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  1. 30861
    “…CONCLUSIONS: Our findings indicate that telehealth for PrEP delivery can enhance service rationalization and reinforce the prevention cascade. …”
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    Telehealth effectiveness for pre‐exposure prophylaxis delivery in Brazilian public services: the Combine! Study
  2. 30862
    “…Delayed antibiotic prescription (DAP) is designed to deploy a more rational use of antibiotics. While studies have evaluated DAP efficacy and safety for children with RTIs, little research has been conducted on the economic implications. …”
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    A trial-based cost-effectiveness analysis of antibiotic prescription strategies for non-complicated respiratory tract infections in children
  3. 30863
    “…Notably, the SGLT-2i group exhibited a higher angina symptom control rate than the non-SGLT-2i group (adjusted odd ration (OR) 0.45, 95%CI 0.21–0.93, P = 0.031). CONCLUSION: In recently diagnosed patients with ACS, who have T2DM, early initiation of SGLT-2i was associated with a lower risk of rehospitalization for HF and a higher rate of angina symptom control. …”
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    Cardiovascular protective effect of sodium-glucose cotransporter 2 inhibitors on patients with acute coronary syndrome and type 2 diabetes mellitus: a retrospective study
  4. 30864
    Publicado 2023
    “…The health institutions concerned should dedicate more attention to the vulnerable populations who have difficulty accessing health services, focus on the commonly shared influencing factors of health service utilization among urban and rural residents, take into account the differences, rationally allocate health resources, and improve the effective utilization rate of health services among residents in Tibet.…”
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    西藏地区城乡居民卫生服务利用影响因素对比分析
  5. 30865
    “…Interviews highlighted that a sense of duty motivated people to adhere to isolation guidance and where people did leave their homes, these decisions were based on rational calculations of the risk of transmission – people would only leave their homes when they thought they were unlikely to come into contact with others. …”
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    Understanding adherence to self-isolation in the first phase of the COVID-19 pandemic in England: a cross-sectional mixed-methods study
  6. 30866
    “…Support during the pandemic was reported to be low, with less than 50% of HHs reporting relief meeting their needs; only 36% and 15% of these HHs received rations in camps and host communities respectively. …”
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    Livelihood challenges of single female household heads in the Rohingya and host communities in Cox’s Bazar, Bangladesh during the COVID-19 pandemic
  7. 30867
    “…This study identified determinants of unplanned extubating among patients admitted to the pediatric intensive care unit: agitated patients (AOR = 3.708; 99% CI: 1.401–9.81), working in night shift hours (AOR: 8.789; 99% CI: 2.37–32.58), use of plaster or roll bandages separately (AOR = 4.12; 99% CI: 1.215–13.96), A nurse-to-patient ration 1:2 (AOR: 6.65, 99% CI: 1.87–23.69), intermittent sedation (AOR, 3.717; 99% CI, 1.017–10.816), physically restrained (AOR = 3.717; 99% CI: 1.02–13.54), and death outcome (AOR = 14.86, 99% CI: 3. 24–68.097), respectively. …”
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    Incidence, Outcome and Determinants of Unplanned Extubation Among Pediatric Intensive Care Unit Addis Ababa, Ethiopia, 2023: Nested, Unmatched Case-Control Study Design
  8. 30868
    “…It was found that DDIT4 has rational accuracy and high sensitivity as a diagnostic marker. …”
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    Nuclear overexpression of DNA damage-inducible transcript 4 (DDIT4) is associated with aggressive tumor behavior in patients with pancreatic tumors
  9. 30869
    “…The immune-regulatory responses activated by ATRA suggest that the retinoid and immune-checkpoint inhibitors constitute rational combinations for the management of gastric-cancer. …”
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    Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
  10. 30870
    “…Probiogenomics, involving high-throughput techniques, can help identify uncharacterized strains and aid in the rational selection of new probiotics. This study evaluates the potential of the Escherichia coli CEC15 strain as a probiotic through in silico, in vitro, and in vivo analyses, comparing it to the well-known probiotic reference E. coli Nissle 1917. …”
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    Comprehensive probiogenomics analysis of the commensal Escherichia coli CEC15 as a potential probiotic strain
  11. 30871
    “…These findings could help healthcare policy makers to optimize the distribution of resources and professionals within PC and HC systems, aiming for the improvement of polypharmacy management and rational use of medicines while reducing costs attributed to healthcare utilization by these patients. …”
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    Differences in healthcare service utilization in patients with polypharmacy according to their risk level by adjusted morbidity groups: a population-based cross-sectional study
  12. 30872
    “…As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cancer (SCLC) cell populations during protracted VP-16 exposure. …”
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    Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.
