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  1. 30841
    “…Understanding immunosuppressive mechanisms specific to prostate TMEs will enable rational immunotherapy strategies to generate effective antitumor immune responses. …”
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    Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor)
  2. 30842
    “…Differential gene expression analysis and scale-up of YLE155, illustrated the potential of the evolved strains to serve as suitable “chassis” for rational engineering approaches towards both increased lipid accumulation, and production of high-added value compounds, through efficient utilization of crude glycerol. …”
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    Novel evolved Yarrowia lipolytica strains for enhanced growth and lipid content under high concentrations of crude glycerol
  3. 30843
    “…Central obesity was defined as waist: height ration of ≥ 0.5. Data was analysed using STATA version 17. …”
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    Association between obesity and cervical intraepithelial neoplasia: results from a case control study in south western Uganda
  4. 30844
    “…Many metabolic pathways, regulatory and transport principles are known, but purely rational approaches often provide only limited progress in production optimization. …”
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    Discovery of novel amino acid production traits by evolution of synthetic co-cultures
  5. 30845
    “…Reasoning that lipogenesis-mediated alterations in membrane lipid poly-unsaturation lie at the basis of therapy resistance, we targeted fatty acid synthase (FASN) as key player in this pathway to evoke an exquisite vulnerability to clinical inducers of reactive oxygen species (ROS), thereby rationalizing a novel clinically actionable combination therapy to overcome therapy resistance. …”
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    Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy
  6. 30846
    “…In addition, concerted efforts are needed to increase patients’ rational healthcare utilization and strengthen current medical security for people with high SES to reduce economic disparities in CHE. …”
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    Associations among socioeconomic status, multimorbidity of non-communicable diseases, and the risk of household catastrophic health expenditure in China: a population-based cohort study
  7. 30847
    “…As the main channel of information dissemination in the context of the epidemic, social media influences public trust and acceptance of the vaccine. The rational application of health behavior theory is a guarantee of effective public health information dissemination. …”
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    COVID-19 Vaccine–Related Information on the WeChat Public Platform: Topic Modeling and Content Analysis
  8. 30848
    “…Our results present the epigenetic changes in HCC that offer the rational selection of epigenetic-driven gene targets for therapeutic intervention or disease prognostication in HCC. …”
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    A genomic enhancer signature associates with hepatocellular carcinoma prognosis
  9. 30849
    “…Two additional values (Efficient Use of Resources and Logic/Rationality) were also discussed and were reasons for some participants voting against some recommendations. …”
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    Public values and guiding principles for implementing epitope compatibility in kidney transplantation allocation criteria: results from a Canadian online public deliberation
  10. 30850
    “…In summary, we delineated epilepsy and developmental trajectories in STXBP1-related disorders using standardized measures, providing a foundation to interpret future therapeutic strategies and inform rational trial design.…”
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    Delineating clinical and developmental outcomes in STXBP1-related disorders
  11. 30851
    “…Care workers completed questionnaires assessing the administrative tasks and burden, staffing and resource adequacy, leadership ability, implicit rationing of nursing care and care worker characteristics and outcomes. …”
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    Administrative burden in Swiss nursing homes and its association with care workers’ outcomes—a multicenter cross-sectional study
  12. 30852
    “…However, it was expensive and time-consuming for the achievable rational modification to strengthen stress tolerance robustness of aldehyde inhibitors. …”
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    Cold plasma pretreatment reinforces the lignocellulose-derived aldehyde inhibitors tolerance and bioethanol fermentability for Zymomonas mobilis
  13. 30853
    “…Of the 16 aspects evaluated with regards to the medical staff’s self-perception of the internet hospital services, the highest scores were given for fee transparency, fee rationality, travel cost capital, patience and responsibility, and consultation behaviors. …”
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    The construction and operational models of internet hospitals in China: a hospital-based survey study
  14. 30854
    “…These models utilized contextually relevant adaptations for staff and facility competencies and organizational and facilitative administration, which had considerable scope for improvement in terms of recruitment, competency development, programmatic implementation support, and rationalizing the joint needs of the program and implementers. …”
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    Implementation of PM-JAY in India: a qualitative study exploring the role of competency, organizational and leadership drivers shaping early roll-out of publicly funded health insurance in three Indian states
  15. 30855
    “…PURPOSE: Surface-guided radiotherapy (SGRT) has been demonstrated to be a promising supplement to cone-beam computed tomography (CBCT) in adjuvant breast cancer radiotherapy, but a rational combination mode is lacking in clinical practice. …”
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    Optimal fractionation and timing of weekly cone-beam CT in daily surface-guided radiotherapy for breast cancer
  16. 30856
    “…It is necessary to promote the rational use of health services by diabetic patients and further improve the corresponding policies to achieve the goal of chronic disease prevention and control in “Health China 2030”.…”
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    Exploring the factors influencing the use of health services by people with diabetes in Northwest China: an example from Gansu Province
  17. 30857
    “…The workload-based DEA model gives a relatively rational judge on the increase of income brought by scale expansion, and evaluates some special departments like Critical Care Medicine Dept., Geriatrics Dept. and Rehabilitation Medicine Dept. more properly, which better adapts to the functional orientation of public hospitals in China. …”
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    Assessing resource allocation based on workload: a data envelopment analysis study on clinical departments in a class a tertiary public hospital in China
  18. 30858
    “…PURPOSE: To introduce a biomarker-based dosimetry method for the rational selection of a treatment activity for patients undergoing radioactive iodine (131)I therapy (RAI) for metastatic differentiated thyroid cancer (mDTC) based on single-timepoint imaging of individual lesion uptake by (124)I PET. …”
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    The use of single-timepoint images to link administered radioiodine activity (MBq) to a prescribed lesion radiation-absorbed dose (cGy): a regression-based prediction interval tool for the management of well-differentiated thyroid cancer patients
  19. 30859
    “…In individuals with multiple comorbidities, the simultaneous use of multiple medications, also known as polypharmacy, is common, and rational use of medications is essential. This study aims to describe the pharmacotherapeutic profile, estimate the prevalence of polypharmacy and identify factors associated with polypharmacy in a cohort of adult PWH from a referral unit in Rio de Janeiro, Brazil. …”
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    Pharmacotherapeutic profile, polypharmacy and its associated factors in a cohort of people living with HIV in Brazil
  20. 30860
    “…Therefore, proper hygienic practices throughout the milk chain as well as rational drug use are advised.…”
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    Occurrence and antimicrobial susceptibility patterns of Escherichia coli and Escherichia coli O157 isolated from cow milk and milk products, Ethiopia
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