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  1. 30701
    “…Overall, these results may contribute to the identification of novel circulating biomarkers for rational immunotherapy approaches in patients affected by NSCLC.…”
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    Phenotypic and Proteomic Analysis Identifies Hallmarks of Blood Circulating Extracellular Vesicles in NSCLC Responders to Immune Checkpoint Inhibitors
  2. 30702
    “…This study investigated the impact adding whole ground oat as a prebiotic, alone or in combination with a probiotic, yeast culture (YC) (Saccharomyces cerevisiae), to sow gestation and lactation rations had on milk protein composition, piglet growth, and incidence of post-weaning diarrhea (PWD). …”
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    Inclusion of Oat and Yeast Culture in Sow Gestational and Lactational Diets Alters Immune and Antimicrobial Associated Proteins in Milk
  3. 30703
    “…Using principal component regression analysis, we observed that ruminal pH and the acetate:propionate ratio for cows receiving the early lactation ration were positively correlated with milk B12. Bedding did not influence milk B12 in bulk tanks, which averaged 4276 pg/mL. …”
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    Refining Knowledge of Factors Affecting Vitamin B(12) Concentration in Bovine Milk
  4. 30704
    “…Understanding the mechanisms of efficacious oncolytic virotherapy will inform the rational design of improved oncolytic virotherapies.…”
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    Novel Oncolytic Herpes Simplex Virus 1 VC2 Promotes Long-Lasting, Systemic Anti-melanoma Tumor Immune Responses and Increased Survival in an Immunocompetent B16F10-Derived Mouse Melanoma Model
  5. 30705
    “…Herein, we build on the emerging paradigm of rational epitope-based vaccine design, by describing an immunoinformatics tool (Predivac-3.0) for proteome-wide T-cell epitope discovery that accounts for ethnic-level variations in immune responsiveness. …”
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    A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach
  6. 30706
    “…Anthracyclines like daunorubicin and doxorubicin are widely used to treat leukemia in children and adults. A rational combination of protein kinase CK2 inhibitors with the standard of care chemotherapy may help treat AML more effectively. …”
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    Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia
  7. 30707
    “…Our findings warrant rational longan arillus consumption as a dietary supplement or herbal medicine.…”
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    Excessive Intake of Longan Arillus Alters gut Homeostasis and Aggravates Colitis in Mice
  8. 30708
    “…In summary, artificial intelligence and deep learning advancements provide an excellent opportunity for rational drug design and discovery process, which will eventually impact mankind. …”
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    Artificial intelligence to deep learning: machine intelligence approach for drug discovery
  9. 30709
    “…Our findings may help exercise physiologist better understand the impact of hip and knee angles on designing more rational NMES stimulation strategies. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier NCT03822221.…”
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    The Effect of Quadriceps Muscle Length on Maximum Neuromuscular Electrical Stimulation Evoked Contraction, Muscle Architecture, and Tendon-Aponeurosis Stiffness
  10. 30710
    “…This updating review provides the recent knowledge on the use of date palm by-products and improving their utilization in poultry rations. This article focuses on the chemical composition, amino and fatty acids, mineral content, growth performance, economic aspects and nutritional potential in comparison with widely used corn and barley grains in poultry. …”
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    Date (Phoenix dactylifera L.) by-Products: Chemical Composition, Nutritive Value and Applications in Poultry Nutrition, an Updating Review
  11. 30711
    “…Therefore, this paper aims to: rationalize why and how adjuvant, slacklining therapeutic exercise may positively affect patients with NSLBP, due to MF-AMI induced depletion of spinal stabilization; considers current understandings and interventions for NSLBP, including the contributing role of MF-AMI; and details the reasons why slacklining could be considered as a potential adjuvant intervention for NSLBP through its indirect-involuntary action. …”
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    Slacklining as therapy to address non-specific low back pain in the presence of multifidus arthrogenic muscle inhibition
  12. 30712
    “…Elucidation of the mechanism by which N(pro) antagonizes the apoptotic response will help inform the development of rationally designed live-attenuated vaccines and antivirals for control of outbreaks in typically CSFV-free countries.…”
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    Classical Swine Fever Virus N(pro) Antagonizes IRF3 To Prevent Interferon-Independent TLR3- and RIG-I-Mediated Apoptosis
  13. 30713
    “…Collectively, results of the current provide a clearer understanding of the molecular mechanism of the pharmacological effects of G. elegans, which is of great significance for a safer and more rational application of this phytogenic feed additives. …”
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    Integration of Metabolomics and Transcriptomicsto Comprehensively Evaluate the Metabolic Effects of Gelsemium elegans on Pigs
  14. 30714
    “…This study provides a rational recommendation for the appropriate dietary nutrient levels and provides a scientific basis for establishing nutritional standards of yellow-feathered broilers. …”
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    Optimal Level of Supplemental Manganese for Yellow-Feathered Broilers during the Growth Phase
  15. 30715
    por Acuff, Heather L, Aldrich, Charles G
    Publicado 2021
    “…Extruded diets containing graded levels of B. coagulans applied either to the base ration before extrusion or to the exterior of the kibble as a topical coating after extrusion were randomly assigned to 10 individually housed adult beagle dogs (7 castrated males and 3 spayed females) of similar age (5.75 ± 0.23 yr) and body weight (12.3 ± 1.5 kg). …”
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    Evaluation of graded levels of Bacillus coagulans GBI-30, 6086 on apparent nutrient digestibility, stool quality, and intestinal health indicators in healthy adult dogs
  16. 30716
    “…Many antipsychotics are initiated or prescribed in general practice, and a concerningly large subgroup without documented diagnoses relevant for antipsychotics continued to receive them. Rational prescribing, adequate side effect monitoring and further research into reasons for the observed antipsychotic use patterns and their risk–benefit ratio are needed.…”
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    Use of antipsychotics in Denmark 1997–2018: a nation-wide drug utilisation study with focus on off-label use and associated diagnoses
  17. 30717
    “…The cows were fed a total mixed ration composed of sorghum silage (385 g/kg of dry matter (DM)), concentrated mix (175 g/kg DM), and forage cactus (440 g/kg DM). …”
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    Miúda (Nopalea cochenillifera (L.) Salm-Dyck)—The Best Forage Cactus Genotype for Feeding Lactating Dairy Cows in Semiarid Regions
  18. 30718
    por Parisi, Emmanuele, Centore, Roberto
    Publicado 2021
    “…The analysis of the X-ray mol­ecular structures of the two com­plexes allows the deduction of possible rules for a rational design of mixed-tautomer com­plexes.…”
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    Stabilization of an elusive tautomer by metal coordination
  19. 30719
    “…Moreover, the individuation of key genes could contribute to a better understanding of the pathways involved in the pathogenesis, giving the basis for rational therapeutic approaches.…”
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    PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19
  20. 30720
    “…Accomplishing this goal would facilitate the rational design of therapeutic strategies matched to the characteristics of patients and their tumors. …”
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    A Systems Approach to Brain Tumor Treatment
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