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  1. 30921
    “…Incremental cost effectiveness ration (ICER) was computed. Health Utility Index (HUI-3) was used to measure utility gain, a component required to derive the quality adjusted life years (QALY). …”
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    Cost-utility analysis of hearing aid device for older adults in the community: a delayed start study
  2. 30922
    “…Identified compounds may provide a starting point in the rational design of PTKT inhibitors and analogues based on these scaffolds.…”
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    Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
  3. 30923
    “…Understanding was measured primarily through qualitative pretesting, rationality or validity tests included in the survey, and participant self-report, however reporting and use of the results of these methods was inconsistent. …”
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    Respondent Understanding in Discrete Choice Experiments: A Scoping Review
  4. 30924
    “…The intervention aimed to increase provision of core OA treatment (information, exercise, and weight control) prior to referral for surgery, rational use of imaging for assessing OA and improve communication between healthcare professionals. …”
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    Improving osteoarthritis management in primary healthcare: results from a quasi-experimental study
  5. 30925
    “…The study found that male gender (2.98; adjusted odds ration [AOR] = 2.98; 95% CI; 1.49–5.95), no ability to read and write (3.99; AOR = 3.99; 95% CI: 1.53–10.4), history of hospitalization (3.95; AOR = 3.95; 95% CI: 1.87–8.32), perceived internal stigma (2.45, AOR = 2.45; 95% CI: 1.18–5.11), and poor social support (3.07, AOR = 3.07; 95% CI: 1.29–7.30) were significant predictors of risky sexual behaviors among patients with severe mental disorder. …”
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    Risky sexual behavior and its associated factors among patients with severe mental disorder in University of Gondar Comprehensive Specialized Hospital, 2018
  6. 30926
    “…As a DST-guided precision treatment, TB-TRUST are expected to optimize therapy outcome in more patients who cannot afford the expensive new medicines and minimize and even avoid resistance amplification with the rational use of anti-TB drugs. TRAIL REGISTRATION: ClinicalTrial.gov, NCT03867136. …”
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    Refining MDR-TB treatment regimens for ultra short therapy (TB-TRUST): study protocol for a randomized controlled trial
  7. 30927
    “…The study also revealed that proper IEC/BCC drives help increase community acceptance of vector control measures and their rational usage.…”
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    Improvement of Indoor Residual Spraying and Long‐Lasting Insecticidal Net services through structured monitoring and supervision as part of the Malaria Elimination Demonstration Project in Mandla, Madhya Pradesh
  8. 30928
    “…CONCLUSIONS: This study demonstrated that combinatorial strategies rationally designed on biological effects can turn immunotherapy-resistant tumors into immunologically responsive tumors. …”
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    Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy
  9. 30929
    “…Future studies are needed to evaluate whether IMS, combined with malaria diagnostics, may be used to rationalize antimicrobial prescription in malaria endemic areas. …”
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    Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso
  10. 30930
    “…The immediate adaptation strategies of the farmers were engaging family labors, exchanging labors with neighbouring farmers, borrowing money from relatives, accessing free food rations, replacing dead livestock, early harvesting, and reclamation of waterbodies. …”
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    Multi-faceted impact and outcome of COVID-19 on smallholder agricultural systems: Integrating qualitative research and fuzzy cognitive mapping to explore resilient strategies
  11. 30931
    “…METHODS: The guideline development process consisted of three steps: (1) rapid review of existing rationing guidelines and literature; (2) interviews of Thai clinicians experienced in caring for COVID-19 cases; and (3) multi-stakeholder consultations. …”
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    Developing a Thai national critical care allocation guideline during the COVID-19 pandemic: a rapid review and stakeholder consultation
  12. 30932
    “…In order to take informed decisions in a fully rational manner, the onset of a critical regime, characterized by an exponential growth of the contagion, must be identified as quickly as possible. …”
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    Decision support for the quickest detection of critical COVID-19 phases
  13. 30933
    “…Several mechanisms, including lung recruitment and better lung ventilation/perfusion matching, make a relevant rational for using PP. However, not all patients maintain the oxygenation improvement after returning to supine position. …”
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    Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study
  14. 30934
    “…The bioprocess development for scalable and reliable whole cell biocatalyst production in bioreactors was carried out based on rational optimization criteria. Among the different alternatives studied, a glycerol carbon-limiting strategy at high µ showed highest production rates, while methanol co-addition together with a decrease of µ provided the best results in terms of product to biomass yield and whole cell activity. …”
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    Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9
  15. 30935
    “…BACKGROUND: Regular monitoring of anti-malarial drug efficacy is vital for establishing rational malaria treatment guidelines and ensuring adequate treatment outcomes. …”
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    Efficacy and safety of artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia: a systematic review and meta-analysis
  16. 30936
    “…As exemplified here for glutarate production by C. glutamicum, this approach allowed deducing rational metabolic engineering strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12934-021-01586-3.…”
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    Adaptive laboratory evolution accelerated glutarate production by Corynebacterium glutamicum
  17. 30937
    “…We then outline current ethical decision procedures and recommendations for rationing life-sustaining treatment during the COVID-19 pandemic, and examine the extent to which current guidelines for ECMO allocation (and reported practice) adhere to these ethical guidelines and recommendations. …”
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    Ethical factors determining ECMO allocation during the COVID-19 pandemic
  18. 30938
    “…Healthcare students are the future health professionals who will be consistently responsible for educating the public on rational use of medication. This study therefore aimed to assess the prevalence, knowledge and perception of self-medication practices among healthcare students. …”
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    Prevalence, knowledge and perception of self-medication practice among undergraduate healthcare students
  19. 30939
    “…RESULTS: Drivers for implementation were making ‘better’ decisions, achieving transparency and a rational selection process, reducing drug shortages, and assuring consistent quality. …”
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    Case studies for implementing MCDA for tender and purchasing decisions in hospitals in Indonesia and Thailand
  20. 30940
    “…BACKGROUND: With inappropriate use of antimicrobials becoming a great public health concern globally, the issue of applying clinical practice guidelines (CPGs) to regulate the rational use of antimicrobials has attracted increasing attention. …”
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    Predictors of physicians’ intentions to use clinical practice guidelines on antimicrobial in tertiary general hospitals of China: a structural equation modeling approach
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