy for treating ASS1-low PDAC tumors through synergistic induction of DNA damage.…”
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    Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
  13. 30653
    “…Using model 1, the risk for an individual patient having ALND could be determined, which would lead to a rational therapeutic choice.…”
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    Nomograms for predicting the likelihood of non-sentinel lymph node metastases in breast cancer patients with a positive sentinel node biopsy
  14. 30654
    “…Dengue is the most prevalent arboviral disease afflicting humans, and a vaccine appears to be the most rational means of control. Dengue vaccine development is in a critical phase, with the first vaccine licensed in some countries where dengue is endemic but demonstrating insufficient efficacy in immunologically naive populations. …”
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    Cell-Mediated Immunity Generated in Response to a Purified Inactivated Vaccine for Dengue Virus Type 1
  15. 30655
    “…Crossbred, phenotypically similar beef heifers (n = 32; BW = 385 ± 43 kg) were fed a standard finishing ration without (CON) or with a combination of a live yeast (1.5 g/hd/d) and yeast cell wall product (2.5 g/hd/d; YEAST; Phileo Lesaffre Animal Care, Milwaukee, WI). …”
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    Some Negative Effects of Heat Stress in Feedlot Heifers May Be Mitigated via Yeast Probiotic Supplementation
  16. 30656
    “…However, despite the pathophysiological rational that hypothyroidism can lead to increased rate of CKD progression, we failed to demonstrate an association between LFT and rate of CKD progression. …”
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    Influence of low free thyroxine on progression of chronic kidney disease
  17. 30657
    “…We found a high level of cross-regulation between the two major resistance modules in response to bacitracin stress and quantified their effects on bacterial resistance. To rationalize our experimental data, we expanded a previously established computational model for the lipid II cycle through incorporating the quantitative action of the resistance modules. …”
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    From Modules to Networks: a Systems-Level Analysis of the Bacitracin Stress Response in Bacillus subtilis
  18. 30658
    “…Our findings show that allocation of mature chicory herbage to dairy cows at 50% of their ration modified rumen fermentation and improved both milk yield and the FA profile of the milk. …”
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    Rumen Fermentation and Fatty Acid Composition of Milk of Mid Lactating Dairy Cows Grazing Chicory and Ryegrass
  19. 30659
    “…The incidence of invasive fungal infections (IFIs) has recently increased, and early and accurate diagnosis of IFIs is important for the rational selection of antifungal drugs with high efficacy. …”
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    Rapid identification of clinical common invasive fungi via a multi-channel real-time fluorescent polymerase chain reaction melting curve analysis
  20. 30660
    “…Our data demonstrate that the lack of cross-reactivity in glycan hole antibodies is due to amino acid differences within the epitope, and our attempts to rationally design cross-reactive trimers resulted in only limited success. …”
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    Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits
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