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  1. 30941
    “…These data also suggest that PIM inhibitors may be a rational therapeutic option for LKB1-deficient tumors. …”
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    PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
  2. 30942
    “…School-wide preventative interventions (e.g., positive behavioural strategies- Rational Emotive Behavioral Education, [REBE], peer educator network systems, face-face counseling sessions, substance use cessation therapy) are essential in promoting a positive school climate and reduce students’ bullying victimisation behaviours. …”
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    A multi-country analysis of the prevalence and factors associated with bullying victimisation among in-school adolescents in sub-Saharan Africa: evidence from the global school-based health survey
  3. 30943
    “…The capacity of two heterologous antivenoms to immunocapture the H. curtus venom was determined for an in-depth evaluation of their rationality in treatment of H. curtus envenomation. …”
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    Venom-gland transcriptomic, venomic, and antivenomic profiles of the spine-bellied sea snake (Hydrophis curtus) from the South China Sea
  4. 30944
    “…BACKGROUND: Internationally, health and social services are undergoing creative and extensive redesign to meet population demands with rationed budgets. This has critical implications for the health workforces that serve such populations. …”
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    Co-designing a methodology for workforce development during the personalisation of allied health service funding for people with disability in Australia
  5. 30945
    “…Altogether, the work broadens our views on genomic integration and the rational use of different integrative loci versus replicative plasmids, when aiming at expressing heterologous genes in Synechocystis. …”
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    Comparison of alternative integration sites in the chromosome and the native plasmids of the cyanobacterium Synechocystis sp. PCC 6803 in respect to expression efficiency and copy number
  6. 30946
    “…CLINICAL SIGNIFICANCE: There is important need to understand differences in the mental cognitive ability of the children at different ages and the need to develop different intervention programs for different age-groups. Rationalizing reading can be an intelligent initiative toward the development of good oral habits and transforming the outlook of oral healthcare system in years to come. …”
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    Comparison between Conventional, Game-based, and Self-made Storybook-based Oral Health Education on Children's Oral Hygiene Status: A Prospective Cohort Study
  7. 30947
    “…While medications were actively prescribed for the 3 conditions, the study found variations by medication type, age, gender and nationality. Rational guidelines for the utilisation of medications need to be established with the support of real-world evidence. …”
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    Diabetes, hypertension and dyslipidemia medication prescribing in Qatari primary care settings: a retrospective analysis of electronic medical records
  8. 30948
    “…CONCLUSIONS: The ASAP model is an accurate tool for HCC risk estimation that requires recalibration before use in a new region because calibration varies with clinical environments. Additionally, rational risk stratification and risk-based management decision-making, e.g., 3-month follow-up recommendations for targeted individuals, helped improve HCC surveillance, which warrants assessment in larger cohorts. …”
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    Validation and update of a multivariable prediction model for the identification and management of patients at risk for hepatocellular carcinoma
  9. 30949
    “…Pharmacists in developed countries ensure rational drug use, improve clinical outcomes, and promote health status by working as part of a multidisciplinary team of healthcare professionals. …”
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    The impact of clinical pharmacist services on patient health outcomes in Pakistan: a systematic review
  10. 30950
    “…Variants inspired by the structural diversity in the GH53 family were rationally designed to shorten or extend the substrate binding groove, in order to modulate product length. …”
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    Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans
  11. 30951
    “…Desirable PK and PD properties were observed, and a modeling approach was used for rational dose selection for subsequent trials. Poseltinib was confirmed as a potential BTK inhibitor for the treatment of autoimmune diseases. …”
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    Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection
  12. 30952
    “…We sought to evaluate the current treatment's rationality and provide a reference basis for the gender reassignment in 46, XY DSD patients with a specific diagnosis. …”
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    One hundred twelve cases of 46, XY DSD patients after initial gender assignment: a short-term survey of gender role and gender dysphoria
  13. 30953
    “…In multivariable analysis, male sex (adjusted odds ration (adjOR) = 1.06, 95% CI:1.03-1.09); Asian race (adjOR = 1.08, CI:1.03-1.13); history of chronic kidney disease (adjOR = 1.05, CI:1.01-1.09) and interstitial lung disease (adjOR = 1.35, CI:1.28-1.42); low or normal body mass index (adjOR:1.03, CI:1.00-1.07); higher comorbidity index (adjOR = 1.01, CI:1.01-1.02); admission from a facility (adjOR = 1.14, CI:1.09-1.20); and mechanical ventilation (adjOR = 1.52, CI:1.43-1.62) were associated with mortality. …”
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    Geriatrics-focused indicators predict mortality more than age in older adults hospitalized with COVID-19
  14. 30954
    “…Sri Lanka established a new National Medicines Regulatory Authority in 2015 and this survey evaluated the medication use indicators in Sri Lanka, according to the International Network on Rational Use of Drugs (INRUD), prior to its implementation. …”
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    WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka
  15. 30955
    “…This study represents an important step towards understanding and promoting tools to guide safe and rational reduction of PIM use among older adults. TRIAL REGISTRATION: NCT04762303, Registered February 21, 2021.…”
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    Spread and scale of an electronic deprescribing software to improve health outcomes of older adults living in nursing homes: study protocol for a stepped wedge cluster randomized trial
  16. 30956
    “…The aims of the present study were to provide scientific bases for rational use of crop straw to substitute chemical potassium (K) input. …”
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    Long-term straw returning improve soil K balance and potassium supplying ability under rice and wheat cultivation
  17. 30957
    “…CONCLUSION: Our findings outline a rational approach to therapy optimization with meaningful consequences for how we effectively design treatment schedules (timing) to maximize their success, and how we treat PDAC with combined 5-FU and anti- CD25 therapies. …”
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    Prediction of anti-CD25 and 5-FU treatments efficacy for pancreatic cancer using a mathematical model
  18. 30958
    “…OBJECTIVE: Our organization is planning an awareness-cum-engagement intervention—door-to-door basic eye checkup and visual acuity screening in VCs coverage areas—to connect with the community and improve the rational use of VCs. METHODS: In this randomized, parallel-group experimental study, we will select 2 VCs each for the intervention arm and the control arm from among poor, low-performing VCs (ie, walk-in of ≤10 patients/day) in our 2 operational regions (Vrindavan, Mathura District, and Mohammadi, Kheri District) of Uttar Pradesh. …”
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    Effect of Door-to-Door Screening and Awareness Generation Activities in the Catchment Areas of Vision Centers on Service Use: Protocol for a Randomized Experimental Study
  19. 30959
    “…However, the possibility and rationality for flexible time regimen are pending. OBJECTIVE: We studied the efficacy of biweekly versus weekly PEGylated rhGH (PEG-rhGH) therapy in GHD children. …”
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    Reduced Effectiveness and Comparable Safety in Biweekly vs. Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trial
  20. 30960
    “…Therefore, an integrated approach such as: proper dog handling practices; continuous evaluation of antimicrobial resistance; and rational use of antimicrobials in the field of veterinary sector are necessary to tackle the problem.…”
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    Isolation, antimicrobial susceptibility patterns, and risk factors assessment of non-typhoidal Salmonella from apparently healthy and diarrheic dogs
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