  13. 30873
    “…This has raised serious questions about rationing when there are insufficient beds for all those referred. …”
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    Implications of ICU triage decisions on patient mortality: a cost-effectiveness analysis
  14. 30874
    por Eccles, Suzanne A, Aboagye, Eric O, Ali, Simak, Anderson, Annie S, Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P, Brennan, Keith, Brown, Nicola J, Bryant, Helen E, Bundred, Nigel J, Burchell, Joy M, Campbell, Anna M, Carroll, Jason S, Clarke, Robert B, Coles, Charlotte E, Cook, Gary JR, Cox, Angela, Curtin, Nicola J, Dekker, Lodewijk V, dos Santos Silva, Isabel, Duffy, Stephen W, Easton, Douglas F, Eccles, Diana M, Edwards, Dylan R, Edwards, Joanne, Evans, D Gareth, Fenlon, Deborah F, Flanagan, James M, Foster, Claire, Gallagher, William M, Garcia-Closas, Montserrat, Gee, Julia M W, Gescher, Andy J, Goh, Vicky, Groves, Ashley M, Harvey, Amanda J, Harvie, Michelle, Hennessy, Bryan T, Hiscox, Stephen, Holen, Ingunn, Howell, Sacha J, Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S, Jasani, Bharat, Jones, Louise J, Key, Timothy J, Kirwan, Cliona C, Kong, Anthony, Kunkler, Ian H, Langdon, Simon P, Leach, Martin O, Mann, David J, Marshall, John F, Martin, Lesley Ann, Martin, Stewart G, Macdougall, Jennifer E, Miles, David W, Miller, William R, Morris, Joanna R, Moss, Sue M, Mullan, Paul, Natrajan, Rachel, O’Connor, James PB, O’Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul D P, Rakha, Emad A, Reed, Elizabeth, Robinson, Simon P, Sahai, Erik, Saxton, John M, Schmid, Peter, Smalley, Matthew J, Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H, Tutt, Andrew N J, Velikova, Galina, Walker, Rosemary A, Watson, Christine J, Williams, Kaye J, Young, Leonie S, Thompson, Alastair M
    Publicado 2013
    “…RESULTS: The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. …”
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    Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
  15. 30875
    “…If the efficacy of PTX3003 is confirmed, rational polytherapy based on novel combinations of existing non-toxic drugs with pleiotropic effects may represent a promising approach for rapid drug development. …”
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    Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy
  16. 30876
    “…DISCUSSION: SWITCH is a well-designed trial in this therapeutic area that aims to develop a rational treatment algorithm to potentially inform personalised treatment regimens (as opposed to switching all patients to only one available (and possibly unsuccessful) therapy), which may lead to long-term improved patient outcomes and gains in population health. …”
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    The 'Switch’ study protocol: a randomised-controlled trial of switching to an alternative tumour-necrosis factor (TNF)-inhibitor drug or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-inhibitor drug
  17. 30877
    “…This in vitro and in vivo study corroborates a potential novel mechanism by which UA controls HCC growth and implies that the rational targeting IGFBP1 and FOXO3a can be potential for the therapeutic strategy against HCC.…”
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    Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
  18. 30878
    “…CONCLUSION: The overlap of multi-drug resistant bacteria and diversity of the genotypes carrying CTX-M-15 in the community and hospitals requires an overall approach that addresses social behaviour and activity, rationalization of the antibiotic stewardship policy and a deeper understanding of the ecological factors that lead to persistence and spread of such alleles.…”
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    Predictors of bla(CTX-M-15) in varieties of Escherichia coli genotypes from humans in community settings in Mwanza, Tanzania
  19. 30879
    “…BACKGROUND: As malaria control interventions are scaled-up, rational approaches are needed for monitoring impact over time. …”
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    Pregnant women and infants as sentinel populations to monitor prevalence of malaria: results of pilot study in Lake Zone of Tanzania
  20. 30880
    “…A ‘Warning’ response may represent a rational trigger, besides ‘Failure’, for DS-based mutation screening in CML patients undergoing second-line TKI therapy.…”
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    In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants
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