“…The finding of tumor-infiltrating monocytes and differentiating moDCs as druggable target for rational combination therapy opens new avenues of anti-tumor therapy design.…”
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“…This study provides insights into the contribution of mechanisms of respiratory energy coupling in the yeast cell factory Ogataea parapolymorpha under different growth conditions and provides a basis for rational improvement of energy coupling in yeast cell factories. …”
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“…Formal representation of the adverse drug reaction (ADR) enclosed in semistructured package inserts will enable deep recognition of side effects and rational drug use, substantially reduce morbidity, and decrease societal costs. …”
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“…METHODS: Most of the existing computational prediction methods are essentially based on the assumption that similar drugs are inclined to share the same side-effects, which has given rise to remarkable performance. It is also rational to assume an inverse proposition that dissimilar drugs are less likely to share the same side-effects. …”
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“…The burden of depressive symptoms should be reduced through multi-factorial interventions and rational perspectives.…”
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“…Coexistence of numerous resistance genes on a single plasmid may contribute to the dissemination of these genes under pressure posed by different agents, which may explain the presence of clinically crucial resistance genes tet(X) and bla(OXA-58) in livestock. Thus, rational drug use and continued surveillance of tet(X) and bla(OXA-58) in livestock are warranted.…”
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“…Using a simulation approach based on farm data, the objective of the present paper was to describe and evaluate a decision support system for the PF of gestating sows allowing the daily distribution of a tailored ration to each sow. Two datasets, 1 of 2,511 gestations (farm A) and 1 of 2,528 gestations (farm B), reporting sows’ characteristics at insemination and objectives at farrowing were used as inputs for a Python model. …”
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“…BACKGROUND: The majority of South Africans rely on a resource-constrained public healthcare sector, where access to renal replacement therapy (RRT) is strictly rationed. The incidence of RRT in this sector is only 4.4 per million population (pmp), whereas it is 139 pmp in the private sector, which serves mainly the 16% of South Africans who have medical insurance. …”
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“…Management decision inputs had 3 main factors: housing type, ration composition, and labor utilization. Housing systems were calculated separately for confinement, dry-lot, and pasture scenarios. …”
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“…These findings are useful for the rational utilization of carbohydrases in the swine industry. …”
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“…The animals were kept in proper welfare conditions, fed using the partly mixed ration (PMR) method on the feeding table. The milk was obtained using the Lely-Astronaut A4 Automatic Milking System (AMS). …”
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“…The first factor was four rations of R:C at 80:20, 60:40, 40:60, and 20:80, and the second factor was an additional four doses of Saccharomyces cerevisiae (live yeast; LY) at 0, 2.0 × 10(6), 4.0 × 10(6), and 6.0 × 10(6) colony-forming unit (cfu), respectively. …”
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“…Consequently, cocktail optimization has successfully led to an increase in the expansion platform performance, while allowing a rational side-by-side comparison among different platforms and enhancing our knowledge on the impact of cytokine supplementation on the HSPC expansion process.…”
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“…With no safety standards or guidelines for best production practices, the few manufacturing workshops that exist within Bangladesh operate inefficiently and without clear rationalization of manufacturing processes. Haphazard copying of prototypes or imported available machinery is common. …”
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“…The bacterial isolates showed high level of resistance against the antibiotics started as the empiric therapy. Rational use of antibiotics can decrease the adverse outcomes in neonatal sepsis patients.…”
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“…Importantly, we found a significant reduction in expression of BIRC7/Livin and reactivation of DARC and PD-L1 with a surge in Annexin V expression in rat models of CRC cells post-treatment with a sequential dose of aspirin plus FOLFOX compared with other treatments in vivo (p <0.05). The mechanistic rational of these effects underscores the importance of expanded concept of possible aspirin combination therapy with FOLFOX sequentially in future CRC management. …”
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“…A tumor-targeted replicating vaccinia virus Tian Tan strain with deletion of TK gene (TTVΔTK) was armed rationally with IL-21 to create rTTVΔTK-IL21 through recombination. …”
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“…Beginning on days 37 to 42, total mixed ration, refusals, and fecal samples were collected once daily to determine apparent total tract digestibility of DM, CP, NDF, and ADF using indigestible NDF as an internal marker. …”
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“…Important aspects are rationing (time/beds) and incentives for overdiagnosis as well as lack of internal communication culture and mentoring. …”
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“…The provision of appropriate health education was recommended for promoting rational medication use.…”
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